Driving Directions - Rochester, MN

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In this section: Visit Mayo Clinic
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Highways

Rochester is easily accessible by highway. East-West highway routes: Interstate 90, US Hwy 14, State Hwy 30, State Hwy 42, State Hwy 296. North-South highway routes: Interstate 35, US Hwy 52, US Hwy 63.

Rochester is centrally located in the Upper Midwest with sixteen major metropolitan areas less than 550 miles away.

  • Minneapolis, MN - 76 miles
  • Madison, WI - 202 miles
  • Milwaukee, WI - 287 miles
  • Chicago, IL - 355 miles
  • Des Moines, IA - 208 miles
  • Sioux Falls, SD - 239 miles
  • Lincoln, NE - 392 miles
  • Kansas City, MO - 427 miles

Directions to Rochester MN

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