Epuris (Isotretinoin Capsules): Uses, Dosage, Side Effects ... - RxList

What Is Epuris?

Epuris (isotretinoin) is a retinoid used to treat severe nodular and/or inflammatory acne, acne conglobate, and recalcitrant acne

What Are Side Effects of Epuris?

Side effects of Epuris include:

• dry or chapped lips,
• dry skin,
• back pain,
• dry eyes,
• joint pain,
• nosebleed,
• headache,
• runny or stuffy nose,
• dermatitis,
• increased blood creatine kinase,
• inflammation of the lips,
• musculoskeletal discomfort or pain,
• upper respiratory tract infection,
• vision problems,
• dry nose,
• fatigue,
• increased blood triglycerides,
• eczema,
• rash,
• decreased bone density,
• neck pain,
• pain in extremities,
• nausea,
• insomnia,
• muscle strain, and
• mouth pain.

Dosage for Epuris

The initial dose of Epuris should be individualized according to the patient’s weight and severity of the disease. In general, patients initially should receive Epuris 0.5 mg/kg body weight daily for a period of two to four weeks. The maintenance dose should be adjusted between 0.1 and 1 mg/kg body weight daily and, in exceptional instances, up to 2 mg/kg body weight daily, depending upon individual patient response and tolerance to the drug. A complete course of therapy consists of 12-16 weeks of Epuris administration.

Epuris In Children

The use of Epuris in pediatric patients less than 12 years of age is not recommended.

The use of Epuris for the treatment of severe recalcitrant nodular acne in pediatric patients ages 12 to 17 years should be given careful consideration, especially for those patients where a known metabolic or structural bone disease exists.

What Drugs, Substances, or Supplements Interact with Epuris? Epuris may interact with other medicines such as:

• tetracyclines,
• supplements containing vitamin A,
• phenytoin,
• norethindrone/ethinyl estradiol,
• microdosed progesterone preparations (minipills),
• systemic corticosteroids, and
• St. John’s wort.

Tell your doctor all medications and supplements you use.

Epuris During Pregnancy and Breastfeeding

Epuris is not recommended for use during pregnancy; there is a high risk of severe birth defects in the fetus. Female patients of childbearing potential must have two negative pregnancy tests before starting Epuris therapy. Effective contraception must be used for at least one month before starting Epuris treatment, during treatment and for at least one month following the discontinuation of Epuris treatment. It is recommended that two reliable forms of contraception be used simultaneously. It is unknown if Epuris passes into breast milk. Because of the potential for adverse effects, breastfeeding is not recommended while using Epuris.

Additional Information

Our Epuris (isotretinoin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.