Puppy Vaccine Schedule For First-Year Shots [PDF Chart]

Vaccinating your puppy is one of the most important things you’ll need to do in your first few weeks as a dog owner. Regular vaccinations will help your puppy grow into a dog free of potentially fatal diseases that can infect other pets or people.

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But what shots do puppies actually need? And at what age should puppies have all their shots by?

Here’s what you need to know about first-year puppy shots:

• Puppy Vaccine Checklist
• What shots do puppies need?
• Puppy Vaccine Schedule
• When do puppies get their first shots?
• When should puppies have all their shots by?
• When do puppies need booster shots?
• How much are puppy shots?
• Key Takeaways
• FAQs on Puppy Shots

Use the chart below to keep track of your puppy vaccinations, or download the puppy shot checklist PDF to print and follow along at home.

What shots do puppies need?

Core vaccines should be given to all puppies. According to AAHA, core vaccines include: distemper, hepatitis, parainfluenza, parvovirus, and rabies.

Distemper

Distemper is a contagious disease caused by a virus that attacks the nervous, respiratory, and gastrointestinal systems of dogs. Dogs usually become infected through airborne exposure (coughing or sneezing) from an infected dog or wild animal. The disease can also be transmitted by shared bowls, toys, and equipment.

Canine distemper is often fatal, and dogs that survive the disease are usually left with permanent damage to the nervous system. All dogs are at risk, but puppies under four months of age and unvaccinated dogs are at especially high risk.

Hepatitis (Adenovirus-2) Vaccine

Canine hepatitis is an acute infectious disease caused by the canine adenovirus 1. The virus targets the liver, lungs, kidneys, spleen, and eyes. Symptoms can include vomiting, fever, jaundice, swollen belly, loss of appetite, or, in more severe cases, seizures and death. Dogs that have the mild form of the disease enjoy a good quality of life and longevity, but the severe form can be fatal.

Parainfluenza Vaccine

Canine parainfluenza virus (CPIV) is a contagious respiratory virus and is one of the most common causes of kennel cough.

Canine Parvovirus (CPV-2) Vaccine

Canine parvovirus is a contagious virus that can affect all dogs, but puppies younger than four months old and unvaccinated dogs are the most at risk. The virus affects the gastrointestinal tract and is transmitted by direct contact, as well as contact with contaminated feces, people, or environments.

Some of the most common symptoms of parvo in puppies include loss of appetite, lethargy, fever, vomiting, abdominal pain, bloating, and diarrhea. There’s no cure for parvo, but with proper treatment, the survival rate in dogs treated by a veterinarian is between 68-92%.

Many vets now administer these four puppy vaccinations combined as one shot, known as the Distemper-Hepatitis-Parainfluenza-Parvo vaccine, administered incrementally over a puppy shot schedule as such:

DHPP Vaccine Schedule for Puppies

• 1st shot: 6-8 weeks
• 2nd shot: 10-12 weeks
• 3rd shot: 14-16 weeks
• 4th shot: 18-20 weeks
• 5th shot: 1 year
• Booster: every 3 years

Note: Newer recommendations are to vaccinate for DHPP out to 20 weeks due to lack of coverage close to the one-year mark for their booster, but ask your vet what they recommend for your puppy's vaccination schedule.

Rabies Vaccine

Rabies is a viral infection caused by a virus secreted in the saliva. According to the Humane Society, because the infection affects the nervous system, most rabid animals behave abnormally. Infected dogs typically become fearful, anxious, agitated, and/or aggressive. As there’s no cure for rabies, keeping up with regular vaccinations is crucial.

When should puppies get rabies shots?

Generally speaking, puppies should get their first rabies shot around 16 weeks of age and again between 1-3 years old. The rabies vaccine is mandatory throughout the US, but the timeline for a puppy schedule varies by state**. The vaccine must be administered by a licensed veterinarian (which means it can’t be found at a feed store).

Rabies Vaccine Schedule for Puppies

• 1st shot: 16-18 weeks
• 2nd shot: 1 year
• Booster: every 3 years

Non-core Vaccines

Non-core vaccines are important, but they are considered optional for dogs with less risk of infection. Non-core vaccines are recommended based on lifestyle and where you live or travel.

