Suppositories: What They Treat And How To Use Them - WebMD

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Written by Stephanie WatsonMedically Reviewed by Melinda Ratini, MS, DO on November 25, 2025
  • Types of Suppositories
  • Why Use Them
  • How to Insert Them
  • Problems You Might Have
3 min read

Medicine can get into your body in a few different ways. You can swallow a pill, drink a liquid, or get a shot. A suppository is another way to deliver a drug. It's a small, round or cone-shaped object that you put in your body, often into your bottom. Once it’s inside, it melts or dissolves and releases its medication.

Suppositories may not be the most pleasant product you’ll ever use. But they can make it easier to take medicine that you can't swallow or that your stomach or intestines wouldn't absorb well.

Types of Suppositories

Suppositories have a base made from substances like gelatin or cocoa butter that surrounds the drug. As the warmth of your body melts the outside, the drug slowly releases.

Different types of suppositories go into the rectum or vagina. Sometimes they treat the area where you put them in. Or the medicine absorbs into your blood and travels to other parts of your body.

Rectal suppositories go in your bottom. They are about an inch long and have a rounded or bullet-shaped tip. You might take them to treat:

  • Allergies
  • Anxiety
  • Constipation
  • Fever
  • Hemorrhoids
  • Motion sickness
  • Nausea
  • Pain and itching
  • Seizures
  • Mental health problems, such as schizophrenia or bipolar disorder

Vaginal suppositories are oval-shaped. You can use them for:

  • Bacterial or fungal infections
  • Vaginal dryness
  • Birth control

 

Why Use Them

You might need a suppository if:

  • The drug you’re taking would break down too quickly in your digestive tract if you took it as a pill or liquid.
  • You can’t swallow medicine.
  • You’re vomiting and can't keep a pill or liquid down.
  • The medicine tastes too bad to take by mouth.

How to Insert Them

To put in a rectal suppository:

  • Go to the bathroom first to try to empty your colon.
  • Wash your hands with soap and warm water.
  • Unwrap the suppository.
  • Rub a water-based lubricant over the tip or dip it in water. It will help you slide it in smoothly.
  • Get in a comfortable position. You can stand with one leg up on a chair or lie on your side with one leg straight and the other bent in toward your stomach.
  • Gently spread your buttocks open.
  • Carefully push the suppository, tapered end first, about 1 inch into your bottom.
  • Close your legs and sit or lie still for about 15 minutes to let it dissolve.
  • Wash your hands again with warm water and soap.

To put a suppository into your vagina:

  • Wash your hands with soap and warm water.
  • Unwrap the suppository and put it into the applicator.
  • Lie on your back with your knees bent toward your chest, or stand with your knees bent and your feet a few inches apart.
  • Gently put the applicator into your vagina as far is it will go without feeling uncomfortable.
  • Press on the plunger at the end of the applicator to push the suppository in, then remove the applicator.
  • Lie down for a few minutes to let the medicine absorb.
  • Wash your hands again with soap and warm water.

Vaginal suppositories can be messy, so you may want to wear a pad for a little while after you put one in.

 

Problems You Might Have

Suppositories are usually safe. Yet there can be some problems when you take medicine this way:

  • Some of the medicine might leak back out.
  • Sometimes your body doesn’t absorb the drug as well as if you took it by mouth.
  • The medicine can irritate the spot where you put it in.

Ask your doctor before you use a suppository if you:

  • Have an irregular heartbeat
  • Have had recent surgery on your rectum
  • Are a man who's had prostate surgery recently
  • Are a woman who’s had surgery or radiation treatment to your vaginal area

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Tag » How To Use A Vaginal Suppository