What Is Quercetin? Benefits, Foods, Dosage, And Side Effects

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Evidence BasedQuercetin: Health Benefits, Foods to Increase Your Intake, and Supplement Safety

Medically reviewed by Adrienne Seitz, MS, RD, LDN — Written by Ryan Raman, MS, RD — Updated on July 16, 2024

Benefits
Food sources
Supplements and dosage
Safety and side effects
Bottom line

Quercetin is an antioxidant that may have health benefits, including reducing inflammation and lowering the risk of developing certain diseases. You consume it in foods like peppers, berries, and kale.

Quercetin is a pigment that belongs to a group of plant compounds called flavonoids that are present in many:

vegetables like onions, peppers, and broccoli
fruits like apples, grapes, berries, cherries, citrus, and capers
beverages like green tea, coffee, and red wine
certain grains

It’s one of the most abundant antioxidants in the diet and plays an important role in helping your body combat free radical damage, which is linked to chronic diseases.

Key terms

Antioxidants are compounds that can bind to and neutralize free radicals.

Free radicals are unstable molecules that may cause cellular damage when their levels become too high. Damage caused by free radicals has been linked to numerous chronic conditions, including cancer, heart disease, and diabetes.

In addition, its antioxidant properties may help reduce:

inflammation
allergy symptoms
blood pressure

Learn how quercetin supports your immune and overall health, the possible benefits and side effects of increasing your intake, food sources, and what dosage recommendations to stick to if you’re taking it as a dietary supplement.

two wooden bowls filled with salad — Claudia Totir/Getty Images

Health benefits of quercetin

Research has linked quercetin’s antioxidant properties to various potential health benefits.

Quercetin is the most abundant flavonoid in the diet. It’s estimated that the average person consumes 10–100 mg of it daily through various food sources.

Flavonoids like quercetin have beneficial effects because they function as antioxidants inside the body. Flavonoids have been linked to several health benefits, including reduced risks of heart disease, cancer, and degenerative brain disorders.

Here are some of its top science-based benefits.

May reduce inflammation

Free radicals may do more than simply damage your cells. High levels of free radicals may help activate genes that promote inflammation. Thus, high levels of free radicals may lead to an increased inflammatory response.

While a little inflammation is necessary to help your body heal and fight infections, persistent inflammation is linked to health problems, including certain cancers, as well as heart and kidney diseases.

Studies show that quercetin may help reduce inflammation.

In test-tube studies, quercetin reduced markers of inflammation in human cells, including the molecules tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6).

An 8-week study in 50 women with rheumatoid arthritis observed that participants who took 500 mg of quercetin experienced significantly reduced early morning stiffness, morning pain, and after-activity pain.

They also had reduced markers of inflammation, such as TNFα, compared to those who received a placebo.

While these findings are promising, more human research is needed to understand the compound’s potential anti-inflammatory properties.

May ease allergy symptoms

Quercetin’s potential anti-inflammatory properties may provide allergy symptom relief.

Test-tube and animal studies found that it may block enzymes involved in inflammation and suppress inflammation-promoting chemicals, such as histamine.

For example, one study showed that taking quercetin supplements suppressed peanut-related anaphylactic reactions in mice.

Still, it’s unclear whether the compound has the same effect on allergies in humans, so more research is needed before it can be recommended as an alternative treatment.

May have anticancer effects

Because quercetin has antioxidant properties, it may have cancer-fighting properties.

In a review of test-tube and animal studies, quercetin was found to suppress cell growth and induce cell death in prostate cancer cells.

Other test-tube and animal studies observed that the compound had similar effects in liver, lung, breast, bladder, blood, colon, ovarian, lymphoid, and adrenal cancer cells.

Though these findings are promising, human studies are needed before quercetin can be recommended as an alternative treatment for cancer.

May lower your risk of chronic brain disorders

Research suggests that quercetin’s antioxidant properties may help protect against degenerative brain disorders, such as Alzheimer’s disease and dementia.

In one study, mice with Alzheimer’s disease received quercetin injections every 2 days for 3 months.

By the end of the study, the injections had reversed several markers of Alzheimer’s, and the mice performed much better on learning tests.

In another study, a quercetin-rich diet reduced markers of Alzheimer’s disease and improved brain function in mice at the early middle stage of the condition.

However, the diet had little to no effect on animals with middle-late stage Alzheimer’s.

Coffee is a popular beverage that has been linked to a lower risk of Alzheimer’s disease.

In fact, research shows that quercetin, not caffeine, is the primary compound in coffee that’s responsible for its potential protective effects against this illness.

