10 Medications For Dog Anxiety - PetMD

5. Dexmedetomidine (Sileo) 

Used in dogs for: situational anxiety, noise phobias, aversions 

Sileo is the first FDA-approved medication to help dogs with fear and anxiety triggered by noise aversion. It’s an alpha-2 adrenoceptor agonist that works by depressing activity in certain parts of the brain, resulting in reduced anxiety levels and relaxation. 

The drug works best when given 30–60 minutes before a triggering noise event or at the earliest sign that a dog is becoming anxious. 

Sileo is dispensed in a multidose tube as a transmucosal gel. The medication shouldn’t be swallowed—instead, it’s absorbed in the mouth tissue when applied between the cheek and gums. Wear waterproof disposable gloves when handling the syringe and administering the medication. 

Potential side effects may include: 

• Drowsiness 

• Vomiting 

• Weakness 

• Loss of balance 

• Sedation 

• Head tremor 

• Inappropriate urination 

6. Diazepam  

Used in dogs for: situational anxiety, panic disorders, noise aversion, phobia 

Whenever possible, diazepam should be given to dogs 30–60 minutes in advance of an event that’s known to cause anxiety. The drug can also be given at the earliest sign that a dog is becoming anxious, but it works best when given before an anxiety inducing event. 

It’s a member of the benzodiazepine class of sedatives, which work by depressing activity in certain parts of the central nervous system. Diazepam is a short-acting medication that takes effect quickly.  

If this medication is ever used long-term, it should not be stopped suddenly. Always work with your vet when weaning your dog off a medication. 

Potential side effects may include: 

• Grogginess 

• Sedation 

• Loss of balance 

• Increased appetite 

• Agitation 

• Aggression