14106 - Gene ResultFoxh1 Forkhead Box H1 [ (house Mouse)] - NCBI
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Go to the top of the page Help Official Symbol Foxh1provided by MGI Official Full Name forkhead box H1provided by MGI Primary source MGI:MGI:1347465 See related Ensembl:ENSMUSG00000033837 AllianceGenome:MGI:1347465 Gene type protein coding RefSeq status VALIDATED Organism Mus musculus Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus Also known as Fast1; Fast2; fast-1; fast-2 Summary Enables DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including heart morphogenesis; regulation of transcription by RNA polymerase II; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within axial mesoderm development; regionalization; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of activin responsive factor complex. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo mesoderm; lung; and ovary. Used to study agnathia-otocephaly complex and visceral heterotaxy. Orthologous to human FOXH1 (forkhead box H1). [provided by Alliance of Genome Resources, Jul 2025] Expression Biased expression in cortex adult (RPKM 16.4), frontal lobe adult (RPKM 12.1) and 5 other tissues See more Orthologs human all NEW Try the new Gene table Try the new Transcript tableGenomic context
Go to the top of the page Help See Foxh1 in Genome Data Viewer Location: 15 D3; 15 36.24 cM Exon count: 3| Annotation release | Status | Assembly | Chr | Location |
|---|---|---|---|---|
| RS_2024_02 | current | GRCm39 (GCF_000001635.27) | 15 | NC_000081.7 (76552029..76554286, complement) |
| 108.20200622 | previous assembly | GRCm38.p6 (GCF_000001635.26) | 15 | NC_000081.6 (76667829..76671614, complement) |
Chromosome 15 - NC_000081.7
Genomic regions, transcripts, and products
Go to the top of the page Help Go to reference sequence detailsGenomic Sequence: NC_000081.7 Chromosome 15 Reference GRCm39 C57BL/6J NC_000081.6 Chromosome 15 Reference GRCm38.p6 C57BL/6J
Go to nucleotide: Graphics FASTA GenBank
Expression
Go to the top of the page Help See details Mouse ENCODE transcriptome data- Project title: Mouse ENCODE transcriptome data
- Description: RNA profiling data sets generated by the Mouse ENCODE project.
- BioProject: PRJNA66167
- Publication: PMID 25409824
- Analysis date: n/a
Bibliography
Go to the top of the pageHelpRelated articles in PubMed
- Expression and distribution of forkhead activin signal transducer 2 (FAST2) during follicle development in mouse ovaries and pre-implantation embryos. Wang G, et al. Acta Histochem, 2016 Jul. PMID 27432806
- A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1. Loizou E, et al. Cancer Discov, 2019 Jul. PMID 31068365, Free PMC Article
- Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Saijoh Y, et al. Mol Cell, 2000 Jan. PMID 10678167
- The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Takaoka K, et al. Dev Cell, 2006 Apr. PMID 16580991
- A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Weisberg E, et al. Mech Dev, 1998 Dec. PMID 10349617
See all (52) citations in PubMed
GeneRIFs: Gene References Into Functions
What's a GeneRIF?- FOXH1 was identified as a critical mediator of mutant p53 function that binds to and regulates stem cell-associated genes and transcriptional programs in the context of mouse model of acute myeloid leukemia. Title: A Gain-of-Function p53-Mutant Oncogene Promotes Cell Fate Plasticity and Myeloid Leukemia through the Pluripotency Factor FOXH1.
- that FAST2 is expressed in a cell-specific manner during ovarian follicle development Title: Expression and distribution of forkhead activin signal transducer 2 (FAST2) during follicle development in mouse ovaries and pre-implantation embryos.
- The finding that Foxh1-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions. Title: Disrupting Foxh1-Groucho interaction reveals robustness of nodal-based embryonic patterning.
- Formation of midgut and hindgut definitive endoderm is unaffected by loss of Foxh1 or Foxa2. Title: Foxh1 and Foxa2 are not required for formation of the midgut and hindgut definitive endoderm.
- Foxh1 initiates a transcriptional regulatory network within the developing anterior neuroectoderm. Title: Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development.
- As goosecoid is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation Title: Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
- A conserved intronic enhancer (ASE), containing binding sites for the fork head transcription factor Foxh1, modulates dynamic patterns of Nodal expression during early mouse development. Title: The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.
- Foxh1 and Nkx2-5 functionally interact and are essential for development of the anterior heart field and its derivatives Title: Foxh1 is essential for development of the anterior heart field.
