How Evolution Builds Genes From Scratch | Semantic Scholar

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• DOI:10.1038/d41586-019-03061-x
• Corpus ID: 204707405

How evolution builds genes from scratch@article{Levy2019HowEB, title={How evolution builds genes from scratch}, author={Adam Levy}, journal={Nature}, year={2019}, volume={574}, pages={314 - 316}, url={https://api.semanticscholar.org/CorpusID:204707405} }

• Adam Levy
• Published in Nature 16 October 2019
• Biology, Environmental Science

Scientists long assumed that new genes appear when evolution tinkers with old ones. It turns out that natural selection is much more creative. Scientists long assumed that new genes appear when evolution tinkers with old ones. It turns out that natural selection is much more creative. 5-inch Arctic cod in hollows of ice floes in the Arctic Ocean 5-inch Arctic cod in hollows of ice floes in the Arctic Ocean View on Springer Naturencbi.nlm.nih.govSave to LibrarySaveCreate AlertAlertCiteShare22 CitationsHighly Influential Citations1Background Citations6View All

22 Citations

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Functional innovation through new genes as a general evolutionary process

Shengqian XiaJianhai ChenDeanna ArsalaJ. EmersonManyuan LongBiologyNature Genetics
• 2025

TLDRThe various molecular mechanisms underlying the generation of new genes are discussed and their important functions and phenotypes are highlighted with an emphasis on the evolutionary forces underlying natural selection and sexual conflict.Expand

• 16

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Evolution of Complexity. Molecular Aspects of Preassembly

F. MengerSyed A. A. RizviBiologyMolecules
• 2021

TLDRThis work states that genetic material required for many complex traits, such as echolocation, was present long before emergence of the traits, and that Epigenetic factors ultimately promoted transfers from noncoding to coding genes, leading to abrupt formation of the trait via de novo genes.Expand

• 2
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Evolutionary New Genes in a Growing Paradigm

E. BetránM. LongBiologyGenes
• 2022

TLDRHow new genes evolve has become an interesting problem in biology, particularly in evolutionary biology, and the search for new approaches to tackle this problem is under way.Expand

• 2
[PDF]

• 1 Excerpt

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Population genomics reveals mechanisms and dynamics of de novo proto-gene emergence in Drosophila melanogaster

Anne-Catherine GrandchampLucas KühlM. LebherzKathrin BrüggemannJ. ParschE. Bornberg-BauerBiologybioRxiv
• 2022

TLDRProto-genes have a high birth-death rate, are rapidly purged, but surviving proto-Genes spread neutrally through populations and within genomes.Expand

• 5
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Structural and functional characterization of a putative de novo gene in Drosophila

Andreas LangePrajal H. Patel+5 authors E. Bornberg-BauerBiologyNature Communications
• 2021

TLDRIt is shown that Goddard protein localizes to elongating sperm axonemes and that in its absence, elongated spermatids fail to undergo individualization, and Goddard protein contains a large central α-helix, but is otherwise partially disordered.Expand

• 58
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• 1 Excerpt

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A de novo-originated gene drives rose scent diversification.

Yajun LiRunhui Li+9 authors Guogui NingBiology, Environmental ScienceCell
• 2025

• 1

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Population genomics reveals mechanisms and dynamics of de novo expressed open reading frame emergence in Drosophila melanogaster

Anne-Catherine GrandchampLucas KühlM. LebherzKathrin BrüggemannJ. ParschE. Bornberg-BauerBiologyGenome research
• 2023

TLDRNeORFs have a high birth-death rate, are rapidly purged, but surviving neORFs spread neutrally through populations and within genomes, suggesting a rapid turnover.Expand

• 17
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NGATHA carpel development genes evolved in the common ancestor of seed plants

Ignacio CotaSilvia Moschin+7 authors S. PelazBiology, Environmental ScienceThe Plant journal : for cell and molecular…
• 2025

TLDRIt is found that Ginkgo biloba homologs can functionally substitute for their angiosperm counterparts in stigma development and that GbRAV5 is related to angiosperm NGA genes, challenging previous notions that these are exclusive to angiosperms.Expand

• 1
• Highly Influenced

• 5 Excerpts

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Evolution and implications of de novo genes in humans

Luuk A BroeilsJorge Ruiz-OreraB. SnelN. HubnerSebastiaan van HeeschBiologyNature Ecology & Evolution
• 2023

TLDRThrough manual curation of literature and databases, this work provides a thorough table with most de novo genes reported for humans to date and re-evaluate each locus by tracing the enabling mutations and list proposed disease associations, protein characteristics and supporting evidence for translation and protein detection.Expand

• 46

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Mosaic translation hypothesis: chimeric polypeptides produced via multiple ribosomal frameshifting as a basis for adaptability

Umut ÇakırNoujoud GabedM. BrunetX. RoucouIgor S. KryvoruchkoBiologyThe FEBS journal
• 2021

TLDRIt is hypothesize that this mechanism may have contributed to the flexibility and adaptability of organisms to a variety of environmental conditions and may be the main source of protein diversity in genomes that lack alternative splicing.Expand

• 7

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17 References

Citation TypeHas PDFAuthorMore FiltersMore FiltersFiltersSort by RelevanceSort by Most Influenced PapersSort by Citation CountSort by Recency

Inverse relationship between evolutionary rate and age of mammalian genes.