Bordetella

Bordetella bronchiseptica is a bacterium associated with respiratory disease in dogs and is known to cause the most severe form of kennel cough. Symptoms of an upper respiratory infection include nasal discharge, sneezing, coughing, congestion, etc.

Some veterinarians may recommend Bordetella as a core vaccine for puppies based on their living environment, especially for social dogs who spend time in areas where they might come into contact with the bacteria (like the dog park, boarding facilities, or doggy daycare). The vaccination can be given orally, intranasally, or by injection.

Bordetella Vaccine Schedule for Dogs

• 1st shot: 12-14 weeks
• 2nd shot: 1 year
• Booster: every year

Leptospira

Leptospirosis is a bacterial disease caused by infection of the genus Leptospira, which are found in water and soil. The zoonotic disease spreads easily from animals to humans and is more common in warm climate areas with high annual rainfall; the Leptospira vaccine may be considered core in these areas.

Signs of leptospirosis may include shivering, fever, muscle tenderness, increased thirst, dehydration, diarrhea, vomiting, lethargy, jaundice, kidney failure, liver failure, etc. When the disease is treated early and aggressively, the chances for recovery are quite good, but there’s still a risk of permanent kidney/liver damage.

Leptospira Vaccine Schedule for Puppies

• 1st shot: 12-14 weeks
• 2nd shot: 16-18 weeks
• 3rd shot: 1 year
• Booster: every year

There is also a 5-way vaccine known as DHLPP, which is a combination vaccine for distemper, hepatitis, leptospirosis, parainfluenza, and parvo.

Lyme disease

Lyme disease is caused by infection with the bacterium Borrelia burgdorferi which is transmitted through the bite of infected ticks. The most common symptoms in dogs include loss of appetite, lameness, joint swelling, swollen lymph nodes, and fatigue. More serious cases can also develop kidney complications.

The Lyme disease vaccine is highly recommended for dogs that live in or frequently travel to areas known for Lyme disease, as well as those living in areas with a high risk of tick exposure.

Lyme Vaccination Schedule for Puppies

• 1st shot: 10-16 weeks
• 2nd shot: 2-3 weeks later
• Booster: every year

Canine Influenza

Canine influenza, or dog flu, is a contagious viral infection affecting dogs. Two strains of canine influenza virus (CIV) have been identified in the US: H3N2 and H3N8.

The virus is spread through aerosols or droplets containing respiratory secretions from barking, sneezing, and coughing. Dogs in close contact with infected dogs in places like daycare facilities, groomers, and kennels are at a higher risk of contracting the disease. CIV causes an acute respiratory infection in dogs, with the most common clinical sign being a cough that persists for up to 21 days.

Vaccines are available for both H3N2 and H3N8 canine influenza. A bivalent vaccine offering protection against both strains is available as well.

Canine Influenza Vaccine Schedule For Puppies

• 1st shot: <16 weeks
• 2nd shot: 2-4 weeks later

Giardia

Giardia is a parasite that lives in dogs’ intestines and most often infects puppies and older dogs. Dogs become infected when they swallow the parasite that may be present in water or other substances that have been soiled with feces, leading to the disease Giardiasis. Giardia in dogs usually causes diarrhea, weight loss, or even death.

Giardia is an available vaccine for puppies 8 weeks of age and older for 6 months of immunity against giardiasis.

Coronavirus

The canine coronavirus is not in any way similar to COVID-19 in people. Canine coronavirus usually affects a dog’s GI system, but it can also cause respiratory infections. Most common symptoms include vomiting, diarrhea, and loss of appetite.

Young dogs are at a high risk of contracting the disease, so the vaccine is highly recommended for puppies under eight weeks. It’s usually not continued in puppies over eight weeks but may be based on your vet’s recommendation.

Rattlesnake vaccine

A rattlesnake vaccine can help dogs build antibodies to rattlesnake venom from bites that are often deadly and severely painful to dogs. The antibodies work to neutralize the venom, thereby significantly extending the window of time you have to take your dog to the emergency room, increasing their odds of survival.

