Testolone - Uses, Side Effects, And More - WebMD

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• testolone

Testolone - Uses, Side Effects, and More OTHER NAME(S): RAD 140, RAD-140, RAD140, 2-chloro-4-[[(1R,2S)-1-[ ... Show More OTHER NAME(S): RAD 140, RAD-140, RAD140, 2-chloro-4-[[(1R,2S)-1-[ ... Show More

• Overview
• Uses
• Side Effects
• Precautions
• Interactions
• Dosing
• Reviews (0)

Overview

Testolone is a type of chemical known as a selective androgen receptor modulator (SARM). It mimics the activity of testosterone in the body. People use testolone to improve athletic performance and muscle strength, for breast cancer, and for other purposes, but there is no good scientific evidence to support these uses. Testolone might also be unsafe.Testolone is not legally allowed in dietary supplements in the US, but it's still found in some products sold online. Testolone is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA).

Uses & Effectiveness

We currently have no information for Testolone overview.

Side Effects

When taken by mouth: Testolone is possibly unsafe. There have been reports of heart attack and liver injury after use.

Special Precautions and Warnings

When taken by mouth: Testolone is possibly unsafe. There have been reports of heart attack and liver injury after use. Pregnancy and breast-feeding: Testolone is possibly unsafe when taken by mouth while pregnant or breast-feeding. Avoid using. Liver disease: Testolone might harm the liver. People with liver disease or a history of liver disease should avoid testolone.

Interactions

Moderate Interaction

Be cautious with this combination

• Medications that can harm the liver (Hepatotoxic drugs) interacts with Testolone

  Testolone might harm the liver. Some medications can also harm the liver. Taking testolone along with a medication that can harm the liver might increase the risk of liver damage.

Dosing

Despite being banned in the US, testolone is still found in some dietary supplements sold online. It's also banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA). There have been reports of heart attack and liver injury after use. View References REFERENCES:

Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100.

Selective Androgen Receptor Modulators (SARMs) - A Prohibited Class of Anabolic Agents. U.S. Anti-Doping Agency, November 18, 2015. https://www.usada.org/selective-androgen-receptor-modulators-sarms-prohibited-class-anabolic-agencts/. Accessed: August 30, 2017.

Dynamic Technical Formulations, LLC. Issues a Voluntary Nationwide Recall of Tri-Ton Due to the Presence of Andarine and Ostarine. FDA Recalls, Market Withdrawals, & Safety Alerts, May 19, 2017. https://www.fda.gov/Safety/Recalls/ucm559700.htm?source=govdelivery&utm_medium=email&utm_source=govdelivery. Accessed: Sept 7, 2017.

2017-18 NCAA Banned Drugs List. National Collegiate Athletic Association (NCAA), June 5, 2017. https://www.ncaa.org/2017-18-ncaa-banned-drugs-list. Accessed: Sept 7, 2017

Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017

Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017

Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017

Yu Z, He S, Wang D, et al. Selective androgen receptor modulator RAD140 inhibits the growth of androgen/estrogen receptor-positive breast cancer models with a distinct mechanism of action. Clin Cancer Res 2017;23(24):7608-7620.

LoRusso P, Hamilton E, Ma C, et al. A first-in-human phase 1 study of a novel selective androgen receptor modulator (SARM), RAD140, in ER+/HER2- metastatic breast cancer. Clin Breast Cancer 2022;22(1):67-77.

Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409.

Padappayil RP, Chandini Arjun A, Vivar Acosta J, Ghali W, Mughal MS. Acute myocarditis from the use of selective androgen receptor modulator (SARM) RAD-140 (Testolone). Cureus. 2022;14(1):e21663.

Miller CP, Shomali M, Lyttle CR, et al. Design, synthesis, and preclinical characterization of the selective androgen receptor modulator (SARM) RAD140. ACS Med Chem Lett. 2010;2(2):124-9.

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