Skullcap: Benefits, Side Effects, And Dosage - Healthline

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Nutrition

Evidence BasedUses and Benefits of Skullcap

Medically reviewed by Kerry Boyle D.Ac., M.S., L.Ac., Dipl. Ac., CYT — Written by Jillian Kubala, MS, RD — Updated on August 13, 2025

What it is
Benefits
Downsides
Dosage
Takeaway

Skullcap is a flowering plant that has been used in traditional medicine for a long time. Supplements may provide health benefits, including improved mood, reduced inflammation, and anticancer effects. However, research continues to investigate possible side effects.

Skullcap (sometimes spelled scullcap) is the common name for Scutellaria, a genus of flowering plants in the mint family.

Practitioners in traditional Chinese and Native American medicine use various parts of skullcaps, such as their roots and leaves, to treat ailments ranging from diarrhea to chronic pain.

Today, this plant is widely available in supplement form and is meant to provide various health benefits, from boosting heart health to relieving anxiety.

This article covers everything you need to know about skullcaps, including their uses, potential health benefits, and side effects.

What is skullcap and how is it used?

The name skullcap refers to any plant in the Scutellaria family, though American and Chinese varieties are most commonly used in natural medicine.

American skullcap (Scutellaria lateriflora) is a perennial (flourishing throughout the year) herb native to North America.

The leaves of American skullcap have been used in traditional herbal medicine. They have an association with calming properties, which practitioners often use to ease anxiety or epileptic convulsions.

However, modern research is limited to in vitro studies without evidence of treating specific conditions.

Chinese skullcap (Scutellaria baicalensis) is native to several Asian countries, as well as Russia.

The dried roots of this plant have been used for centuries as a traditional Chinese medicine known as Huang Qin to treat:

diarrhea
insomnia
dysentery
high blood pressure
hemorrhaging
respiratory infections
inflammation

In Asia, Huang Qin is used in herbal remedies, such as Xiao Chai Hu Tang, also known as Sho-saiko-to (SST), a popular formulation used to treat conditions like fever, gastrointestinal issues, and liver disease.

Xiao Chai Hu Tang may need to be prescribed by a licensed practitioner of traditional Chinese herbal medicine. The National Certification Commission for Acupuncture and Oriental Medicine can help you find one in your area.

Both American and Chinese skullcaps are available as supplements that can be purchased online or in health food stores. Other varieties, such as Scutellaria barbata, are also used in alternative medicine and have been studied for their potential health benefits.

Skullcap is sold in capsules, powders, and liquid extracts. Dried parts of the plant, such as its leaves, are likewise used to brew tea.

Potential benefits of skullcap

Supplementing with skullcap may provide several benefits, though research in most of these areas is limited.

May boost mood and reduce anxiety

American skullcap has been shown to boost mood and reduce symptoms of anxiety.

A small, older 2013 study of 43 people found that those who received 1,050 mg of American skullcap daily for 2 weeks reported significant enhancements in mood compared to a placebo group.

It’s thought that American skullcap positively impacts mood and reduces anxiety by stimulating gamma-aminobutyric acid (GABA), a neurotransmitter that helps calm nerves.

Notably, this plant was used in traditional medicine practices as a sedative and treatment for conditions like insomnia and anxiety.

In fact, many anti-anxiety medications work similarly by increasing GABA activity.

Has antibacterial and antiviral effects

Scutellaria (S.) barbata, also known as barbat skullcap, is another species with medicinal properties. Studies indicate that it has powerful antiviral and antibacterial effects.

One test-tube study found that barbat skullcap could potentially help prevent COVID-19 infection by blocking key proteins the virus uses to infect cells.

Another older study sampled over 30 Chinese herbs and found that only S. barbata extract showed 100% antibacterial activity against Acinetobacter baumannii (XDRAB), a bacterium that is a leading cause of pneumonia in people who need to get hospitalized.

Furthermore, this extract showed better antibacterial effects than colistin, an antibiotic.

The same study demonstrated that S. barbata was also effective in reducing XDRAB bacterial load in the lungs of mice, compared to a control group.

Contains anti-inflammatory and anticancer compounds

Both American and Chinese skullcaps contain an array of beneficial plant compounds, including antioxidants, which have anti-inflammatory effects and protect your cells from damage caused by free radical molecules.

