7 Aug 2006
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In most cells, HK phosphorylates 2-deoxyglucose into 2-deoxyglucose-6-phosphate, which then acts to competitively inhibit the production of G-6-P from glucose. Inhibition of Glucose... · Inhibition of Hexokinase (HK) · Inhibition of Isocitrate...
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All compounds tested blocked glycolysis as indicated by increased extracellular glucose and decreased lactate production and also increased apoptosis. ... Abstract · INTRODUCTION · RESULTS · DISCUSSION
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29 Jul 2019 · Glycolysis Enzyme Inhibition. Hexokinase, as noted, is inhibited by G6P. PFK and pyruvate kinase are both inhibited by the presence of ATP for ...
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One logical approach is to inhibit glycolysis and thus block the major metabolic pathway by which the respiration-deficient cancer cells generate their ATP. 3- ... Abstract · Introduction · Materials and Methods · Results Missing: inhibited | Must include: inhibited
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19 May 2021 · Inhibition of glycolysis by 2-DG is predicted to cause a compensatory increase in mitochondrial respiration to maintain ATP production.
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This makes the biochemical basis of therapeutic design and strategies to kill cancer cells by targeting pharmacological inhibition of glycolysis.
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Obligate ATP production via glycolysis also occurs in the absence of oxygen whether mitochondria are present or not. Overproduction of lactic acid by anaerobic ...
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Citrate. Citrate, the first product of the citric acid cycle, can also inhibit PFK. If citrate builds up, this is a sign that glycolysis can slow down ...
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The entry point of glucose is the formation of glucose‐6‐phosphate. Hexokinase is feedback‐inhibited by its product, so the phosphorylation of glucose is ...
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2 Oct 2020 · 1). ATP further allosterically inhibits pyruvate kinase to reduce the rate of glycolysis when energy charge is high. Therefore, under conditions ...
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abilities of cancer cells treated with DOX while glycolysis is inhibited. ... compounds were added when 70–80% confluence was achieved.
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In Candida albicans, cyanide and antimycin A inhibited K+ transport, not only with ethanol-O2 as the substrate, but also with glucose.
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Therefore, since a miniscule vanadate concentration remains it is unlikely that inhibition of glyceraldehyde-3-P dehydrogenase occurs through a transition ...
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Cells can also produce ATP through glycolysis, which takes place ... words, if glycolysis was always inhibited in the presence of O2,.
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