What Happens If People Start Drinking Mouthwash As Surrogate ...

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Abstract

Mouthwash ingestion has been observed in settings of restricted availability to alcoholic beverages such as in hospitals, prisons or military establishments. The literature offers limited evidence that ingredients of mouthwash may have health effects above the effects of ethanol. This study provides a quantitative risk assessment based on analysis of 30 mouthwash samples. All investigated brands contained alcohol, most of them menthol (93%), eucalyptol (90%), benzoic acid (87%), methyl salicylate (67%), and thymol (30%). For low risk drinking scenarios with average levels, only ethanol will exceed acceptable daily intakes (ADI). In worst case scenarios for alcohol dependent consumers ingesting 100g ethanol per day in the form of mouthwash, methyl salicylate will also exceeded the ADI by a factor of 17. The margin of exposure (MOE) for methyl salicylate, benzoates and thymol was below 100 for average scenarios, and below 10 for worst case scenarios, but ethanol is still the most toxic ingredient with MOE below 1. The occasional or even chronic ingestion of mouthwash may not cause health effects except the effects of ethanol alone. Only in extreme exposures, ingredients such as thymol or methyl salicylate could exacerbate the effects of ethanol, especially by contributing to metabolic acidosis.

Copyright © 2012 Elsevier Ltd. All rights reserved.

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MeSH terms

• Benzoic Acid / analysis Actions
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• Cyclohexanols / analysis Actions
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• Drinking Behavior* Actions
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• Ethanol / analysis Actions
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• Eucalyptol Actions
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• Humans Actions
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• Menthol / analysis Actions
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• Monoterpenes / analysis Actions
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• Mouthwashes / adverse effects* Actions
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• Mouthwashes / analysis Actions
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• Mouthwashes / chemistry* Actions
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• Risk Assessment Actions
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• Salicylates / analysis Actions
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• Thymol / analysis Actions
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• Cyclohexanols Actions
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• Monoterpenes Actions
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• Salicylates Actions
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• Menthol Actions
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• Thymol Actions
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• Ethanol Actions
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• Benzoic Acid Actions
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• methyl salicylate Actions
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• Eucalyptol Actions
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