2022 ICD-10-CM Diagnosis Code C22.9: Malignant Neoplasm Of ...

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2025

  1. ICD-10-CM Codes
    2. ›
  2. C00-D49
    3. ›
  3. C15-C26
    4. ›
  4. C22-
    5. ›
  5. 2025 ICD-10-CM Diagnosis Code C22.9
2025 ICD-10-CM Diagnosis Code C22.9

Malignant neoplasm of liver, not specified as primary or secondary

    2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
  • C22.9 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • Short description: Malig neoplasm of liver, not specified as primary or sec
  • The 2025 edition of ICD-10-CM C22.9 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of C22.9 - other international versions of ICD-10 C22.9 may differ.
The following code(s) above C22.9 contain annotation back-referencesAnnotation Back-ReferencesIn this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C22.9:
  • C00-D49 2025 ICD-10-CM Range C00-D49

    NeoplasmsNote
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms

  • C15-C26 2025 ICD-10-CM Range C15-C26

    Malignant neoplasms of digestive organsType 1 Excludes
    • Kaposi's sarcoma of gastrointestinal sites (C46.4)
    Type 2 Excludes
    • gastrointestinal stromal tumors (C49.A-)
    Malignant neoplasms of digestive organs

  • C22 ICD-10-CM Diagnosis Code C22

    Malignant neoplasm of liver and intrahepatic bile ducts

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • malignant neoplasm of biliary tract NOS (C24.9)
    • secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)
    Use Additional
    • code to identify:
    • alcohol abuse and dependence (F10.-)
    • hepatitis B (B16.-, B18.0-B18.1)
    • hepatitis C (B17.1-, B18.2)
    Malignant neoplasm of liver and intrahepatic bile ducts
Approximate Synonyms
  • Cancer of the liver
  • Malignant neoplasm of liver
Clinical Information
  • Your liver is the largest organ inside your body. It filters harmful substances from the blood, digests fats from food and stores the sugar that your body uses for energy. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver. Risk factors for primary liver cancer include
    • having hepatitis
    • having cirrhosis, or scarring of liver
    • being male
    • low weight at birth
    symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms and the cancer may not be found until it is advanced. This makes it harder to treat. Treatment options include surgery, radiation, chemotherapy or liver transplantation. nih: national cancer institute
ICD-10-CM C22.9 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):
  • 435 Malignancy of hepatobiliary system or pancreas with mcc
  • 436 Malignancy of hepatobiliary system or pancreas with cc
  • 437 Malignancy of hepatobiliary system or pancreas without cc/mcc

Convert C22.9 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change
ICD-10-CM Codes Adjacent To C22.9 C21.2 Malignant neoplasm of cloacogenic zone C21.8 Malignant neoplasm of overlapping sites of rectum, anus and anal canal C22 Malignant neoplasm of liver and intrahepatic bile ducts C22.0 Liver cell carcinoma C22.1 Intrahepatic bile duct carcinoma C22.2 Hepatoblastoma C22.3 Angiosarcoma of liver C22.4 Other sarcomas of liver C22.7 Other specified carcinomas of liver C22.8 Malignant neoplasm of liver, primary, unspecified as to type C22.9 Malignant neoplasm of liver, not specified as primary or secondary C23 Malignant neoplasm of gallbladder C24 Malignant neoplasm of other and unspecified parts of biliary tract C24.0 Malignant neoplasm of extrahepatic bile duct C24.1 Malignant neoplasm of ampulla of Vater C24.8 Malignant neoplasm of overlapping sites of biliary tract C24.9 Malignant neoplasm of biliary tract, unspecified C25 Malignant neoplasm of pancreas C25.0 Malignant neoplasm of head of pancreas C25.1 Malignant neoplasm of body of pancreas C25.2 Malignant neoplasm of tail of pancreas

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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