221937 - Gene ResultFOXK1 Forkhead Box K1 [ (human)] - NCBI

Trang chủ » Box K1 » 221937 - Gene ResultFOXK1 Forkhead Box K1 [ (human)] - NCBI

Có thể bạn quan tâm

Dot gov

The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Gene

Genes and mapped phenotypes

Search databaseAll DatabasesAssemblyBiocollectionsBioProjectBioSampleBooksClinVarConserved DomainsdbGaPdbVarGeneGenomeGEO DataSetsGEO ProfilesGTRIdentical Protein GroupsMedGenMeSHNLM CatalogNucleotideOMIMPMCPopSetProteinProtein ClustersProtein Family ModelsPubChem BioAssayPubChem CompoundPubChem SubstancePubMedSNPSRAStructureTaxonomyToolKitToolKitAllToolKitBookghSearch termSearch
  • Advanced
  • Help

Result Filters

  • Gene sources

    Clear
    • Genomic

  • Categories

    Clear
    • Annotated genes
    • Protein-coding

  • Sequence content

    Clear
    • CCDS
    • Ensembl
    • RefSeq

  • Status

    Clear
    • Current(1)

  • Chromosome locations

    Clear
      more...

      Chromosome locations

      Select an organism by typing or scrollingChromosomeFromToApply
  • Clear all
  • Show additional filters
    • x

    Additional filters

    • Gene sources
    • Categories
    • Sequence content
    • Status
    • Chromosome locations
    • Search fields
    Show
S I D E B A R
  • Full Report
Format
  • Full Report
  • Full Report (text)
  • Expression
  • Gene Table
  • Gene Table (text)
  • GeneRIF
  • Summary
  • Summary (text)
  • Tabular
  • Tabular (text)
  • ASN.1
  • XML
  • UI List
Apply

Send to:

Choose Destination
  • File
  • Clipboard
  • Collections
  • FormatFull Report (text)Gene Table (text)Summary (text)Tabular (text)ASN.1XMLUI List
Create FileAdd to ClipboardAdd to Collections FOXK1 forkhead box K1 [ Homo sapiens (human) ] Gene ID: 221937, updated on 27-Nov-2024 Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

File name Download

Summary

Go to the top of the page Help Official Symbol FOXK1provided by HGNC Official Full Name forkhead box K1provided by HGNC Primary source HGNC:HGNC:23480 See related Ensembl:ENSG00000164916 MIM:616302; AllianceGenome:HGNC:23480 Gene type protein coding RefSeq status VALIDATED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as FOXK1L Summary Enables 14-3-3 protein binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and transcription cis-regulatory region binding activity. Involved in several processes, including intracellular glucose homeostasis; negative regulation of autophagy; and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024] Expression Ubiquitous expression in brain (RPKM 5.1), testis (RPKM 3.8) and 25 other tissues See more Orthologs mouse all NEW Try the new Gene table Try the new Transcript table

Genomic context

Go to the top of the page Help See FOXK1 in Genome Data Viewer Location: 7p22.1 Exon count: 9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (4682295..4771442)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (4799494..4888656)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (4721926..4811073)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help Go to reference sequence details

Genomic Sequence: NC_000007.14 Chromosome 7 Reference GRCh38.p14 Primary Assembly NC_060931.1 Chromosome 7 Alternate T2T-CHM13v2.0 NC_000007.13 Chromosome 7 Reference GRCh37.p13 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help See details Tissue-specific circular RNA induction during human fetal development HPA RNA-seq normal tissues RNA sequencing of total RNA from 20 human tissues
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance. Zhang Z, et al. Cancer Lett, 2024 Sep 1. PMID 39094826
  2. FOXK1 plays an oncogenic role in the progression of hilar cholangiocarcinoma. Feng Y, et al. Mol Med Rep, 2021 Feb. PMID 33300075, Free PMC Article
  3. High FOXK1 expression correlates with poor outcomes in hepatocellular carcinoma and regulates stemness of hepatocellular carcinoma cells. Cao H, et al. Life Sci, 2019 Jul 1. PMID 31054270
  4. Knockdown of FOXK1 suppresses liver cancer cell viability by inhibiting glycolysis. Cui H, et al. Life Sci, 2018 Nov 15. PMID 30312701
  5. Nuclear-cytoplasmic shuttling protein PP2A(B56) contributes to mTORC1-dependent dephosphorylation of FOXK1. Nakatsumi H, et al. Genes Cells, 2018 Jul. PMID 29845697

