Combinations - When Should I Take L-tyrosine With Adderall?

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• DRUG INFORMATION & HARM REDUCTION
• Stimulants
• Amphetamine
• Adderall

You are using an out of date browser. It may not display this or other websites correctly.You should upgrade or use an alternative browser. CombinationsWhen should I take L-tyrosine with adderall?

• Thread starter Thread starter littlesmg88
• Start date Start date Aug 26, 2015
• Tags Tags adderall l-tyrosine

littlesmg88

Newbie Messages 140 I've seen mentions of taking the supplement L-tyrosine to help with dopamine. When should I take it? With my adderall, coming down from adderall, or when I'm on adderall vacations? THANKS!

Benzeneringz

Titanium Member Messages 166 Great question. L-tyrosine is a non-essential amino acid that acts as a precursor to dopamine, norepinephrine and epinephrine. It also helps with the synthesis of threonine (a thyroid hormone) and converts in the skin to melanin, which is a protectant against UV damage. Why is L-tyrosine relevant to an amphetamine user? Amphetamines, such as Adderall, Dexedrine, and methamphetamine, cause a massive release of the neurotransmitter dopamine from storage vesicles located in the axon bulb of a presynaptic neuron. This release forces the dopamine into the synaptic cleft, where it is free to stimulate post-synaptic dopamine receptors and cause feelings of euphoria, enhanced vigilance, hyperlocomotion, and steryotypies (which are repetitive movements, such as picking of the skin). What this basically means is, amphetamine causes a massive spill of the feel-good neurotransmitter dopamine into the brain areas responsible for pleasure (among other things). There are several reasons why this is detrimental to a person's well-being following amphetamine use. For one thing, dopamine is responsible for everyday pleasures, like eating chocolate or watching a play or having sex. When the drug forces dopamine into the synaptic cleft from the vesicles in which it is stored, eventually it is degraded by an enzyme called monoamine-oxidase (MAO). This leaves you with some depleted vesicles, and an overall reduction in available dopamine. Without an adequate supply of dopamine, feelings of anhedonia (the inability to experience pleasure), depression, avolition, and loss of interests can begin to manifest. What can someone do to help their brain a little bit following amphetamine use? Take L-tyrosine. So to answer your question directly, before and after an amphetamine exposure is the proper time to receive benefits. BEFORE, so your dopamine levels are already at their peak, and AFTER, to help replenish the supply. HOWEVER, L-tyrosine is not like a drug that will work more effectively at higher doses. The body uses L-tyrosine at a constant rate (called a rate-limiting factor in biochemistry), so more won't work any better than the optimal amount. But what is the optimal amount, and when should you start taking it? Most L-tyrosine capsules come in strengths of 500 milligrams; there are powders that can contain 500-600 milligrams of active ingredient in a measured amount. Most scientific studies indicate that to receive the benefits, a dose of 1,000 milligrams, or 1 gram, of L-tyrosine a day is sufficient. This dose is best taken in the morning, and you should take it with a multi-vitamin since certain B-vitamins, copper, and a few other minerals aide in the biosynthesis of dopamine from L-tyrosine. Like I said, it's pointless to take 6 or 7 capsules when you start to "come down"... you only need two or so. My advice to you, and anyone else who uses amphetamines, is to incorporate L-tyrosine into your daily routine. I have personal experience with this, so I'm speaking truth. IT DOES MAKE A DIFFERENCE! I would take 1 to 2 grams of L-tyrosine as soon as I began to come down off of Adderall and I did notice a marked difference in the severity of the comedown, but also the length of time before I could feel that enjoyable feeling again. I could put my doses closer together and achieve euphoria instead of taking more and more, trying to force non-existent dopamine into my synapses and becoming psychotic as a result. So, in summation, L-tyrosine should ideally be taken BEFORE an amphetamine exposure, but at any point during the exposure a dose of L-tyrosine will help. Don't take a handful of capsules; you're wasting your money. You can, however, perhaps double the dose if you see the need. I saw no difference in the benefits of 1 gram compared to 2 grams post-exposure. Try to take a multi-vitamin with the L-tyrosine to really seal the biological deal, so to speak Hope this helps!

DiabolicScheme

Titanium Member Messages 1,171 Tyrosine should be taken on a empty stomach (dont eat for at least 30 minutes after) to prevent it from merging with other amino acids to build protein. Tyrosine is a precursor to L-Dopa in the body and is created by a rate limiting enzyme tyrosine hydroxylase. Rate limited means it will only create as much dopamine as it wants to. So taking more will not produce more dopamine. Don't expect it to be like amphetamine, its not. It will keep dopamine production at an optimal level though and it's pretty cheap to try it. I'd do it before breakfast and before lunch.

littlesmg88

Newbie Messages 140 Benzeneringz THANK YOU! Your information was very helpful and easy to understand! Currently due to PMS I've been feeling very depressed and nothing to feel excited about. I've been on adderall 11 years. Currently it's evening, I'm home from work, I'm tired and I feel kinda depressed, I'm looking for anything to take to make me feel good, excited, motivated, productive. Should I take 1000mg L-tyrosine now? Are you saying take it once daily- not in between doses? Also you said: " I would take 1 to 2 grams of L-tyrosine as soon as I began to come down off of Adderall and I did notice a marked difference in the severity of the comedown, but also the length of time before I could feel that enjoyable feeling again. I could put my doses closer together and achieve euphoria instead of taking more and more, trying to force non-existent dopamine into my synapses and becoming psychotic as a result." What doses were you putting closer together? I would like to know in order to achieve euphoria as well. I never really experience it anymore

DiabolicScheme

Titanium Member Messages 1,171 Tyrosine will not induce euphoria, its rate limited by the enzyme that converts it to dopamine. In other words, it won't go beyond what your brain considers normal so it won't cause a flood of dopamine (euphoria). More or less it'll help with the come down but it's not recreational at all. Tyrosine will ensure your brain is generating it's natural amount of dopamine. If youre looking to regain euphoria you need a drug holiday, take a week off. Please note that it is unlikely to ever induce the same euphoria you got when you first used it but it can come back in some form. Your brain will quickly adapt though and the euphoria will dissappear again unless you take regular breaks to keep tolerance down. Do not chase the high (known as chasing the dragon) because it will put you in a bad situation of addiction. You'll get to the point where you'll "need" it to feel normal and there will be no positive effects. While amphetamines don't have the same grade of addiction as opioids it still can be pretty psychologically addicting.

