18505 Anti-Human C-MPL-P (M617) Rabbit IgG Affinity Purify

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#18505 Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify

Product Search #18505 Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify

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Intended Use： Research reagents Application： WB, IP Package Size1： 100 μg Package Size2： 25 μg

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Note on Application Abbreviations WB:Western BlottingIP:Immunoprecipitation

※ The product indicated as "Research reagents" in the column Intended Use cannot be used 　 for diagnostic nor any medical purpose. ※ The datasheet listed on this page is sample only. Please refer to the datasheet 　 enclosed in the product purchased before use.

Product Overview

Product Code	18505
Product Name	Anti-Human c-MPL-P (M617) Rabbit IgG Affinity Purify
Intended Use	Research reagents
Application	WB, IP
Species	Human
Immunizing antigen	Synthetic peptide of the C terminal part of Human c-MPL-P
Purification Method	Purified with antigen peptide
Specificity	Reacts to UT-7/TPO
Package Form	Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Storage Condition	2 - 8℃
Poisonous and Deleterious Substances	Applicable
Cartagena	Not Applicable
Package Size 1	100 μg
Package Size 2	25 μg
Remarks1	The commercial use of products without our permission is prohibited. Please make sure to contact us and obtain permission.

Product Description

The c-mpl proto oncogene was first identified as the cellular homolog of the viral oncogene v-mpl in the myeloproliferative leukemia virus (MPLV). However, based on homology with a member of the cytokine receptor superfamily, the c-mpl gene was predicted to encode a receptor for some cytokine. An antisense oligomer against c-mpl selectively inhibited megakaryocytic colony formation. Moreover, c-mpl-deficient mice had selectively dramatic decrease in the number of circulating platelets and megakaryocytes in the spleen and bone marrow. Collectively, these observations suggested that the c-Mpl ligand is identical to thrombopoietin (TPO). Several groups have purified TPO as the c-Mpl ligand. In fact, in vitro and in vivo studies have shown that recombinant TPO alone can support the proliferation and differentiation of megakaryocyte progenitor cells and maturation of megakaryocyte. There are two types of alternatively spliced isoforms of c-mpl, c-mpl-P (wild type) and c-mpl-K (truncated).