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance. Title: Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance.
  2. Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis. Title: Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis.
  3. FOXK1 upregulation is correlated with tumor progression and tumor associated macrophages infiltration in renal cell carcinoma. Title: FOXK1 upregulation is correlated with tumor progression and tumor associated macrophages infiltration in renal cell carcinoma.
  4. FOXK1 regulates epithelial-mesenchymal transition and radiation sensitivity in nasopharyngeal carcinoma via the JAK/STAT3 signaling pathway. Title: FOXK1 regulates epithelial-mesenchymal transition and radiation sensitivity in nasopharyngeal carcinoma via the JAK/STAT3 signaling pathway.
  5. FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinoma. Title: FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinoma.
  6. TRPM2-AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR-497-5p. Title: TRPM2-AS promotes paclitaxel resistance in prostate cancer by regulating FOXK1 via sponging miR-497-5p.
  7. Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1. Title: Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1.
  8. Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. Title: Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.
  9. circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma. Title: circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma.
  10. Hsa_circ_0041103 induces proliferation, migration and invasion in bladder cancer via the miR-107/FOXK1 axis. Title: Hsa_circ_0041103 induces proliferation, migration and invasion in bladder cancer via the miR-107/FOXK1 axis.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene network analysis in a pediatric cohort identifies novel lung function genes.EBI GWAS CatalogEBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

  • GDB:4585535 (e-PCR)
    • UniSTS:49158
  • D11S2921 (e-PCR)
    • UniSTS:152074
  • GDB:434012 (e-PCR)
    • UniSTS:157204
  • D7S2724 (e-PCR)
    • UniSTS:1306
  • PMC156606P1 (e-PCR)
    • UniSTS:271408
  • D8S2278 (e-PCR)
    • UniSTS:473906
  • D8S2279 (e-PCR)
    • UniSTS:473907
  • GDB:3778183 (e-PCR)
    • UniSTS:34868
  • GDB:1317210 (e-PCR)
    • UniSTS:19769
  • RH45530 (e-PCR)
    • UniSTS:44618
  • GDB:314949 (e-PCR)
    • UniSTS:156503
  • L18426 (e-PCR)
    • UniSTS:34648
  • D15S1477 (e-PCR)
    • UniSTS:474482
  • D1S1423 (e-PCR)
    • UniSTS:149619
  • D1S1425 (e-PCR)
    • UniSTS:149621
  • D2S1254 (e-PCR)
    • UniSTS:24950
  • G35510 (e-PCR)
    • UniSTS:44150
  • D11S3114 (e-PCR)
    • UniSTS:152207
  • GDB:4585566 (e-PCR)
    • UniSTS:19641
  • GDB:4585474 (e-PCR)
    • UniSTS:40893
  • A008Y33 (e-PCR)
    • UniSTS:79067
  • FOXK1 (e-PCR)
    • UniSTS:519388
  • RH92527 (e-PCR)
    • UniSTS:83957

Homology

  • NCBI Orthologs
    • Orthologs from OrthoDB

Clone Names

  • FLJ14977

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IPI Inferred from Physical Interactionmore info PubMed 
enables DNA-binding transcription factor activity IDA Inferred from Direct Assaymore info PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA Inferred from Biological aspect of Ancestormore info  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA Inferred from Sequence Alignmentmore info  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA Inferred from Direct Assaymore info PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA Inferred from Biological aspect of Ancestormore info  
enables protein binding IPI Inferred from Physical Interactionmore info PubMed 
enables sequence-specific double-stranded DNA binding IDA Inferred from Direct Assaymore info PubMed 
enables transcription cis-regulatory region binding IDA Inferred from Direct Assaymore info PubMed 
Process Evidence Code Pubs
acts_upstream_of canonical glycolysis IDA Inferred from Direct Assaymore info PubMed 
involved_in cell differentiation IEA Inferred from Electronic Annotationmore info  
involved_in intracellular glucose homeostasis IDA Inferred from Direct Assaymore info PubMed 
involved_in muscle organ development IEA Inferred from Electronic Annotationmore info  
involved_in negative regulation of DNA-templated transcription IDA Inferred from Direct Assaymore info PubMed 
involved_in negative regulation of autophagy IDA Inferred from Direct Assaymore info PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA Inferred from Electronic Annotationmore info  
involved_in positive regulation of DNA-templated transcription IDA Inferred from Direct Assaymore info PubMed 
involved_in regulation of glucose metabolic process IDA Inferred from Direct Assaymore info PubMed 
involved_in regulation of transcription by RNA polymerase II IBA Inferred from Biological aspect of Ancestormore info  
involved_in response to starvation IDA Inferred from Direct Assaymore info PubMed 
Component Evidence Code Pubs
located_in chromatin ISA Inferred from Sequence Alignmentmore info  
located_in cytoplasm IDA Inferred from Direct Assaymore info PubMed 
located_in nucleoplasm TAS Traceable Author Statementmore info  
located_in nucleus IDA Inferred from Direct Assaymore info PubMed 