Though these findings are promising, more research in humans is needed.

May reduce blood pressure

High blood pressure affects 1 in 3 American adults. It raises your risk of heart disease — the leading cause of death in the United States.

Research suggests that quercetin may help reduce blood pressure levels. In test-tube studies, the compound appeared to have a relaxing effect on blood vessels.

When mice with high blood pressure were given quercetin daily for 5 weeks, their systolic and diastolic blood pressure values (the upper and lower numbers) decreased by an average of 18% and 23%, respectively.

Similarly, a review of 9 human studies in 580 people found that taking more than 500 mg of quercetin in supplement form daily reduced systolic and diastolic blood pressure by an average of 5.8 mm Hg and 2.6 mm Hg, respectively.

Although these findings are promising, more human studies are needed to determine whether the compound could be an alternative therapy for high blood pressure levels.

Other potential benefits

Here are several other potential benefits of quercetin:

May help combat aging. Test-tube and animal research suggests that quercetin may help rejuvenate or eliminate aging cells and reduce markers of aging. However, more human research is needed.
May aid exercise performance. A review of 11 human studies found that taking quercetin may slightly improve endurance exercise performance.
May aid blood sugar control. Human and animal research indicates that the compound may reduce fasting blood sugar levels and protect against complications of diabetes.

How to increase quercetin through food sources

Quercetin is found naturally in many plant-based foods, particularly in the outer layer or peel.

Good food sources include:

capers
peppers — yellow and green
onions — red and white
shallots
asparagus — cooked
cherries
tomatoes
red apples
red grapes
broccoli
kale
red leaf lettuce
berries — all types, such as cranberries, blueberries, and raspberries
tea — green and black

Note that the amount of quercetin in foods may depend on the conditions in which the food was grown.

For example, in one study, organic tomatoes appear to have up to 79% more quercetin than conventionally grown ones.

However, other studies point out differences between the quercetin content in various species of tomatoes regardless of the farming method. There was no difference in bell peppers, conventionally or organically grown.

»Learn more:What Is Organic Food, and Is It Better Than Non-Organic Food?

Quercetin supplement dosage and how to take it

You can purchase quercetin as a dietary supplement in powder and capsule form in most health food stores and online.

People take this supplement for several reasons, including:

supporting immune health
reducing inflammation
relieving allergies
aiding exercise performance
maintaining general health

It’s best to talk with a doctor before adding any supplement to your diet, as they can potentially interact with medications and other supplements you may be taking.

Typical dosages range from 500–1,000 mg per day.

On its own, quercetin has a low bioavailability, which means your body absorbs it poorly.

That’s why quercetin supplements often include other compounds, such as vitamin C or digestive enzymes like bromelain, which may increase absorption.

Additionally, some research indicates that quercetin has a greater beneficial effect when combined with other flavonoid supplements, such as resveratrol, genistein, and catechins.

»Learn more:How to Choose High Quality Vitamins and Supplements

Safety, side effects, and when to talk with a doctor

Quercetin is found in many fruits and vegetables and is safe to consume.

As a supplement, it appears to be generally safe with little to no side effects. However, it’s always best to talk with a doctor before taking a dietary supplement.

In some instances, taking more than 1,000 mg of quercetin per day may cause mild symptoms like headaches, stomach aches, or tingling sensations.

When consumed in food, quercetin is safe for people who are pregnant or breastfeeding.

However, studies on the safety of quercetin supplements for people who are pregnant and breastfeeding are lacking, so you should avoid taking quercetin if you’re pregnant or nursing.

As with any supplement, consult with a healthcare professional familiar with your medical history before taking quercetin. It can interact with some medications, including antibiotics and blood pressure medications.

The bottom line

Quercetin is the most abundant dietary flavonoid.

It’s been linked to improved exercise performance and reduced inflammation, blood pressure, and blood sugar levels. Plus, it may have brain-protective, anti-allergy, and anticancer properties.

Though its benefits seem promising, more human research is needed.

How we reviewed this article:

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

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Medically reviewed by Adrienne Seitz, MS, RD, LDN — Written by Ryan Raman, MS, RD — Updated on July 16, 2024

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Key terms

Health benefits of quercetin

May reduce inflammation

May ease allergy symptoms

May have anticancer effects

May lower your risk of chronic brain disorders

May reduce blood pressure

Other potential benefits

How to increase quercetin through food sources

Quercetin supplement dosage and how to take it

Safety, side effects, and when to talk with a doctor

The bottom line

How we reviewed this article:

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