2022 ICD-10-CM Diagnosis Code C91.00

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2026

  1. ICD-10-CM Codes
    2. ›
  2. C00-D49
    3. ›
  3. C81-C96
    4. ›
  4. C91-
    5. ›
  5. 2026 ICD-10-CM Diagnosis Code C91.00
2026 ICD-10-CM Diagnosis Code C91.00

Acute lymphoblastic leukemia not having achieved remission

    2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 Billable/Specific Code
  • C91.00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2026 edition of ICD-10-CM C91.00 became effective on October 1, 2025.
  • This is the American ICD-10-CM version of C91.00 - other international versions of ICD-10 C91.00 may differ.
Applicable To
  • Acute lymphoblastic leukemia with failed remission
  • Acute lymphoblastic leukemia NOS
The following code(s) above C91.00 contain annotation back-referencesAnnotation Back-ReferencesIn this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to C91.00:
  • C00-D49 2026 ICD-10-CM Range C00-D49

    NeoplasmsNote
    • Functional activity
    • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
    • Morphology [Histology]
    • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
    • Primary malignant neoplasms overlapping site boundaries
    • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
    • Malignant neoplasm of ectopic tissue
    • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
    Neoplasms

  • C81-C96 2026 ICD-10-CM Range C81-C96

    Malignant neoplasms of lymphoid, hematopoietic and related tissueType 2 Excludes
    • Kaposi's sarcoma of lymph nodes (C46.3)
    • secondary and unspecified neoplasm of lymph nodes (C77.-)
    • secondary neoplasm of bone marrow (C79.52)
    • secondary neoplasm of spleen (C78.89)
    Malignant neoplasms of lymphoid, hematopoietic and related tissue

  • C91 ICD-10-CM Diagnosis Code C91

    Lymphoid leukemia

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 Non-Billable/Non-Specific Code
    Type 1 Excludes
    • personal history of leukemia (Z85.6)
    Lymphoid leukemia
  • C91.0 ICD-10-CM Diagnosis Code C91.0

    Acute lymphoblastic leukemia [ALL]

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 Non-Billable/Non-Specific Code
    Note
    • Codes in subcategory C91.0- should only be used for T-cell and B-cell precursor leukemia
    Acute lymphoblastic leukemia [ALL]
Approximate Synonyms
  • Acute lymphoid leukemia
  • Acute lymphoid leukemia with central nervous system involvement
  • Common acute lymphoblastic leukemia
  • Leukemia acute lymphocytic w/ cns involvement
  • Leukemia, acute lymphoblastic, common
  • Leukemia, acute lymphoid
  • Leukemia, pre b cell, acute lymphoblastic
  • Leukemia, t cell, acute lymphoblastic
  • Pre b-cell acute lymphoblastic leukemia
  • T-cell acute lymphoblastic leukemia
Clinical Information
  • A progressive, proliferative disease of blood cells, originating from immature lymphoid cells.
  • Acute leukemia in which lymphoblasts and their progenitor cells predominate; the most common childhood cancer and accounts for 20 percent of adult acute leukemia; common all antigen (calla) expressed in most cases.
  • An aggressive (fast-growing) type of leukemia (blood cancer) in which too many lymphoblasts (immature white blood cells) are found in the blood and bone marrow.
  • leukemia is cancer of the white blood cells. White blood cells help your body fight infection. Your blood cells form in your bone marrow. In leukemia, however, the bone marrow produces abnormal white blood cells. These cells crowd out the healthy blood cells, making it hard for blood to do its work. In acute lymphocytic leukemia (all), there are too many of specific types of white blood cells called lymphocytes or lymphoblasts. All is the most common type of cancer in children.possible risk factors for all include being male, being white, previous chemotherapy treatment, exposure to radiation, and for adults, being older than 70.symptoms of all include:
    • weakness or feeling tired
    • fever
    • easy bruising or bleeding
    • bleeding under the skin
    • shortness of breath
    • weight loss or loss of appetite
    • pain in the bones or stomach
    • pain or a feeling of fullness below the ribs
    • painless lumps in the neck, underarm, stomach, or groin
    tests that examine the blood and bone marrow diagnose all. Treatments include chemotherapy, radiation therapy, stem cell transplants, and targeted immune therapy. Once the leukemia is in remission, you need additional treatment to make sure that it does not come back. nih: national cancer institute
  • Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. It includes the acute b lymphoblastic leukemia and acute t lymphoblastic leukemia.
ICD-10-CM C91.00 is grouped within Diagnostic Related Group(s) (MS-DRG v43.0):
  • 820 Lymphoma and leukemia with major o.r. Procedures with mcc
  • 821 Lymphoma and leukemia with major o.r. Procedures with cc
  • 822 Lymphoma and leukemia with major o.r. Procedures without cc/mcc
  • 834 Acute leukemia with mcc
  • 835 Acute leukemia with cc
  • 836 Acute leukemia without cc/mcc
  • 837 Chemotherapy with acute leukemia as secondary diagnosis or with high dose chemotherapy agent with mcc
  • 838 Chemotherapy with acute leukemia as secondary diagnosis with cc or high dose chemotherapy agent
  • 839 Chemotherapy with acute leukemia as secondary diagnosis without cc/mcc
  • 850 Acute leukemia with other procedures

Convert C91.00 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change
  • 2026 (effective 10/1/2025): No change
ICD-10-CM Codes Adjacent To C91.00 C90.2 Extramedullary plasmacytoma C90.20 …… not having achieved remission C90.21 …… in remission C90.22 …… in relapse C90.3 Solitary plasmacytoma C90.30 …… not having achieved remission C90.31 …… in remission C90.32 …… in relapse C91 Lymphoid leukemia C91.0 Acute lymphoblastic leukemia [ALL] C91.00 Acute lymphoblastic leukemia not having achieved remission C91.01 Acute lymphoblastic leukemia, in remission C91.02 Acute lymphoblastic leukemia, in relapse C91.1 Chronic lymphocytic leukemia of B-cell type C91.10 …… not having achieved remission C91.11 …… in remission C91.12 …… in relapse C91.3 Prolymphocytic leukemia of B-cell type C91.30 …… not having achieved remission C91.31 …… in remission C91.32 …… in relapse

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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