C-type Natriuretic Peptide (CNP): Cardiovascular Roles And ... - PubMed

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Abstract

Natriuretic peptides play a fundamental role in cardiovascular homeostasis by modulation of fluid and electrolyte balance and vascular tone. C-type natriuretic peptide (CNP) represents the paracrine element of the natriuretic peptide axis which complements the endocrine actions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). CNP is produced by the endothelium and the heart and appears to play a prominent role in vascular and cardiac function, both physiologically and pathologically. This provides a rationale for the therapeutic potential of pharmacological interventions targeted to CNP signalling. This article provides an overview of the biology and pharmacology of CNP, with emphasis on the cardiovascular system, and discusses pathologies in which drugs designed to manipulate CNP signalling maybe of clinical benefit.

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Figures

Figure 1

Schematic depicting the multi-faceted, anti-atherogenic…

Figure 1

Schematic depicting the multi-faceted, anti-atherogenic profile of endothelium-derived CNP

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References

1. 1. Sudoh T, Minamino N, Kangawa K, Matsuo H. C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun. 1990 Apr 30;168(2):863–70. - PubMed
2. 1. de Bold AJ, Borenstein HB, Veress AT, Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 1981 Jan 5;28(1):89–94. - PubMed
3. 1. Stingo AJ, Clavell AL, Heublein DM, Wei CM, Pittelkow MR, Burnett JC., Jr Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Physiol. 1992 Oct;263(4 Pt 2):H1318–H1321. - PubMed
4. 1. Chen HH, Burnett JC., Jr C-type natriuretic peptide: the endothelial component of the natriuretic peptide system. J Cardiovasc Pharmacol. 1998;32(Suppl 3):S22–S28. - PubMed
5. 1. Kalra PR, Anker SD, Struthers AD, Coats AJ. The role of C-type natriuretic peptide in cardiovascular medicine. Eur Heart J. 2001 Jun;22(12):997–1007. - PubMed

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