Ibuprofen Vs. Acetaminophen: What's The Difference? - Healthline

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HealthlineSubscribeIbuprofen vs. Acetaminophen: How Are They Different?

Medically reviewed by Lindsay Slowiczek, PharmD — Written by University of Illinois — Updated on August 29, 2018

Drug features
Brands
Ages
Cost and availability
Side effects
Drug interactions
Warnings
Takeaway

Acetaminophen belongs to a class of drugs called analgesics. Ibuprofen belongs to the drug class called nonsteroidal anti-inflammatory drugs (NSAIDs).

Acetaminophen and ibuprofen are both used to treat pain and fever, but Ibuprofen also decreases inflammation. Read on to learn more about their similarities and differences.

Acetaminophen vs. ibuprofen

Acetaminophen and ibuprofen come in many different forms, including:

oral tablets
oral capsules
oral suspension
chewable tablets

Ibuprofen also comes in concentrated oral drops. Acetaminophen comes in these other forms:

oral elixir
oral solution
extended-release oral tablets and caplets
rectal suppositories
rapid melt tablets
effervescent tablets

Brand-name versions

You may know acetaminophen as the brand-name drug Tylenol. A common brand name for ibuprofen is Advil. More brand names for these drugs are listed below.

Brand names for acetaminophen	Brand names for ibuprofen
Acephen	Advil
FeverAll	ElixSure
Mapap	Ibuprom
NeoPAP	Ibutab 200
Tylenol	Midol
Motrin
Tab-Profen

In children

Both drugs may be used in infants, children, and adults. Ibuprofen can be used in people who are 6 months or older. Acetaminophen can be used for people of any age, but you should talk to your child’s doctor before using it if your child is younger than 2 years.

Infants and young children can be given liquid forms and suppositories. Older children, who can chew and swallow more easily, may take the chewable or orally disintegrating tablets. Strength and dosage vary according to age, so always check the product instructions for exact amounts.

Cost and availability

Acetaminophen and ibuprofen are available in every pharmacy. They’re relatively affordable. GoodRx can give you an idea of specific prices in stores near you.

Side effects

The side effects of acetaminophen and ibuprofen may differ. This is because your body breaks them down differently.

For example, acetaminophen is broken down and removed by the liver. Acetaminophen has a warning about liver damage it can cause that can be fatal (cause death). Liver damage can happen if you take too much in a 24-hour period. You shouldn’t take more than one product that contains acetaminophen at once. For more information, read about the dangers of acetaminophen overdose.

Ibuprofen, on the other hand, is removed from your body by your kidneys. Taking it for a long time can cause kidney damage and stomach bleeding. Using high doses of ibuprofen for longer than recommended can increase your risk of:

blood clots
heart attack
stroke

Check out examples of side effects of acetaminophen and ibuprofen below.

Common side effects	Acetaminophen	Ibuprofen
nausea	✓	✓
vomiting	✓
headache	✓
trouble sleeping	✓	✓
pain above your stomach	✓
heartburn	✓

Serious side effects	Acetaminophen	Ibuprofen
allergic reactions	✓	✓
liver damage	✓	✓
kidney damage	✓	✓
sores or white spots on your lips or mouth	✓
heart attack or stroke	✓
stomach bleeding	✓
edema (fluid buildup in your body)	✓

Drug interactions

Acetaminophen and ibuprofen can cause dangerous interactions when you take them with certain medications. To reduce your risk, make sure you tell your doctor about all drugs, supplements, and herbs you take.

Both acetaminophen and ibuprofen can interact with alcohol and the blood thinner warfarin.

