Enterogastric Reflex - Wikipedia

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• 1 Emptying inhibitory factors
• 2 Emptying stimulatory factors
• 3 References

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Appearance move to sidebar hide From Wikipedia, the free encyclopedia Reflex inhibiting stomach emptying

This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Enterogastric reflex" – news · newspapers · books · scholar · JSTOR (May 2022)

The enterogastric reflex is one of the three extrinsic reflexes of the gastrointestinal tract, the other two being the gastroileal reflex and the gastrocolic reflex.[1] The enterogastric reflex is stimulated by duodenal distension.[2] It can also be stimulated by a pH of 3-4 in the duodenum and by a pH of 1.5 in the stomach. Upon initiation of the reflex, the release of gastrin by G-cells in the antrum of the stomach is shut off. This in turn inhibits gastric motility and the secretion of gastric acid (HCl).[1]

Emptying inhibitory factors

[edit]

The stomach's contents are inhibited from emptying into the small intestine by:

• duodenal distension[3][2]
• duodenal acidic pH[4]
• duodenal hypertonicity[5][6]
• increased osmolarity of gastric chyme[5][6]
• sympathetic stimulation[citation needed]
• intense pain[citation needed]
• Cholecystokinin, Secretin, Vasoactive intestinal peptide
• Nitric oxide, somatostatin from D cells

Emptying stimulatory factors

[edit]

The stomach's contents empty through the pylorus, allowing digestion to proceed, when there is:

• parasympathetic stimulation[citation needed]
• increased volume and fluidity of gastric contents[7]

References

[edit]

1. ^ a b "Gastrointestinal Reflex Pathways". LibreTexts. 22 July 2018. Retrieved 27 October 2019.
2. ^ a b "Enterogastric Reflex". Encyclopedia.com. Retrieved 27 October 2019.
3. ^ Holzer, H. H.; Raybould, H. E. (April 1992). "Vagal and splanchnic sensory pathways mediate inhibition of gastric motility induced by duodenal distension". American Journal of Physiology. Gastrointestinal and Liver Physiology. 262 (4): G603 – G608. doi:10.1152/ajpgi.1992.262.4.G603. PMID 1566842.
4. ^ Hunt, J. N.; Knox, M. T. (1969). "The slowing of gastric emptying by nine acids". The Journal of Physiology. 201 (1): 161–179. doi:10.1113/jphysiol.1969.sp008749. PMC 1351638. PMID 5773550.
5. ^ a b "Factors That Regulate Gastric Emptying". Physiology Plus. Archived from the original on 2019-04-27. Retrieved 22 November 2019.
6. ^ a b Meeroff, J. C.; Go, V. L.; Phillips, S. F. (May 1975). "Control of gastric emptying by osmolality of duodenal contents in man". Gastroenterology. 68 (5 Pt 1): 1144–51. doi:10.1016/S0016-5085(75)80228-9. PMID 1126594. Retrieved 23 November 2019.
7. ^ "Nervous System of the Digestive System - Gastrointestinal Reflex Pathways". Boundless. Retrieved 31 March 2016.

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