511402: Maternal Cell Contamination - Labcorp

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4. 511402: Maternal Cell Contamination

Maternal Cell Contamination Test Number 511402Test number copied CPT 81265

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• Test Details
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Test Details

Methodology

Analysis of short tandem repeat markers by multiplex fluorescent polymerase chain reaction (PCR) and capillary electrophoresis

Result Turnaround Time

11 - 21 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

• Sample Report

Use

This test is used to rule out the presence of maternal cell contamination within a fetal specimen to aid in the accurate interpretation of prenatal molecular genetic or cytogenetic results.

Special Instructions

Maternal samples sent for maternal cell contamination studies should be submitted under a separate requisition from fetal specimens (CVS or amniotic fluid).

Limitations

False positive or negative results may occur for reasons that include genetic variants, blood transfusions, bone marrow transplantation, or erroneous characterization of family relationships. Molecular-based testing is highly accurate, but as in any laboratory test, rare diagnostic errors may occur. Results are provided for identification of maternal cell contamination in the specimen itself, and not for diagnostic purposes.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Specimen Requirements

Specimen

Whole blood or PurFlock buccal swab kit or Oragene Dx saliva kit

Volume

8.5 mL whole blood or PurFlock buccal swab kit or Oragene Dx 500 saliva collection kit

Minimum Volume

3 mL whole blood or PurFlock buccal swab kit or Oragene Dx saliva kit

Container

Lavender-top (EDTA) tube, pink-top (EDTA) tube, tan-top (EDTA) tube, yellow-top (ACD-A) tube, or PurFlock buccal swab kit or Oragene Dx 500 saliva collection kit

Stability Requirements

Temperature	Period
Room temperature	Whole blood: 14 days; Buccal: 60 days; Saliva: 60 days
Refrigerated	Whole blood: 30 days at 4°C

Storage Instructions

Standard phlebotomy. Follow PurFlock buccal swab kit or Oragene Dx 500 saliva kit collection instructions. Do not eat, drink, smoke or chew gum 30 minutes prior to collection.

Causes for Rejection

Frozen or hemolyzed specimen; quantity not sufficient for analysis; improper container

References

Bacher J, Schumm JM. Development of Highly Polymorphic Pentanucleotide Tandem Repeat Loci with Low Stutter. Promega Corporation Profiles in DNA. 1998;2(2):3-6.Ensenberger M, Thompson J, Hill B, et al. Developmental validation of the PowerPlex 16 HS System: an improved 16-locus fluorescent STR multiplex. Forensic Sci Int Genet. 2010 Jul;4(4):257-264.20457027Nagan N, Faulkner NE, Curtis C, Schrijver I, MCC Guidelines Working Group of the Association for Molecular Pathology Clininical Practice Committee. Laboratory guidelines for detection, interpretation, and reporting of maternal cell contamination in prenatal analyses a report of the association for molecular pathology. J Mol Diagn. 2011 Jan;13(1):7-11.21227389

LOINC® Map

Order Code	Order Code Name	Order Loinc	Result Code	Result Code Name	UofM	Result LOINC
511402	Maternal Cell Contamination	511401	Maternal Cell Contamination	59266-7
511402	Maternal Cell Contamination	511887	Specimen Type	31208-2
511402	Maternal Cell Contamination	511888	Result	41103-3
511402	Maternal Cell Contamination	511889	Director Review	72486-4
511402	Maternal Cell Contamination	512123	PDF	11502-2
Order Code	511402
Order Code Name	Maternal Cell Contamination
Order Loinc
Result Code	511401
Result Code Name	Maternal Cell Contamination
UofM
Result LOINC	59266-7
Order Code	511402
Order Code Name	Maternal Cell Contamination
Order Loinc
Result Code	511887
Result Code Name	Specimen Type
UofM
Result LOINC	31208-2
Order Code	511402
Order Code Name	Maternal Cell Contamination
Order Loinc
Result Code	511888
Result Code Name	Result
UofM
Result LOINC	41103-3
Order Code	511402
Order Code Name	Maternal Cell Contamination
Order Loinc
Result Code	511889
Result Code Name	Director Review
UofM
Result LOINC	72486-4
Order Code	511402
Order Code Name	Maternal Cell Contamination
Order Loinc
Result Code	512123
Result Code Name	PDF
UofM
Result LOINC	11502-2