Actonel (risedronate) Dosing, Indications, Interactions, Adverse ...

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Tools & Referencerisedronate (Rx)Brand and Other Names:Actonel, Atelvia, more...Actonel with Calcium

  • Classes: Calcium Metabolism Modifiers;
  • Bisphosphonate Derivatives
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Sections
  • Sections risedronate
  • Dosing & Uses
  • Interactions
  • Adverse Effects
  • Warnings
  • Pregnancy
  • Pharmacology
  • Administration
  • Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

  • 5mg
  • 30mg
  • 35mg
  • 150mg

tablet, delayed release

  • 35mg

Postmenopausal Osteoporosis

Treatment and prevention

5 mg PO once daily or 35 mg PO once weekly or 150 mg PO once monthly

35 mg once-weekly dosing copackaged with calcium carbonate 1250 mg for remaining 6 days of week

Glucocorticoid-Induced Osteoporosis

5 mg/day PO

Paget Disease

30 mg/day PO for 2 months

Monitor serum alkaline phosphatase

Osteoporosis in Men

35 mg PO once weekly

Osteogenesis Imperfecta (Orphan)

Orphan indication sponsor

  • Warner Chilcott Pharmaceuticals; 100 Enterprise Drive; Rockaway, NJ 07866

Dosing Modifications

Renal impairment

  • CrCl >30 mL/min: No dose adjustment necessary
  • CrCl 10%

    Arthralgia (7-33%)

    Diarrhea (5-20%)

    Headache (3-18%)

    Nausea (4-13%)

    Constipation (3-13%)

    Rash (8-12%)

    Abdominal pain (2-12%)

    Hypertension (11%)

    Dyspepsia (4-11%)

    1-10%

    Flulike syndrome (10%)

    Depression (7%)

    Chest pain (5-7%)

    Dizziness (3-7%)

    Pharyngitis (6%)

    Rhinitis (6%)

    Prostatic hyperplasia (5%)

    Hypocalcemia (

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