Variation
Go to the top of the page HelpAlleles
Alleles of this type are documented at Mouse Genome Informatics (MGI)- Chemically induced (ENU) (1)
- Endonuclease-mediated (1)
- Targeted (6) 1 citation
Pathways from PubChem
Go to the top of the pageInteractions
Go to the top of the page Help| Products | Interactant | Other Gene | Complex | Source | Pubs | Description |
|---|
General gene information
Go to the top of the page HelpMarkers
- PMC313795P1 (e-PCR)
- UniSTS:272926
- Foxh1 (e-PCR), detects polymorphism
- UniSTS:143136
- NoName (e-PCR)
- UniSTS:491228
Homology
- NCBI Orthologs Orthologs from OrthoDB
Gene Ontology Provided by MGI
| Function | Evidence Code | Pubs |
|---|---|---|
| enables DNA binding | IDA Inferred from Direct Assaymore info | PubMed |
| contributes_to DNA binding | IEA Inferred from Electronic Annotationmore info | |
| enables DNA binding | IEA Inferred from Electronic Annotationmore info | |
| contributes_to DNA binding | ISO Inferred from Sequence Orthologymore info | |
| enables DNA-binding transcription activator activity, RNA polymerase II-specific | IBA Inferred from Biological aspect of Ancestormore info | |
| enables DNA-binding transcription activator activity, RNA polymerase II-specific | IDA Inferred from Direct Assaymore info | PubMed |
| enables DNA-binding transcription activator activity, RNA polymerase II-specific | IMP Inferred from Mutant Phenotypemore info | PubMed |
| enables DNA-binding transcription factor activity | IDA Inferred from Direct Assaymore info | PubMed |
| contributes_to DNA-binding transcription factor activity | IEA Inferred from Electronic Annotationmore info | |
| enables DNA-binding transcription factor activity | IEA Inferred from Electronic Annotationmore info | |
| contributes_to DNA-binding transcription factor activity | ISO Inferred from Sequence Orthologymore info | |
| enables DNA-binding transcription factor binding | IEA Inferred from Electronic Annotationmore info | |
| enables DNA-binding transcription factor binding | ISO Inferred from Sequence Orthologymore info | |
| enables R-SMAD binding | IDA Inferred from Direct Assaymore info | PubMed |
| enables R-SMAD binding | IEA Inferred from Electronic Annotationmore info | |
| enables R-SMAD binding | ISO Inferred from Sequence Orthologymore info | |
| enables SMAD binding | IEA Inferred from Electronic Annotationmore info | |
| enables SMAD binding | IPI Inferred from Physical Interactionmore info | PubMed |
| enables SMAD binding | ISO Inferred from Sequence Orthologymore info | |
| enables bHLH transcription factor binding | IEA Inferred from Electronic Annotationmore info | |
| enables bHLH transcription factor binding | ISO Inferred from Sequence Orthologymore info | |
| enables co-SMAD binding | IEA Inferred from Electronic Annotationmore info | |
| enables co-SMAD binding | ISO Inferred from Sequence Orthologymore info | |
| enables nuclear androgen receptor binding | IEA Inferred from Electronic Annotationmore info | |
| enables nuclear androgen receptor binding | ISO Inferred from Sequence Orthologymore info | |
| enables protein binding | IPI Inferred from Physical Interactionmore info | PubMed |
| enables protein domain specific binding | IEA Inferred from Electronic Annotationmore info | |
| enables protein domain specific binding | ISO Inferred from Sequence Orthologymore info | |
| enables sequence-specific DNA binding | IDA Inferred from Direct Assaymore info | PubMed |
| enables sequence-specific DNA binding | IEA Inferred from Electronic Annotationmore info | |
| enables sequence-specific DNA binding | ISO Inferred from Sequence Orthologymore info | |
| enables transcription cis-regulatory region binding | IBA Inferred from Biological aspect of Ancestormore info | |
| enables transcription cis-regulatory region binding | IDA Inferred from Direct Assaymore info | PubMed |
| enables transcription corepressor activity | IEA Inferred from Electronic Annotationmore info | |
| enables transcription corepressor activity | ISO Inferred from Sequence Orthologymore info |
| Process | Evidence Code | Pubs |
|---|---|---|
| acts_upstream_of_or_within anterior/posterior pattern specification | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in aorta morphogenesis | IMP Inferred from Mutant Phenotypemore info | PubMed |
| acts_upstream_of_or_within axial mesoderm development | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in cardiac right ventricle morphogenesis | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in cellular response to cytokine stimulus | IEA Inferred from Electronic Annotationmore info | |
| involved_in cellular response to cytokine stimulus | ISO Inferred from Sequence Orthologymore info | |
| involved_in cellular response to cytokine stimulus | ISS Inferred from Sequence or Structural Similaritymore info | |
| acts_upstream_of_or_within determination of left/right symmetry | IMP Inferred from Mutant Phenotypemore info | PubMed |
| acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in heart looping | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in hepatocyte differentiation | IEA Inferred from Electronic Annotationmore info | |
| involved_in negative regulation of androgen receptor signaling pathway | IEA Inferred from Electronic Annotationmore info | |
