2022 ICD-10-CM Diagnosis Code G35: Multiple Sclerosis

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2025

  1. ICD-10-CM Codes
    2. ›
  2. G00-G99
    3. ›
  3. G35-G37
    4. ›
  4. G35-
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  5. 2025 ICD-10-CM Diagnosis Code G35
2025 ICD-10-CM Diagnosis Code G35

Multiple sclerosis

    2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
  • G35 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes.
  • The 2025 edition of ICD-10-CM G35 became effective on October 1, 2024.
  • This is the American ICD-10-CM version of G35 - other international versions of ICD-10 G35 may differ.
Applicable To
  • Disseminated multiple sclerosis
  • Generalized multiple sclerosis
  • Multiple sclerosis NOS
  • Multiple sclerosis of brain stem
  • Multiple sclerosis of cord
The following code(s) above G35 contain annotation back-referencesAnnotation Back-ReferencesIn this context, annotation back-references refer to codes that contain:
  • Applicable To annotations, or
  • Code Also annotations, or
  • Code First annotations, or
  • Excludes1 annotations, or
  • Excludes2 annotations, or
  • Includes annotations, or
  • Note annotations, or
  • Use Additional annotations
that may be applicable to G35:
  • G00-G99 2025 ICD-10-CM Range G00-G99

    Diseases of the nervous systemType 2 Excludes
    • certain conditions originating in the perinatal period (P04-P96)
    • certain infectious and parasitic diseases (A00-B99)
    • complications of pregnancy, childbirth and the puerperium (O00-O9A)
    • congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
    • endocrine, nutritional and metabolic diseases (E00-E88)
    • injury, poisoning and certain other consequences of external causes (S00-T88)
    • neoplasms (C00-D49)
    • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
    Diseases of the nervous system

Approximate Synonyms
  • Chronic progressive multiple sclerosis
  • Dementia due to multiple sclerosis w behavioral disturbance
  • Dementia due to multiple sclerosis with altered behavior
  • Dementia from multiple sclerosis
  • Exacerbation of multiple sclerosis
  • Multiple sclerosis (ms), chronic/progressive
  • Multiple sclerosis (ms), exacerbation
  • Multiple sclerosis (ms), primary progressive
  • Multiple sclerosis (ms), relapsing progressive
  • Multiple sclerosis (ms), relapsing remitting
  • Multiple sclerosis (ms), secondary progressive
  • Primary progressive multiple sclerosis
  • Relapsing remitting multiple sclerosis
  • Remittent-progressive multiple sclerosis
  • Secondary progressive multiple sclerosis
Clinical Information
  • A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals.
  • A progressive autoimmune disorder affecting the central nervous system resulting in demyelination. Patients develop physical and cognitive impairments that correspond with the affected nerve fibers.
  • An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see multiple sclerosis, relapsing-remitting), but acute fulminating and chronic progressive forms (see multiple sclerosis, chronic progressive) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
  • Chronic disease characterized by presence of numerous areas of demyelination in the central nervous system with symptoms such as weakness, incoordination, paresthesis, and speech disturbances; the etiology is unknown.
  • Multiple sclerosis (ms) is a nervous system disease that affects your brain and spinal cord. It damages the myelin sheath, the material that surrounds and protects your nerve cells. This damage slows down or blocks messages between your brain and your body, leading to the symptoms of ms. They can include
    • visual disturbances
    • muscle weakness
    • trouble with coordination and balance
    • sensations such as numbness, prickling, or "pins and needles"
    • thinking and memory problems
    no one knows what causes ms. It may be an autoimmune disease, which happens when your body attacks itself. Multiple sclerosis affects women more than men. It often begins between the ages of 20 and 40. Usually, the disease is mild, but some people lose the ability to write, speak or walk. There is no cure for ms, but medicines may slow it down and help control symptoms. Physical and occupational therapy may also help.
ICD-10-CM G35 is grouped within Diagnostic Related Group(s) (MS-DRG v42.0):
  • 058 Multiple sclerosis and cerebellar ataxia with mcc
  • 059 Multiple sclerosis and cerebellar ataxia with cc
  • 060 Multiple sclerosis and cerebellar ataxia without cc/mcc