Acetaminophen also interacts with:

aprepitant
carbamazepine
cholestyramine
dasatinib
fosaprepitant
imatinib
isoniazid
lamotrigine
metyrapone
phenobarbital
phenytoin
probenecid
sorafenib

Ibuprofen also interacts with:

aspirin
enalapril
furosemide hydrochlorothiazide
ketoralac
lisinopril
lithium

Use with certain medical conditions

Taking either acetaminophen or ibuprofen may cause problems if you have certain health issues. Talk to your doctor before using acetaminophen or ibuprofen if you have:

a history of blood clots
liver disease
kidney disease

You should also talk to your doctor before using acetaminophen if you have:

glucose-6-phosphate-dehydrogenase (G6PD) deficiency
phenylketonuria

Ibuprofen can cause issues in people who have:

a history of bleeding or ulcers in their stomach or intestines
asthma, especially if it’s aspirin-sensitive
heart disease
high blood pressure
anemia
blood clotting disorders

Talk with your doctor

Acetaminophen and ibuprofen both treat pain, but they work slightly differently in your body. They’re available in different forms and strengths. Each drug can pose different safety issues, especially if you have existing health conditions. If you’re still not sure if one of these drugs is a good option for you, talk to your doctor.

How we reviewed this article:

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

Acetaminophen.(2014, August)https://www.nlm.nih.gov/medlineplus/druginfo/meds/a681004.html
Acetaminophen(oral route, rectal route): Side effects. (2015, December)http://www.mayoclinic.org/drugs-supplements/acetaminophen-oral-route-rectal-route/side-effects/drg-20068480
Acetaminophen (paracetamol):Pediatric drug information. (n.d.). UpToDatehttp://www.uptodate.com/contents/acetaminophen-paracetamol-pediatric-drug-information?source=search_result&search=acetaminophen&selectedTitle=2~150#F129293
Fresenius Kabi, USA. (2015, October). Highlights of prescribinginformation: Acetaminophen injection, for intravenous use. Lake Zurich, IL.Retrieved fromhttp://www.accessdata.fda.gov/drugsatfda_docs/label/2015/204767s000lbl.pdf
GoodRx. (2016, June). Acetaminophenhttp://www.goodrx.com/acetaminophen
GoodRx.(2016, June). Ibuprofenhttp://www.goodrx.com/ibuprofen?drug-name=ibuprofen
GoodRx.(2016, June). Ibuprofen non-prescriptionhttp://www.goodrx.com/ibuprofen-non-prescription?drug-name=ibuprofen+non-prescription
Ibuprofen(oral route): Side effects. (2016, January)http://www.mayoclinic.org/drugs-supplements/ibuprofen-oral-route/side-effects/drg-20070602
Johnson & Johnson Consumer Inc. (n.d.). TylenolRegular Strength Liquid Gelshttps://www.tylenol.com/products/headache-muscle/tylenol-regular-strength-liquid-gels
Johnson & Johnson Consumer Inc. (2015, July). TylenolRegular Strength – acetaminophen tablethttps://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=1622f694-4d63-4c56-8737-fae31f0ecfb7&type=pdf&name=1622f694-4d63-4c56-8737-fae31f0ecfb7
Johnson & Johnson Consumer Inc. (2015,September). Motrin IB – ibuprofen tablet, film coatedhttps://dailymed.nlm.nih.gov/dailymed/getFile.cfm?setid=5bca517f-94a5-428c-b716-80c6b0b86980&type=pdf&name=5bca517f-94a5-428c-b716-80c6b0b86980
Pfizer,Inc. (2007, January). Motrin: Ibuprofen tablets, USPhttp://www.accessdata.fda.gov/drugsatfda_docs/label/2007/017463s105lbl.pdf
Upstate UniversityHospital Oncology Services. (2015, March). Fever and neutropenia. Syracuse, NY.Retrieved from http://www.upstate.edu/forms/documents/F81358.pdf
Wilkinson, J.J. (2015). Headache. In D. L. Krinsky, S. P. Ferreri, B. A. Hemstreet,A. L. Hume, G. D. Newton, C. J. Rollins, & K. J. Tietze (eds.), Handbook of nonprescription drugs: Aninteractive approach to self-care (18th ed.), 63-81. Washington, DC: American Pharmacists Association.

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Medically reviewed by Lindsay Slowiczek, PharmD — Written by University of Illinois — Updated on August 29, 2018

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