How Long Does Psilocybin Stay In Your System?

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How long does psilocybin stay in your system?

Magic mushrooms and the psilocybin in them are usually quickly metabolized by the body and excreted, sometimes in as fast as 3-15 hours. However, there are large differences between metabolism rates in individuals, which contributes to some contradictory evidence.

When mushrooms are ingested, the liver quickly converts some of its psilocybin into psilocin, the compound that’s actually responsible for the psychoactive effects.

The half-life of psilocin is 50 minutes. As it takes five to six half-lives for a substance to be mostly cleared from the body, psilocin is largely gone within four to five hours. One study found that approximately two-thirds of the renal excretion of psilocin is complete within three hours but also registered large differences between individuals.[1]

However, the half-life of remaining unconverted psilocybin is longer, at 163 minutes. Some evidence suggests it can take 15 hours to clear from the body. Another study found that the majority (80-85%) is excreted within eight hours.[2] However, a small amount (15-20%) may remain, stored in fatty tissue before being excreted in urine a week later.[3]

Small amounts of psilocybin and its metabolites will also be stored in hair follicles, where it can be detected for up to 90 days.

Read here for more information on how long hallucinogens stay in your system.

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