Simplified Academic Research Consortium For High Bleeding Risk ...

Circulation Journal Online ISSN : 1347-4820 Print ISSN : 1346-9843 ISSN-L : 1346-9843

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Simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) Definition Predicts Bleeding Events in Patients With Heart Failure Yu Sato, Akiomi Yoshihisa, Ryohei Takeishi, Himika Ohara, Yukiko Sugawara, Yasuhiro Ichijo, Yu Hotsuki, Koichiro Watanabe, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Kazuhiko Nakazato, Yasuchika Takeishi 著者情報

• Yu Sato

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Akiomi Yoshihisa

  Department of Cardiovascular Medicine, Fukushima Medical University [日本] Department of Clinical Laboratory Sciences, Fukushima Medical University School of Health Science [日本]

• Ryohei Takeishi

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Himika Ohara

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Yukiko Sugawara

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Yasuhiro Ichijo

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Yu Hotsuki

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Koichiro Watanabe

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Satoshi Abe

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Tomofumi Misaka

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Takamasa Sato

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Masayoshi Oikawa

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Atsushi Kobayashi

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Kazuhiko Nakazato

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

• Yasuchika Takeishi

  Department of Cardiovascular Medicine, Fukushima Medical University [日本]

責任著者(Corresponding author)

キーワード: Gastrointestinal bleeding, Hemorrhage, Hemorrhagic stroke, High bleeding risk ジャーナル オープンアクセス HTML 早期公開 電子付録

論文ID: CJ-21-0686

DOI https://doi.org/10.1253/circj.CJ-21-0686 この記事には本公開記事があります。 Article (86-1 pp. pp. 147-155) 詳細

• Published: 2021/10/26 Received: 2021/08/02 Available on J-STAGE: - Accepted: 2021/09/12 Advance online publication: 2021/10/26 Revised: 2021/08/29

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Background:It has recently been reported that the simplified Academic Research Consortium for High Bleeding Risk (ARC-HBR) definition, which excludes 6 rare criteria, is comparable to the original ARC-HBR definition in predicting major bleeding in patients with coronary artery disease (CAD) who undergo percutaneous coronary intervention. In this study, we investigated whether the simplified ARC-HBR definition could be applied to patients with heart failure (HF) to identify those at high bleeding risk (HBR).

Methods and Results:In all, 2,437 patients hospitalized for HF were enrolled in this study. Patients were divided into 2 groups based on the simplified ARC-HBR definition: those at HBR (n=2,026; 83.1%) and those not (non-HBR group; n=411; 16.9%). The HBR group was older (72.0 vs. 61.0 years; P<0.001) and had a lower prevalence of CAD (31.1% vs. 36.5%; P=0.034) than the non-HBR group. Kaplan-Meier analysis showed that post-discharge bleeding events defined as hemorrhagic stroke or gastrointestinal bleeding were more frequent in the HBR than non-HBR group (log-rank P<0.001). The simplified ARC-HBR definition accurately predicted bleeding events (Fine-Gray model; hazard ratio 2.777, 95% confidence interval 1.464–5.270, P=0.001).

Conclusions:The simplified ARC-HBR definition predicts a high risk of bleeding events in patients with HF.

引用文献 (65) 関連文献 (0) 図 (4) 著者関連情報 電子付録 (1) 成果一覧 () 被引用文献 (1) © 2021, THE JAPANESE CIRCULATION SOCIETY This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license. https://creativecommons.org/licenses/by-nc-nd/4.0/ お気に入り & アラート

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