| involved_in negative regulation of androgen receptor signaling pathway | ISO Inferred from Sequence Orthologymore info | |
| acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II | IGI Inferred from Genetic Interactionmore info | PubMed |
| involved_in negative regulation of transcription by RNA polymerase II | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in outflow tract morphogenesis | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in positive regulation of DNA-templated transcription | IDA Inferred from Direct Assaymore info | PubMed |
| involved_in positive regulation of DNA-templated transcription | IEA Inferred from Electronic Annotationmore info | |
| involved_in positive regulation of DNA-templated transcription | ISO Inferred from Sequence Orthologymore info | |
| involved_in positive regulation of transcription by RNA polymerase II | IBA Inferred from Biological aspect of Ancestormore info | |
| involved_in positive regulation of transcription by RNA polymerase II | IDA Inferred from Direct Assaymore info | PubMed |
| involved_in positive regulation of transcription by RNA polymerase II | IEA Inferred from Electronic Annotationmore info | |
| involved_in positive regulation of transcription by RNA polymerase II | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in positive regulation of transcription by RNA polymerase II | ISO Inferred from Sequence Orthologymore info | |
| involved_in regulation of DNA-templated transcription | IEA Inferred from Electronic Annotationmore info | |
| acts_upstream_of_or_within regulation of transcription by RNA polymerase II | IDA Inferred from Direct Assaymore info | PubMed |
| involved_in regulation of transcription by RNA polymerase II | IEA Inferred from Electronic Annotationmore info | |
| involved_in secondary heart field specification | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in transforming growth factor beta receptor signaling pathway | IBA Inferred from Biological aspect of Ancestormore info | |
| involved_in transforming growth factor beta receptor signaling pathway | IDA Inferred from Direct Assaymore info | PubMed |
| involved_in transforming growth factor beta receptor signaling pathway | IMP Inferred from Mutant Phenotypemore info | PubMed |
| involved_in ventricular trabecula myocardium morphogenesis | IMP Inferred from Mutant Phenotypemore info | PubMed |
| Component | Evidence Code | Pubs |
|---|---|---|
| part_of activin responsive factor complex | IBA Inferred from Biological aspect of Ancestormore info | |
| part_of activin responsive factor complex | IDA Inferred from Direct Assaymore info | PubMed |
| part_of activin responsive factor complex | IEA Inferred from Electronic Annotationmore info | |
| part_of activin responsive factor complex | ISO Inferred from Sequence Orthologymore info | |
| located_in chromatin | IEA Inferred from Electronic Annotationmore info | |
| located_in chromatin | ISO Inferred from Sequence Orthologymore info | |
| located_in nucleoplasm | TAS Traceable Author Statementmore info | |
| located_in nucleus | IDA Inferred from Direct Assaymore info | PubMed |
| located_in nucleus | IEA Inferred from Electronic Annotationmore info | |
| located_in nucleus | ISO Inferred from Sequence Orthologymore info | |
| part_of transcription regulator complex | IDA Inferred from Direct Assaymore info | PubMed |
| part_of transcription regulator complex | IEA Inferred from Electronic Annotationmore info | |
| part_of transcription regulator complex | ISO Inferred from Sequence Orthologymore info |
General protein information
Go to the top of the page Help Preferred Names forkhead box protein H1 Names FAST1 transcription factor forkhead activin signal transducer 1 forkhead activin signal transducer 2NCBI Reference Sequences (RefSeq)
Go to the top of the page HelpNEW Try the new Transcript table
RefSeqs maintained independently of Annotated Genomes
These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_007989.4 → NP_032015.1 forkhead box protein H1
See identical proteins and their annotated locations for NP_032015.1
Status: VALIDATED
Source sequence(s) AC156550, BC119156 Consensus CDS CCDS27584.1 UniProtKB/Swiss-Prot O88621, Q9QZL5, Q9R241 UniProtKB/TrEMBL Q0VEP8 Related ENSMUSP00000036591.5, ENSMUST00000037824.6 Conserved Domains (1) summary cd00059Location:64 → 142 FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02
The following sections contain reference sequences that belong to a specific genome build. Explain
Reference GRCm39 C57BL/6J
Genomic
-
NC_000081.7 Reference GRCm39 C57BL/6J
Range 76552029..76554286 complement Download GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_006520436.5 → XP_006520499.1 forkhead box protein H1 isoform X1
See identical proteins and their annotated locations for XP_006520499.1
UniProtKB/Swiss-Prot O88621 Conserved Domains (1) summary cd00059Location:64 → 138 FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
Related sequences
Go to the top of the page Help| Nucleotide | Protein | Strain | |
|---|---|---|---|
| Heading | Accession and Version | ||
| Protein Accession | Links | |
|---|---|---|
| GenPept Link | UniProtKB Link | |
| O88621.1 | GenPept | UniProtKB/Swiss-Prot:O88621 |
Additional links
Go to the top of the pageHelpGene LinkOut
The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.
