ZYRTEC-D® Allergy Medicine Plus Decongestant

Skip to main contentZyrtec-DZYRTEC-D®: Allergy relief & nasal decongestant front pack imageZYRTEC-D®: Allergy relief & nasal decongestant in one & starts to work on congestion in 30 minutes.FAST relief of symptoms that may be triggered by 200+ allergens including pollen, pet dander, dustGreen background and text "24-hour relief of" graphics: runny nose, sneezing, itchy eyes/nose/throatZYRTEC®-D starts to work on congestion in 30 minutesGraphic of HSA/FSA eligibility claim, no prescription needed*ZYRTEC-D®: Allergy relief & nasal decongestant back pack imageZYRTEC-D® Allergy + Congestion Relief Tablets with Decongestant and Cetirizine HCl

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Product Overview

The proven allergy relief of ZYRTEC® plus a decongestant to provide powerful allergy congestion relief. ZYRTEC-D® Allergy Relief and Nasal Decongestant Tablets contain 5 mg cetirizine HCl antihistamine and 120 mg pseudoephedrine decongestant for relief from nasal congestion, sinus pressure, and allergy symptoms caused by pollen, dust, pet dander, mold, and other airborne allergens. These 2-in-1 allergy medicine tablets get to work in as little as 30 minutes, for fast allergy congestion relief that lasts for 12 hours.

From the #1 doctor and allergist recommended OTC allergy brand when it comes to oral antihistamines, this extended-release 12 hour allergy medicine plus decongestant is suitable for those 12 years of age and older.

There are current regulations that apply to the sale of pseudoephedrine products, so ZYRTEC-D® can only be sold in stores behind the pharmacist counter. It is not available for online purchase. No prescription needed.*

Click here to redeem an exclusive offer on your ZYRTEC-D® purchase.

*In most states.

  • Allergy relief & nasal decongestant tablets

  • 5 mg cetirizine HCl & 120 mg pseudoephedrine

  • For sinus pressure & nasal congestion relief

This website contains current product information and may differ from the information on the product packaging you may have. If you have any questions, please contact the Consumer Care Center (CCC) at 1-800-343-7805

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  1. Overview
  2. Benefits
  3. Used For
  4. Directions
  5. Warnings
  6. ingredients
  7. Related Products
  8. FAQS
  9. Reviews

Caring for Your Allergies

Learn MoreZyrtec Starts working in 30 minutes Icon

Starts working in 30 minutes

Zyrtec Allergy relief + nasal decongestant Icon

Allergy relief + nasal decongestant

Zyrtec 12-hour relief Icon

12-hour allergy relief

Caring for the Planet

Learn MoreZyrtec 100% plastic free Icon

Outer packaging 100% plastic-free

Zyrtec Outer packaging made of 100% recyclable paper Icon

Outer packaging made of 100% recyclable paper

Ingredients Spotlight

Active Ingredient

Cetirizine HCl 5 mg (in each extended release tablet)

Pseudoephedrine HCl 120 mg (in each extended release tablet)

When you have an allergic reaction, your immune system releases chemicals called histamines to fight the allergen, which leads to various allergy symptoms. Cetirizine helps relieve these allergy symptoms by blocking the effects of histamines, reducing the severity of your symptoms.

SEE ALL ZYRTEC® INGREDIENTSSEE INGREDIENT DESCRIPTIONS

Product Details

Used For

This 2-in-1 allergy medicine combines the proven relief of ZYRTEC® with a nasal decongestant to help provide powerful relief from the following 8 allergy symptoms:

 Nasal congestion 

 Sneezing 

 Itchy Eyes 

 Itchy Nose 

 Sinus Congestion & Pressure 

 Runny Nose 

 Watery Eyes 

 Itchy Throat  

Directions

Age/Condition

Directions

 Adults and children 12 years and over

Take 1 tablet every 12 hours; do not take more than 2 tablets in 24 hours.

Adults 65 years and over

Ask a doctor.

 Children under 12 years of age

Ask a doctor.

 Consumers with liver or kidney disease

Ask a doctor.

Do not break or chew tablet; swallow tablet whole.

Other information

Store between 20° to 25°C (68° to 77°F)

Do not use if blister unit is torn or broken

Questions? call 1-800-343-7805 (toll-free) or 215-273-8755 (collect)

Warnings

 Do not use: 

  • if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing hydroxyzine

  • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product

 Ask a doctor before use if you have: 

  • heart disease

  • thyroid disease

  • diabetes

  • glaucoma

  • high blood pressure

  • trouble urinating due to an enlarged prostate gland

  • liver or kidney disease. Your doctor should determine if you need a different dose.

 Ask a doctor or pharmacist before use if you are  taking tranquilizers or sedatives.

 When using this product: 

  •  do not use more than directed 

  • drowsiness may occur

  • avoid alcoholic drinks

  • alcohol, sedatives and tranquilizers may increase drowsiness

  • be careful when driving a motor vehicle or operating machinery

 Stop use and ask a doctor if: 

  • an allergic reaction to this product occurs. Seek medical help right away

  • you get nervous, dizzy, or sleepless

  • symptoms do not improve within 7 days or are accompanied by fever

 If pregnant or breast-feeding: 

  • if breast-feeding: not recommended

  • if pregnant: ask a health professional before use

 Keep out of reach of children.  In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222)

Zyrtec AllergyCast® Personalized Allergy Quiz

Your Personalized Pollen Prediction

We’re here to help! Answer a few quick questions and we will give you a personalized allergy symptom prediction.

Take assessment

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Frequently Asked Questions

ALL FAQS

How is ZYRTEC-D® different from ZYRTEC®?

ZYRTEC-D® contains pseudoephedrine, which relieves nasal congestion. So it relieves all the same symptoms as ZYRTEC®, plus it also has a powerful decongestant. For more, see: “What symptoms does ZYRTEC® relieve?”

How does ZYRTEC-D® work on sinus pressure and congestion?

ZYRTEC-D® contains a nasal decongestant that narrows the blood vessels in the nose and sinus region, which shrinks the tissue in that area to allow air and mucus to flow normally.

Why is ZYRTEC-D® located behind the pharmacy counter?

Pseudoephedrine, an active ingredient in some cold, allergy, and sinus products, can be chemically processed into methamphetamine (commonly known as meth). The illegal use of meth had increased, prompting Congress to pass the Combat Methamphetamine Epidemic Act of 2006 (CEMA). The objective of the law is to eliminate the use of pseudoephedrine in the illegal production of meth. By law, products containing pseudoephedrine must now be sold behind the counter and through online retailers who must meet certain requirements.

Note that products containing pseudoephedrine remain available without a prescription in most states.

Questions About Packaging Refresh

Why does the product look different?

We have developed new outer packaging to support Kenvue’s commitment to innovation and sustainability through their Healthy Lives Mission. The 100% paper carton is recyclable and features a modern, flat-front design with improved readability.

Will the product work differently?

No, the product contains the same ingredients that helps relieve kids’ indoor and outdoor allergy symptoms such as runny nose, sneezing, and itchy nose and throat for a full 24 hours.

Will the product’s dosage or quantity change with the new packaging?

No, the formula has not changed, and the dosage and quantity has not changed.

Reviews

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