2 H2O2 => O2 + 2 H2O - Reactome Pathway Database

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2 H2O2 => O2 + 2 H2O

Stable Identifier R-HSA-76031 Type Reaction [transition] Species Homo sapiens Compartment peroxisomal matrix ReviewStatus 5/5 Locations in the PathwayBrowser Expand all Cellular responses to stimuli (Homo sapiens)
    • Cellular responses to stress (Homo sapiens)
      • Cellular response to chemical stress (Homo sapiens)
        • Detoxification of Reactive Oxygen Species (Homo sapiens)
          • 2 H2O2 => O2 + 2 H2O (Homo sapiens)
General SBML | BioPAX Level 2 Level 3 | PDF SVG | PNG Low Medium High | PPTX | SBGN 2 H2O2 = O2 + 2 H2O Click the image above or here to open this reaction in the Pathway Browser The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout Hydrogen peroxide is generated in the course of peroxisomal fatty acid oxidation and purine catabolism, and is rapidly converted to water and molecular oxygen by the enzyme catalase. This enzyme is widely distributed in the body, but is especially abundant in liver, kidney, and red blood cells. Literature References
PubMed ID Title Journal Year
10656833 Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.

Putnam, CD, Arvai, AS, Bourne, Y, Tainer, JA

J Mol Biol 2000
1999334 Acatalasemia.

Ogata, M

Hum Genet 1991
Participants Input
  • x 2 H2O2 [peroxisomal matrix]
Output
  • x 2 H2O [peroxisomal matrix]
  • O2 [peroxisomal matrix]
Participates as an event of
  • Detoxification of Reactive Oxygen Species (Homo sapiens)
Catalyst Activity

catalase activity of CAT tetramer [peroxisomal matrix]

Physical Entity CAT tetramer [peroxisomal matrix] (Homo sapiens) Activity catalase activity (GO:0004096) Orthologous Events 2 H2O2 => O2 + 2 H2O (Bos taurus) 2 H2O2 => O2 + 2 H2O (Caenorhabditis elegans) 2 H2O2 => O2 + 2 H2O (Canis familiaris) 2 H2O2 => O2 + 2 H2O (Danio rerio) 2 H2O2 => O2 + 2 H2O (Dictyostelium discoideum) 2 H2O2 => O2 + 2 H2O (Drosophila melanogaster) 2 H2O2 => O2 + 2 H2O (Gallus gallus) 2 H2O2 => O2 + 2 H2O (Mus musculus) 2 H2O2 => O2 + 2 H2O (Rattus norvegicus) 2 H2O2 => O2 + 2 H2O (Saccharomyces cerevisiae) 2 H2O2 => O2 + 2 H2O (Schizosaccharomyces pombe) 2 H2O2 => O2 + 2 H2O (Sus scrofa) 2 H2O2 => O2 + 2 H2O (Xenopus tropicalis) Cross References RHEA 20310 Authored D'Eustachio, P (2003-09-15) Created D'Eustachio, P (2003-09-15)
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