When Can You Drink Alcohol After Taking Flexeril? - HelloPharmacist

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When Can You Drink Alcohol After Taking Flexeril?

In our latest question and answer, the pharmacist discusses when it is safe to drink alcohol after taking the muscle relaxant Flexeril (cyclobenzaprine).

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Question

How long after taking cyclobenzaprine can someone consume alcohol?

Asked by Bubby On Aug 23, 2022

Answered by Dr. Brian Staiger, PharmD Medical Content Reviewed By HelloPharmacist Staff

Pharmacist's Answer Published Aug 23, 2022 Last updated Dec 22, 2025

Key points

• Flexeril (cyclobenzaprine) lasts quite a while in your system, longer than 24 hours.
• It is generally recommended to avoid alcohol while taking cyclobenzaprine.
• If you do decide to drink, I would recommend waiting at least 24 hours and drinking less than your might normally.

Answer

Thanks for your question!

Cyclobenzaprine actually lasts quite a long time in your system. The reported half-life of the drug, the amount of time that it takes for your body to metabolize half of the medication and remove it from your body, ranges between 8-37 hours in most adults.

Now, the half-life is It’s dependent on several factors such as your genetics, age, and liver function. The elderly and folks with impaired liver function tend to metabolize it slower. If we assume that you metabolize cyclobenzaprine quickly, even 24 hours after a single 10mg dose, at least 1.25mg of cyclobenzaprine would still be in your system.

Per the labeling information:

“Cyclobenzaprine, especially when used with alcohol or other CNS depressants, may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle.”

Since it does last a while in your system, I would recommend waiting about 24 hours after your last dose of cyclobenzaprine before you have a drink. At the very least, you should wait around 8 hours after taking a dose as that is the timeframe where the drug has the most effect.

Now, drinking while on cyclobenzaprine is discouraged, but not contraindicated. If you do decide to drink, remember that alcohol and cyclobenzaprine have a similar effect on your central nervous system. Since you might still have cyclobenzaprine in your system, you will feel the effects of the alcohol after a fewer number of drinks and more intensely than drinking with no cyclobenzaprine in your system.

Final Words

I hope I was able to help. Feel free to write us back in the future.

References

• Cyclobenzaprine Prescribing Information, AccessFDA

• Dr. Brian Staiger, PharmD
• 3 years ago
• 11717 views

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About the Pharmacist

Dr. Brian Staiger, PharmD

Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. From retail, clinical, program development, and administrative responsibilities, he's your knowledgeable and go-to source for all your pharmacy and medication-related questions! Dr. Brian Staiger also has herbalist training and educational certificates in the field of medical ethnobotany. Feel free to send him an email at [email protected]! You can also connect with Dr. Brian Staiger on LinkedIn.

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