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When do puppies get their first shots?

In general, puppies should get their first shots as soon as they are weaned (when they no longer receive antibodies from mom’s milk), or around 6 to 8 weeks of age. After that, puppies should receive a series of vaccines every two to four weeks (until actual protein can be achieved) between the ages of 6 and 20 weeks old.

Your vet will determine a safe vaccine schedule for your puppy based on their weight, health, age, etc. Some pet parents prefer getting multiple puppy shots in one vet visit to minimize stress on their pet, whereas others prefer to spread the shots out to reduce possible side effects and soreness — talk to your vet to create a safe vaccine schedule that works for you and your puppy.

Rabies depends on local laws but is usually given by the time your dog reaches 3 to 6 months old.

When should puppies have all their shots by?

Most vets prefer giving the final DHPP shot at 16 weeks or later; however, new recommendations suggest up to 20 weeks out.

When do puppies need booster shots?

Abstaining from booster shots can put your puppy at risk. However, not all vaccines require yearly boosters.

• DHPP vaccine booster: every two weeks for a total of three sets, then every three years
• Lepto, Canine influenza, and Lyme disease vaccine booster: one month after the initial series, then annually
• Bordetella booster: 1 year (or every 6 months where there is a concern)
• Rabies booster: every 1 to 3 years after the initial round, depending on state laws

Puppy Vaccine Schedule

There are several types of puppy shots your pet might get in their first year. In addition to a deworming schedule, your vet will suggest a vaccination schedule for puppies based on their age, environment, and medical history.

Most vets recommend this general timeline for first-year puppy shots:

6-8 weeks of age

Between 6-8 weeks old, puppies get their first shot of the DHPP (distemper, hepatitis, parainfluenza, parvovirus) vaccine. They might also receive their first round of vaccinations for Bordetella and Lyme disease.

10-14 weeks of age

Puppies get their next round of shots for DHPP, Bordetella, and Lyme disease about 4 weeks later, between 10-14 weeks old. Leptospira (Lepto) is a common puppy vaccination administered around this time frame.

16-20 weeks of age

Around 4 months old, puppies will receive their final round of DHPP, Bordetella, and Lyme disease, after which point they may be considered immunized and safe to go into public spaces — but be sure to ask your vet beforehand. They'll also get their first rabies vaccine depending on state-mandated vaccine schedules for puppies, as well as a second shot of the Lepto vaccine (if applicable).

Boosters Every 1-3 Years

Puppies will need a booster shot for all vaccines at age 1. Dogs need booster vaccinations for Bordetella, Lepto, Lyme, and Giardia, annually receiving their first immunization as an adult. The vaccination schedule for DHPP and rabies is every 3 years, but check your local laws and defer to your veterinarian's advice to ensure your pet stays free of disease.

How much are puppy shots?

Typically, the total cost to vaccinate a puppy ranges from $75 to $100 for core vaccinations administered in three separate doses. The rabies vaccine usually costs an additional $15 to $20. Non-essential vaccines your vet may recommend will also increase the price.

Note that puppy shots cost more or less depending on several different factors, including your location. For instance, vets in crowded urban areas tend to charge more than vets in smaller towns and rural areas.

Also keep in mind that you'll need to budget for booster shots in one- or three-year intervals to ensure your pet stays protected from disease. Fortunately, vaccines for dogs are less expensive than first-year puppy shots because boosters are administered in one dose every few years, as opposed to multiple doses every few weeks.

PRO TIP: Many pet wellness plans can help offset the cost of puppy vaccines with coverage for routine care.

Key Takeaways

• Vaccination is a great way to give your puppy immunity to infectious diseases and ensure that they’re as safe and healthy as they can be.
• All puppies need to get the core vaccines, i.e., be immunized against Parvovirus, Distemper, Hepatitis, and Rabies. Non-core vaccines include Bordetella, Lyme disease, and Canine Influenza, and should be considered based on your pet’s exposure risk — lifestyle and where you live.
• Your veterinarian will consider the risk factors and advise you on which vaccines are best for your puppy during the first vet visit.