Meiotic Synapsis - Reactome

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Meiotic synapsis

Stable Identifier R-HSA-1221632 Type Pathway Species Homo sapiens Compartment nucleoplasm, nuclear envelope ReviewStatus 5/5 Locations in the PathwayBrowser Expand all Cell Cycle (Homo sapiens)

• • Meiosis (Homo sapiens)
    • Meiotic synapsis (Homo sapiens)

Reproduction (Homo sapiens)

• • Meiosis (Homo sapiens)
    • Meiotic synapsis (Homo sapiens)

General SBML | BioPAX Level 2 Level 3 | PDF SVG | PNG Low Medium High | PPTX | SBGN Click the image above or here to open this pathway in the Pathway Browser Meiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form along chromosomes. Telomeres then cluster at a region of the inner nuclear membrane and axial elements extend and fuse along the length of the chromosomes. Subsequent to the initiation of recombination transverse filaments of SYCP1 link axial/lateral elements to a central element containing SYCE1 and SYCE2, thus forming the synaptonemal complex (reviewed in Yang and Wang 2009).Unsynapsed regions are silenced during pachynema by recruitment of BRCA1 and ATR, which phosphorylates histone H2AX (reviewed in Inagaki et al. 2010). Literature References

PubMed ID	Title	Journal	Year
18948708	The Mammalian synaptonemal complex: a scaffold and beyond Yang, F, Wang, PJ	Genome Dyn	2009
20364103	DNA double strand break repair, chromosome synapsis and transcriptional silencing in meiosis Inagaki, A, Schoenmakers, S, Baarends, WM	Epigenetics	2010

Participants Events

• Formation of axial/lateral elements of Synaptonemal Complex (Homo sapiens)
• Telomeres cluster at the nuclear membrane (Homo sapiens)
• Synapsis (Homo sapiens)
• BRCA1 is recruited to unsynapsed regions (Homo sapiens)
• ATR Kinase is recruited to unsynapsed regions (Homo sapiens)
• ATR phosphorylates Histone H2A.X at unsynapsed regions (Homo sapiens)

Participates as an event of

• Meiosis (Homo sapiens)

Authored May, B (2011-02-25) Reviewed Bolcun-Filas, E (2011-02-25) Cohen, PE (2011-02-05) Holloway, JK (2011-02-05) Lyndaker, A (2011-02-25) Schimenti, JC (2011-02-05) Strong, E (2011-02-25) Created May, B (2011-02-25)

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