Carl Ludwig And The Localization Of The Medullary Vasomotor Center

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Personal name as subject

Title & authors Abstract Publication types MeSH terms Personal name as subject CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

In Carl Ludwig's laboratories in Leipzig, P. Owsjannikow (1871) and C. Dittmar (1873) performed precise, histologically controlled lesioning experiments into the question of the location of the vasomotor center in the medulla oblongata. A small area in the ventrolateral parts of the medulla with its caudal border 3 mm cranial to the obex and an extension of 3-4 mm in cranial direction was described as the vasomotor area which has to be left intact for normal vasomotor tone and reflexes. This finding, ignored for more than 100 years, is the most precise description of what is known today as the location of spinally projecting sympatho-excitatory neurones, named the RVML region. Already in these early publications the question of the origin of basic vasomotor tone within these areas was raised and the possibilities of automaticity and reflexogenic input were discussed. Both possibilities are still valid today and under current investigation. A specific chemosensitivity of the RVLM neurones has been demonstrated during the recent decade and its role with regard to the generation of the sympathetic tone and the nervous control of the entire cardiovascular system is being discussed.

PubMed Disclaimer

Publication types

• Biography Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Historical Article Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• History, 19th Century Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Humans Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Medulla Oblongata / physiology* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Models, Neurological* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Physiology / history Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Sympathetic Nervous System / physiology* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Vasomotor System / physiology Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Personal name as subject

• C Ludwig Actions
  • Search in PubMed
  • Add to Search
• P Owsjannikow Actions
  • Search in PubMed
  • Add to Search
• C Dittmar Actions
  • Search in PubMed
  • Add to Search

[x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.