Devil May Cry 5 | DMC5 Mission 2 - Story Mission Walkthrough

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Check out this Devil May Cry 5 (DMC 5) main story walkthrough and guide for Mission 2 - Qliphoth. This includes gameplay and battle tips, mission tricks and techniques, and more.

Mission Progression & Walkthrough

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Mission 1	Mission 3

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Table of Contents

Mission 2 - Walkthrough
Mission Tips & Tricks
Goliath Boss Tips & Strategy

Mission 2 - Walkthrough

Mission 2 - Walkthrough Chart

1	From the starting point, head straight till you get to the area with petrified humans
2	Follow the creature at the back end of the area to trigger a cutscene
3	Defeat the Empusas that appear
4	Continue past the wall, and vault over it
5	Head to the area with the Pegasus statue
6	Defeat the Hell Cainas
7	Enter the Chiaro Mondo Hotel
8	Clear the Empusa that spawn in the hotel and courtyard
9	Head up the Hotel and enter through the door on the right
10	Circle around the room to get to the door blocked by tentacles
11	After the cutscene, immediately head left and use the Nidhogg Hatchling on the obstacle
12	Pass through the new doorway, and head left to enter a building
13	Go up the stairs, and enter the room in the hall on the right side
14	Defeat the Hell Cainas that spawn
15	Continue along the path, and use a Nidhogg Hatchling to unblock your way
16	A tentacle will block your way, so head to the room to your right
17	Pass through the room's door, and enter the first doorway on your left
18	Defeat the Hell Cainas in the room
19	Go out of the room, and jump down from the balcony
20	Head to the right side of the Crossroads, and get the Nidhogg Hatchling
21	Head back to the blocked area to trigger a cutscene
22	Defeat the Hell Antenoras that spawn
23	Use the Nidhogg Hatchling on the blocked area
24	Continue down the path, and head to the phone booth to call Nico
25	After customizing, head up the path, behind the van to trigger a cutscene
26	Defeat Goliath to trigger a cutscene

Mission 2 Tips & Tricks

3, 8. Defeating Empusa - Tips

Focus On One Enemy At A Time

Empusas are not very fast enemies. You can easily handle them by focusing on one enemy at a time. When you see more enemies getting too close, relocate further away, and pull one closer to you.

3. Find Gold Orb To Right Of Defeating Empusas

Devil May Cry 5 Gold Orb Location Mission 2

After the battle, you can find a Gold Orb by double jumping over the raised piece of road to the right of the area where you first fought the Empusas. The Gold Orb is at the dead end of the area.

Check Out All Gold Orb Locations Here!

3. Take Right Path To Find "Where Red Orbs Grow" Achievement

Devil May Cry 5 Where Red Orbs Grow Achievement Location

After defeating the Empusas and moving forward, the path will split into two. Take the right path & jump up the ledge. Go into the hole in the wall and into a small room. Break the red orbs growing on trees here to get the trophy "Where The Red Orbs Grow".

6, 14, 18. Defeating Hell Cainas - Tips

Easy To Dodge Attacks Cause Of Slow Wind Up

Hell Cainas have a slow wind up, which makes them easy to dodge. You can read them telegraphing their attacks when they start to lift their scythes behind them. When they do this, dodge out of the way to avoid getting hit.

14. After Defeating Hell Cainas - Tips

Collect Blue Orb Fragment

At a room where Nidhogg is located, the floor will break down while combat, and create a hole. This floor holds a Blue Orb Fragment that you can get.

Check Out How To Collect Blue Orb Fragments

16. In The Room To Your Right - Tips

Secret Mission Available

The wall around the doorway will have a symbol drawn onto it. Align it correctly to unlock and complete the Secret Mission 01.

20. Before Getting The Nidhogg Hatchling - Tips

Collect Blue Orb Fragment

Before making a left to the Nidhogg Hatchling, you will find a Devil Breaker on the right side of the path. Jump up onto the platform, and into an opening on the building to find a Blue Orb Fragment waiting for you.

Check Out How To Collect Blue Orb Fragments

22. Defeating Hell Antenoras - Tips

Slow, But Long Attacks

Hell Antenoras are generally slow, but they have a string of attacks. Do not get close to them until they finish their attacks so as to avoid getting hit.

24. Calling Nico - Tips

Customize As Soon As She Appears

Once Nico appears, you will have the chance to customize your loadout. Make sure that you do since this is your last chance to stock up on equipment before fighting Goliath.

Goliath Boss Tips & Strategy

Check Out Goliath Boss Fight Guide Here!

Telegraphs His Attacks

Goliath's attacks are pretty easy to dodge due to their slow wind up. When he starts his attack animation, stop your combo, dodge out of the way.

Steer Clear Of His Fire Vacuum Attack

Goliath will also attack with fire from his belly that will suck in anything in its path. It is best to run away from the Fire Vacuum's direction, and Break Away when you are caught.

Collect Green Orbs When Low On Health

When you are low on health, it is best to keep an eye out for Green Orbs in the area to restore some of your health. It is best only to collect these, when your health is dangerously low.

Use Guns To Chip Away At His Health

There are times when Goliath will not let you near him because of his attacks. If you are far away, you can use your guns to chip away at his health.

Charge Up Devil Breakers To Deal Massive Damage

You can charge up your Devil Breakers to deal a ton of damage to the Goliath. It is best to use the Gerbera since it can shoot a laser beam from far away.

Mission Progression & Walkthrough

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Mission 1	Mission 3

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Mission Walkthrough

All Mission Guide

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Spoiler! Unlock The Secret Ending Guide

Game Modes

The Void

Bloody Palace

Beginner's Tips & Guide

Character Information

Nero Gameplay Guide	Dante Gameplay Guide
V Gameplay Guide	Controls & Character Movesets
Dante Style Change Guide	-

Playable Characters

Game Database

All Weapon List	All Devil Breakers List
All Orb List	Item Shop List
All Consumable Item List	Trophy Unlock List

Useful Information

Beginner Tips & Guide	Recommended Abilities To Unlock
What To Do When The Game Gets Too Difficult	Differences Between Difficulty Levels
How To Get S Rank	How To Unlock The Secret Ending
How To Get A Better Style Rank	-

Boss Guide & Tips

Goliath Boss Fight	Vergil Boss Fight
Urizen Boss Fight	Malphas Boss Fight
King Cerberus Boss Fight	Cavaliere Angelo Boss Fight
Miraggio Angelo Boss Fight	Gilgamesh Boss Fight
Elder Geryon Knight Boss Fight	-