Convert G35 to ICD-9-CM

Code History
  • 2016 (effective 10/1/2015): New code (first year of non-draft ICD-10-CM)
  • 2017 (effective 10/1/2016): No change
  • 2018 (effective 10/1/2017): No change
  • 2019 (effective 10/1/2018): No change
  • 2020 (effective 10/1/2019): No change
  • 2021 (effective 10/1/2020): No change
  • 2022 (effective 10/1/2021): No change
  • 2023 (effective 10/1/2022): No change
  • 2024 (effective 10/1/2023): No change
  • 2025 (effective 10/1/2024): No change
Code annotations containing back-references to G35:
  • Code First: F02, F48.2 ICD-10-CM Diagnosis Code F02

    Dementia in other diseases classified elsewhere

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Non-Billable/Non-Specific Code
    Code First
    • the underlying physiological condition, such as:
    • Alzheimer's (G30.-)
    • cerebral lipidosis (E75.4)
    • Creutzfeldt-Jakob disease (A81.0-)
    • epilepsy and recurrent seizures (G40.-)
    • frontotemporal dementia (G31.09)
    • hepatolenticular degeneration (E83.01)
    • human immunodeficiency virus [HIV] disease (B20)
    • Huntington's disease (G10)
    • hypercalcemia (E83.52)
    • hypothyroidism, acquired (E00-E03.-)
    • intoxications (T36-T65)
    • Jakob-Creutzfeldt disease (A81.0-)
    • multiple sclerosis (G35)
    • neurocognitive disorder with Lewy bodies (G31.83)
    • neurosyphilis (A52.17)
    • niacin deficiency [pellagra] (E52)
    • other frontotemporal neurocognitive disorder (G31.90)
    • Parkinson's disease (G20.-)
    • Pick's disease (G31.01)
    • polyarteritis nodosa (M30.0)
    • prion disease (A81.9)
    • systemic lupus erythematosus (M32.-)
    • traumatic brain injury (S06.-)
    • trypanosomiasis (B56.-, B57.-)
    • vitamin B deficiency (E53.8)
    Includes
    • Major neurocognitive disorder in other diseases classified elsewhere
    Type 1 Excludes
    • mild neurocognitive disorder due to known physiological condition with or without behavioral disturbance (F06.7-)
    Type 2 Excludes
    • dementia in alcohol and psychoactive substance disorders (F10-F19, with .17, .27, .97)
    • vascular dementia (F01.5-, F01.A-, F01.B-, F01.C-)
    ICD-10-CM Diagnosis Code F48.2

    Pseudobulbar affect

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
    Applicable To
    • Involuntary emotional expression disorder
    Code First
    • underlying cause, if known, such as:
    • amyotrophic lateral sclerosis (G12.21)
    • multiple sclerosis (G35)
    • sequelae of cerebrovascular disease (I69.-)
    • sequelae of traumatic intracranial injury (S06.-)
  • Type 1 Excludes: G37.3 ICD-10-CM Diagnosis Code G37.3

    Acute transverse myelitis in demyelinating disease of central nervous system

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
    Applicable To
    • Acute transverse myelitis NOS
    • Acute transverse myelopathy
    Type 1 Excludes
    • acute flaccid myelitis (G04.82)
    • multiple sclerosis (G35)
    • neuromyelitis optica [Devic] (G36.0)
  • Type 2 Excludes: G04 ICD-10-CM Diagnosis Code G04

    Encephalitis, myelitis and encephalomyelitis

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Non-Billable/Non-Specific Code
    Includes
    • acute ascending myelitis
    • meningoencephalitis
    • meningomyelitis
    Type 1 Excludes
    • encephalopathy NOS (G93.40)
    Type 2 Excludes
    • acute transverse myelitis (G37.3)
    • alcoholic encephalopathy (G31.2)
    • multiple sclerosis (G35)
    • myalgic encephalomyelitis (G93.32)
    • subacute necrotizing myelitis (G37.4)
    • toxic encephalitis (G92.8)
    • toxic encephalopathy (G92.8)

