Infectious Mononucleosis Skin Rash Without Previous Antibiotic Use

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The Brazilian Journal of Infectious Diseases ISSN: 1413-8670

The Brazilian Journal of Infectious Diseases is the official publication of the Brazilian Society of Infectious Diseases (SBI). It aims to publish relevant articles in the broadest sense on all aspects of microbiology, infectious diseases and immune response to infectious agents. The BJID is a bimonthly publication and one of the most influential journals in its field in Brazil and Latin America with a high impact factor. Since its inception it has garnered a growing share of the publishing market.

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See more SNIP 2024 0.738 View more metrics Open Access Option Hide Journal Information Previous article | Next article Vol. 19. Issue 5.Pages 553 (September - October 2015) Export reference Share Share Twitter Facebook Bluesky Linkedin whatsapp E-mail Print Download PDF More article options Statistics Vol. 19. Issue 5.Pages 553 (September - October 2015) Clinical image DOI: 10.1016/j.bjid.2015.04.005 Open Access Infectious mononucleosis skin rash without previous antibiotic use Visits 44241 Download PDF Theocharis Koufakis Corresponding author thkoyfak@hotmail.comCorresponding author at: 49 Ioustinianou Str., P.C. 41223, Larissa, Greece. , Ioannis GabranisDepartment of Internal Medicine, General Hospital of Larissa, Larissa, Greece This item has received 44241 Visits 3 Cites Under a Creative Commons license Article information Full Text Bibliography Download PDF Statistics Figures (1) Full Text

A 20-year-old female patient presented with fever, pharyngitis and lymphadenopathy. The diagnosis of infectious mononucleosis was established by high levels of IgM antibodies against the Epstein–Barr virus. Fifteen days after the onset of symptoms she developed a maculopapular generalized rash (Fig. 1), which resolved within a few days, without any special treatment. She had not received antibiotics or any other drug.

Fig. 1.

Maculopapular generalized rash on patient's back.

Patients with infectious mononucleosis may present with a non pruritic, faint rash during the course of the disease, which is believed to be caused directly by the virus. This is in contrast with the rash observed in patients who received beta-lactam antibiotics, mainly ampicillin or amoxicillin, which is associated with a hypersensitivity reaction to the antibiotic1 and it is usually pruritic and prolonged. Other, less common, skin manifestations of infectious mononucleosis include, among others, erythema nodosum, erythema multiforme, and urticaria.2 Our patient completely recovered within 3 months, with no complications.

Conflicts of interest

The authors declare no conflicts of interest.

References[1]I. Banerjee, S. Mondal, S. Sen, S.K. Tripathi, G. Banerjee.Azithromycin-induced rash in a patient of infectious mononucleosis – a case report with review of literature.J Clin Diagn Res, 8 (2014), pp. HD01-HD02 http://dx.doi.org/10.7860/JCDR/2014/9499.5015 | Medline[2]V. Di Lernia, Y. Mansouri.Epstein–Barr virus and skin manifestations in childhood.Int J Dermatol, 52 (2013), pp. 1177-1184 http://dx.doi.org/10.1111/j.1365-4632.2012.05855.x | Medline Copyright © 2015. Elsevier Editora Ltda.. All rights reserved

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  • All metrics

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