Oxidative stress, which results from an imbalance between free radicals and antioxidants, is linked to a number of chronic conditions, such as certain cancers and heart disease.

Notably, baicalin, a flavonoid antioxidant in both American and Chinese skullcap, has demonstrated powerful anticancer effects and may help combat oxidative stress.

For example, in test-tube studies, baicalinhas been shown to slow down tumor growth, causing cancer cells to die, and affecting important cell signals in the body. Research indicates its effectiveness against several types of cancer, including cervical, breast, stomach, bladder, prostate, and lung cancers.

However, it’s important to note that these results are preliminary, and further research is required to determine whether baicalin has similar effects in humans.

Scutellarein is another American skullcap compound that exhibits potent anticancer potential in test-tube studies.

Additionally, some test tube studies reveal that wogonin, a flavonoid compound in Chinese and American skullcap, is particularly effective in treating inflammatory conditions like psoriasis.

It’s worth noting that Chinese and American skullcaps contain many other anti-inflammatory compounds. In fact, more than 40 flavonoids have been isolated from the Chinese species alone.

Other potential benefits

Skullcap has been linked to several other benefits, including:

Anticonvulsant effects: Orally supplementing with American skullcap has been shown to have anticonvulsant effects in rodents.
Insomnia: Baicalin, a compound found in both American and Chinese skullcap, is used to treat insomnia in traditional medicine practices. However, more research is needed.
Neurodegenerative disease: Some test-tube studies suggest that American skullcap may have neuroprotective properties, potentially safeguarding against diseases like Alzheimer’s and Parkinson’s.
Heart health: In one animal study, baicalin injections significantly reduced damage linked to an induced heart attack.

Although these effects are promising, more research is needed to determine whether skullcap is an effective treatment for these conditions.

Skullcap precautions

Although supplementing with skullcap may provide health benefits, it may not be appropriate for everyone and may cause serious side effects in some instances.

For example, American and Chinese skullcap is associated with liver damage and even liver failure in some people. That said, these outcomes mainly involved supplements containing multiple herbs, not just skullcap.

Even so, people with conditions that affect liver function should avoid this plant altogether.

Chinese skullcap has also been associated with lung complications and can interact with many common medications, such as:

blood thinners
cholesterol-lowering medications
cytochrome P450 substrate drugs

Other types, including the American variety, may cause side effects.

Additionally, due to insufficient safety information, practitioners do not recommend it for use by children or pregnant or breastfeeding people.

Some supplements have been shown to contain adulterants, which can reduce their quality and effectiveness. Others may harbor ingredients not listed on the label.

As with any supplement, use caution when buying skullcap. Rely on trusted companies certified by a third party or independent laboratory.

While different forms have been used since ancient times to treat a variety of ailments, human studies on their safety and effectiveness are lacking. Always consult your doctor before taking any herbal supplement, including skullcap.

Skullcap dosage

There is no standard dosage of skullcap. It may depend on the type and form of this herb, so it’s best to check individual supplements for more information.

Teas made of skullcap, sometimes blended with other herbs like lemon balm, are also available in health food stores and online. They may not have the same effects as supplements because tea is typically less concentrated.

Tinctures containing skullcap and other potentially calming herbs, such as valerian root, are also available. The dosage for tinctures depends on concentration and ingredients.

The bottom line

Skullcap is a flowering plant that has been used in traditional medicine for a long time.

Supplementing with skullcap may provide several health benefits, such as improved mood, reduced inflammation, and anticancer effects.

However, human research on skullcap is lacking, and this supplement may cause several adverse side effects.

For this reason, it’s best to consult your doctor if you’re interested in taking any form of skullcap.

How we reviewed this article:

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

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Medically reviewed by Kerry Boyle D.Ac., M.S., L.Ac., Dipl. Ac., CYT — Written by Jillian Kubala, MS, RD — Updated on August 13, 2025

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Nutrition

Nutrition

What is skullcap and how is it used?

Potential benefits of skullcap

May boost mood and reduce anxiety

Has antibacterial and antiviral effects

Contains anti-inflammatory and anticancer compounds

Other potential benefits

Skullcap precautions

Skullcap dosage

The bottom line

How we reviewed this article:

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