M. AlbàJ. CastresanaBiologyMolecular biology and evolution
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TLDRIt is shown that older genes tend to evolve more slowly than newer ones; that is, proteins that arose earlier in evolution currently have a larger proportion of sites subjected to negative selection.Expand

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Proto-genes and de novo gene birth

Anne-Ruxandra CarvunisT. Rolland+13 authors M. VidalBiologyNature
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TLDRThis work formalizes an evolutionary model according to which functional genes evolve de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences and demonstrates that evolution exploits seemingly dispensable sequences to generate adaptive functional innovation.Expand

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De Novo Gene Evolution of Antifreeze Glycoproteins in Codfishes Revealed by Whole Genome Sequence Data

H. T. BaalsrudO. K. Tørresen+4 authors S. JentoftBiology, Environmental ScienceMolecular biology and evolution
• 2017

TLDRIt is demonstrated that afgps in codfishes have evolved de novo from non‐coding DNA 13–18 Ma, coinciding with the cooling of the Northern Hemisphere, and evolution of afgp‐assisting antifreeze potentiating protein genes (afpps) in notothenioids coincides with origin and lineage‐specific losses of af gp.Expand

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De Novo Origin of Human Protein-Coding Genes

Dong-Dong WuD. IrwinYa-ping ZhangBiologyPLoS genetics
• 2011

TLDRRNA–seq data indicate that 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability.Expand

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Origin of primate orphan genes: a comparative genomics approach.

Macarena Toll-RieraN. Bosch+4 authors M. AlbàBiologyMolecular biology and evolution
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TLDRIt is determined that codon usage values for most orphan genes fall within the bulk of the codon used distribution of bona fide human proteins, supporting their current protein-coding annotation and obtaining evidence that a small fraction of primate orphan genes might have originated de novo from mammalian noncoding genomic regions.Expand

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Evidence for de Novo Evolution of Testis-Expressed Genes in the Drosophila yakuba/Drosophila erecta Clade

D. BegunH. LindforsA. KernCorbin D. JonesBiologyGenetics
• 2007

TLDRTestis-derived expressed sequence tags from Drosophila yakuba are used to identify genes that have likely arisen either in D. yakuba or in the D. erecta ancestor, and several genes are found, which show testis-biased expression and are often X-linked.Expand

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Creating sense from non-sense DNA: de novo genesis and evolutionary history of antifreeze glycoprotein gene in northern cod fishes (gadidae)

Zhuang XuanBiology, Environmental Science
• 2013

TLDRThis work constructed large insert genomic DNA BAC (bacterial artificial chromosome) libraries of two gadids, the high Arctic polar cod Boreogadus saida and the coldtemperate Atlantic tomcod Microgadus tomcod, to isolate their AFGP genomic loci for analyses and identified three distinct AFGP gene clusters.Expand

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From De Novo to “De Nono”: The Majority of Novel Protein-Coding Genes Identified with Phylostratigraphy Are Old Genes or Recent Duplicates

C. CasolaBiologyGenome biology and evolution
• 2018

TLDRNearly half of the de novo genes confirmed in this study are within older genes, indicating that co-option of preexisting regulatory regions and a higher GC content may facilitate the origin of novel genes.Expand

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Recently Evolved Genes Identified From Drosophila yakuba and D. erecta Accessory Gland Expressed Sequence Tags

D. BegunH. LindforsM. ThompsonA. K. HollowayBiologyGenetics
• 2006

TLDRA genomic analysis of previously unknown genes isolated from cDNA libraries of these species revealed several cases of genes present in one or both species, yet absent from ingroup and outgroup species, which suggests the possibility that Acp's or other genes coding for small proteins may originate from ancestrally noncoding DNA.Expand

• 144
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De Novo Emergence of Peptides That Confer Antibiotic Resistance

Michael KnoppJónína S. Gudmundsdóttir+5 authors D. AnderssonBiology, ChemistrymBio
• 2019

TLDRIt is demonstrated that randomized DNA sequences can encode peptides that confer selective benefits and illustrates how expression of random sequences could spark the origination of new genes.Expand

• 46
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