Benzeneringz

Titanium Member Messages 166 Yeah, L-Tyrosine itself doesn't cause euphoria. Littlesmg88, I was talking about spacing my Adderall doses closer together? Is that what you meant, what dosage and frequency were my Adderall doses? I wold have a supply of 60 of the 30 milligram IR tablets a month, so I had the means to take high dosages often. It doesn't really matter that much WHEN you take the L-tyrosine, it's more a matter of if you take it once a day. You'll start to feel benefits after two-three days, I'd imagine. That's when it started bolstering my dopamine. I know I had a more abundant supply of dopamine because if I took the L-tyrosine after coming down, the next day I could take the same amount and not have to account for severe tachyphlaxis (a depletion of neurotransmitters from a vesicle, which causes a form of tolerance)

littlesmg88

Newbie Messages 140

Benzeneringz said: Yeah, L-Tyrosine itself doesn't cause euphoria. Littlesmg88, I was talking about spacing my Adderall doses closer together? Is that what you meant, what dosage and frequency were my Adderall doses? I wold have a supply of 60 of the 30 milligram IR tablets a month, so I had the means to take high dosages often. It doesn't really matter that much WHEN you take the L-tyrosine, it's more a matter of if you take it once a day. You'll start to feel benefits after two-three days, I'd imagine. That's when it started bolstering my dopamine. I know I had a more abundant supply of dopamine because if I took the L-tyrosine after coming down, the next day I could take the same amount and not have to account for severe tachyphlaxis (a depletion of neurotransmitters from a vesicle, which causes a form of tolerance) Click to expand...

Yeah I tried taking L-tyrosine before I took my morning dose of adderall today and it didn't really do much. Yesterday I took it in the evening and it helped some. I took 1,000 mgs both days. I am wondering if I should try taking some before bed tonight to help replenish my dopamine for tomorrows morning adderall dose. But you mentioned taking more/frequent doses of l-tyrosine would not do anything? C

ChronicSmoker

Newbie Messages 4 By the way I'd like to add that I believe l tyrosine can cause euphoria, if you take 2 of them with a b6 vitamin(which helps it absorb) it'll make you feel not great like amphetamines but better than normal, especially if you're dopamine depleted. And also the main way you can really get euphoria from tyrosine is if you take it with coffee, it is actually very euphoric. Same with alcohol but Idk if I'd reccomend that

abuseforapie

Palladium Member Messages 557

ChronicSmoker said: By the way I'd like to add that I believe l tyrosine can cause euphoria, if you take 2 of them with a b6 vitamin(which helps it absorb) it'll make you feel not great like amphetamines but better than normal, especially if you're dopamine depleted. And also the main way you can really get euphoria from tyrosine is if you take it with coffee, it is actually very euphoric. Same with alcohol but Idk if I'd reccomend that Click to expand...

Taking L-tyrosine with caffeine can probably be pleasurable to an extent but whether or not it is placebo, I cannot say. I have noticed positive effects from L-Tyrosine, but only under certain conditions. L-Tyrosine and can serve as a nice intermediary for those who are taking a break from amphetamine consumption. It can also help for those who are taking amphetamine regularly for reasons already mentioned. I should mention that while L-Tyrosine and alcohol taken together might not necessarily be a harmful combination, be careful about taking alcohol in combination with stimulants as it can lead to cardiovascular and even neurological problems when done in excess. So please be careful and cautious if anybody reading this is contemplating this combination. Last edited: Sep 12, 2016 L

Lucygirl

Newbie Messages 3 Hello. I just wanted to make sure I understand about taking L Tyrosine with Adderall. I'm prescribed 60 mg (3-20 mg tabs) 1st thing in the morning of IR Adderall & 2 tabs (20 mg) At lunch. Which by 6:00-7:00 I'm tired & don't feel like doing much. I'm prescribed Adderall for Chronic Fatigue Syndrome & other diagnosis I have that cause chronic fatigue. I was reading your post about taking L Tyrosine with Adderall. According to my dosages of Adderall, would you still take the L Tyrosine in the morning with a vitamin? If I take vitamins w/o food it makes me nauseated. I've noticed taking 1000 mg at one time bothers my stomach so I take 500 mg in the morning after I take my Synthroid & 500 mg before lunch. Do you think it's ok to take L Tyrosine if you take Synthroid? Mainly concerned as to when to take L Tyrosine while taking Adderall. New on here so I hope I'm asking the question correctly. Thanks for any advice you could give me!! Lucygirl added 4 Minutes and 26 Seconds later... I was directing my question to Benzeneringz. Thanks!!! Last edited: Oct 18, 2016

mygreenbic

Silver Member Messages 108 Some people advise taking l-tyrosine late day (after last dose of adderall starts to come down) or before bed if tolerable as to replenish depleted l-tyrosine stores and possibly some other dopaminergic precursors. Try glycine also at night. If l-tyrosine is too difficult for you to take late day give NALT (N-Acetyl L Tyrosine) a try. Although many say it isnt as effective, it is more bioavailable and easier for one to take who may be vulnerable to side effects. Post reply

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