How Long Does Medrol Dose Pack Take To Start Working?

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How soon you will start to feel your Medrol Dose Pack (methylprednisolone) working depends both on the individual taking it and what exactly you are taking it for.

For example, if you are taking it for the treatment of pain, say, low back or joint pain, it might take a few days to begin to notice the effects as inflammation subsides.

If you are taking it for the treatment of contact dermatitis, like poison ivy, you most likely will begin to feel better much faster, within 12 to 24 hours.

From a pharmacokinetic standpoint, which relates to measurable characteristics of drugs such as their absorption, distribution, and metabolism, methylprednisolone (the oral tablet form) is a fast-acting drug.

After taking it by mouth, it is rapidly absorbed and peak concentrations in the blood are reached within 1-2 hours.

However, just because it is absorbed from the GI tract and reaches the bloodstream quickly, this doesn't necessarily mean you'll notice the effects that fast.

The most common side effect of the Medrol Dose Pack is nausea. Taking it with food can help to reduce the incidence of it.

Other common side effects include:

  • Hyperglycemia (increased blood sugar)
  • Heartburn
  • Insomnia
  • Increased appetite
  • Weight gain
  • Insomnia
  • Mood changes
  • Increased or decreased energy

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