Diagnosis Index entries containing back-references to G35:

  • Dementia (degenerative (primary)) (persisting) (unspecified severity) (without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety) F03.90ICD-10-CM Diagnosis Code F03.90

    Unspecified dementia, unspecified severity, without behavioral disturbance, psychotic disturbance, mood disturbance, and anxiety

      2016 2017 2018 2019 2020 2021 2022 2023 - Revised Code 2024 2025 Billable/Specific Code Adult Dx (15-124 years)
    Applicable To
    • Dementia NOS
    • in (due to)
      • multiple
        • sclerosis G35 - see also Dementia, in, diseases specified elsewhere
          • with behavioral disturbance G35 - see also Dementia, in, diseases specified elsewhere
  • Demyelination, demyelinization
    • global G35
  • Disease, diseased - see also Syndrome
    • demyelinating, demyelinizating (nervous system) G37.9ICD-10-CM Diagnosis Code G37.9

      Demyelinating disease of central nervous system, unspecified

        2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
      • multiple sclerosis G35
  • Myelosclerosis D75.89ICD-10-CM Diagnosis Code D75.89

    Other specified diseases of blood and blood-forming organs

      2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
    • disseminated, of nervous system G35
  • Sclérose en plaques G35
  • Sclerosis, sclerotic
    • brain (generalized) (lobular) G37.9ICD-10-CM Diagnosis Code G37.9

      Demyelinating disease of central nervous system, unspecified

        2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
      • disseminated G35
      • insular G35
      • miliary G35
      • multiple G35
      • stem, multiple G35
    • combined (spinal cord) - see also Degeneration, combined
      • multiple G35
    • spinal (cord) (progressive) G95.89ICD-10-CM Diagnosis Code G95.89

      Other specified diseases of spinal cord

        2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Billable/Specific Code
      Applicable To
      • Cord bladder NOS
      • Drug-induced myelopathy
      • Radiation-induced myelopathy
      Type 1 Excludes
      • myelopathy NOS (G95.9)
      • combined - see also Degeneration, combined
        • multiple G35
      • disseminated G35
      • multiple G35
    • ascending multiple G35
    • bulbar, multiple G35
    • cerebrospinal G35 (disseminated) (multiple)
    • disseminated G35
    • dorsal G35
    • insular G35
    • multiple G35 (brain stem) (cerebral) (generalized) (spinal cord)
    • plaques G35

ICD-10-CM Codes Adjacent To G35 G31.84 Mild cognitive impairment of uncertain or unknown etiology G31.85 Corticobasal degeneration G31.86 Alexander disease G31.89 Other specified degenerative diseases of nervous system G31.9 Degenerative disease of nervous system, unspecified G32 Other degenerative disorders of nervous system in diseases classified elsewhere G32.0 Subacute combined degeneration of spinal cord in diseases classified elsewhere G32.8 Other specified degenerative disorders of nervous system in diseases classified elsewhere G32.81 Cerebellar ataxia in diseases classified elsewhere G32.89 Other specified degenerative disorders of nervous system in diseases classified elsewhere G35 Multiple sclerosis G36 Other acute disseminated demyelination G36.0 Neuromyelitis optica [Devic] G36.1 Acute and subacute hemorrhagic leukoencephalitis [Hurst] G36.8 Other specified acute disseminated demyelination G36.9 Acute disseminated demyelination, unspecified G37 Other demyelinating diseases of central nervous system G37.0 Diffuse sclerosis of central nervous system G37.1 Central demyelination of corpus callosum G37.2 Central pontine myelinolysis G37.3 Acute transverse myelitis in demyelinating disease of central nervous system

Reimbursement claims with a date of service on or after October 1, 2015 require the use of ICD-10-CM codes.

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