Chemical Information- Interologous Interaction Database
- Interologous Interaction Database
- MilliporeSigma
- Foxh1 products
- Bgee database
- Foxh1 gene expression
- BioGPS
- BioGPS
- BioGRID Open Repository of CRISPR Screens (ORCS)
- BioGRID CRISPR Screen Phenotypes (4 hits/85 screens)
- CTD: Comparative Toxicogenomics Database
- CTD: Comparative Toxicogenomics Database - FOXH1
- Eukaryotic Promoter Database
- Foxh1_1
- GlyGen glycoinformatics resource
- GlyGen glycoinformatics resource
- Ingenuity Pathways Analysis
- Ingenuity Pathways Analysis
- InnateDB
- InnateDB
- Kyoto Encyclopedia of Genes and Genomes
- Kyoto Encyclopedia of Genes and Genomes
- OMA Browser: Orthologous MAtrix
- OMA Browser: Orthologous MAtrix
- OrthoDB catalog of orthologs
- Orthologs
- PhosphoSitePlus
- PhosphoSitePlus® - comprehensive post-translational modification resource
- Addgene Non-profit plasmid repository
- Get Plasmids - Addgene
- ExactAntigen/Labome
- reagents
- GenScript latest version of gene cDNA ORF Clone
- GenScript latest version of gene cDNA ORF Clone
- GeneCopoeia Inc.
- Order full-length ORF clone
- Order shRNA clones
- Order miRNA target clones
- OriGene Technologies
- Order GeneID 14106 cDNA Clone|Lysate|Protein|Antibody|RNAi
- GeneMANIA
- GeneMANIA
Supplemental Content
Table of contents
- Summary
- Genomic context
- Genomic regions, transcripts, and products
- Expression
- Bibliography
- Variation
- Pathways from PubChem
- Interactions
- General gene information Markers, Homology, Gene Ontology
- General protein information
- NCBI Reference Sequences (RefSeq)
- Related sequences
- Additional links
Genome Browsers
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Related information
- Order cDNA clone Order cDNA clone
- BioAssay by Target (List) BioAssays related to the gene by protein target or RNAi target
- BioAssay, by Gene target PubChem BioAssays done on the Gene target
- BioAssays, RNAi Target, Tested BioAssays that contain the gene as the target of a RNAi reagent
- BioProjects BioProjects related to a gene
- Books Books
- CCDS Link to CCDS
- Conserved Domains Related CDD
- Full text in PMC PMC links
- Full text in PMC_nucleotide Full text in PubMedCentral identified from shared sequence links
- Functional Class Functional class of the sequence domain architecture
- Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side
- Genome Related Genome
- GEO Profiles Related GEO
- HomoloGene Related HomoloGene
- Nucleotide Link to related Nucleotide entry
- Protein Link to related protein entry
- PubChem Compound PubChem Compounds
- PubChem Substance PubChem Substances
- PubMed Link to related PubMed entry
- PubMed (GeneRIF) Link to related PubMed article from GeneRIFs
- PubMed(nucleotide/PMC) Citations in PubMed identified from shared sequence and PMC links.
- RefSeq Proteins Link to Protein RefSeqs
- RefSeq RNAs Link to Nucleotide RefSeq RNAs
- Taxonomy Link to related taxonomy entry
Links to other resources
- MGI
- Ensembl
- AllianceGenome
- Gene Expression Database (GXD) at MGI
- UCSC
- KEGG
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