General protein information

Go to the top of the page Help Preferred Names forkhead box protein K1 Names MNF myocyte nuclear factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037165.2 → NP_001032242.1  forkhead box protein K1

    See identical proteins and their annotated locations for NP_001032242.1

    Status: VALIDATED

    Source sequence(s) AC072054, AC092428, AC092610 Consensus CDS CCDS34591.1 UniProtKB/Swiss-Prot P85037 Related ENSP00000328720.4, ENST00000328914.5 Conserved Domains (3) summary COG1716Location:102 → 204 FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms] cd00060Location:110 → 203 FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ... pfam00250Location:305 → 391 Forkhead; Forkhead domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range 4682295..4771442 Download GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range 4799494..4888656 Download GenBank, FASTA, Sequence Viewer (Graphics)
Go to the top of the page Help
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P85037.1 GenPept UniProtKB/Swiss-Prot:P85037
Go to the top of the pageHelp

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
  • Interologous Interaction Database
    • Interologous Interaction Database
  • MilliporeSigma
    • Foxk1 products
Molecular Biology Databases
  • Bgee database
    • FOXK1 gene expression
  • BioGPS
    • BioGPS
  • BioGRID Open Repository of CRISPR Screens (ORCS)
    • BioGRID CRISPR Screen Phenotypes (109 hits/1307 screens)
  • CTD: Comparative Toxicogenomics Database
    • CTD: Comparative Toxicogenomics Database - FOXK1
  • Domain Mapping of Disease Mutations
    • FOXK1
  • Eukaryotic Promoter Database
    • FOXK1_1
  • GlyGen glycoinformatics resource
    • GlyGen glycoinformatics resource
  • Human eFP Browser
    • Human eFP Browser
    • Human eFP Browser
    • Human eFP Browser
  • Ingenuity Pathways Analysis
    • Ingenuity Pathways Analysis
  • InnateDB
    • InnateDB
  • InterMine
    • InterMine
  • Kyoto Encyclopedia of Genes and Genomes
    • Kyoto Encyclopedia of Genes and Genomes
  • OMA Browser: Orthologous MAtrix
    • OMA Browser: Orthologous MAtrix
  • OrthoDB catalog of orthologs
    • Orthologs
  • PhosphoSitePlus
    • PhosphoSitePlus® - comprehensive post-translational modification resource
  • The Gene Wiki
    • The Gene Wiki
  • The Weizmann Institute of Science GeneCards and MalaCards databases
    • GeneCard for FOXK1
Research Materials
  • Addgene Non-profit plasmid repository
    • Get Plasmids - Addgene
  • Bio-Techne
    • FoxK1 Antibodies
    • FoxK1 Proteins
  • ExactAntigen/Labome
    • reagent review
    • reagents
  • GenScript latest version of gene cDNA ORF Clone
    • GenScript latest version of gene cDNA ORF Clone
  • GeneCopoeia Inc.
    • Order full-length ORF clone
    • Order shRNA clones
    • Order miRNA target clones
  • OriGene
    • Order Foxk1 cDNA clone/Protein/Antibody/RNAi
Tools
  • GeneMANIA
    • GeneMANIA
Miscellaneous
  • Reactome
    • Reactome Event:Metabolism of proteins
    • Reactome Entity:P85037
Hide sidebar >>

Supplemental Content

Table of contents

  • Summary
  • Genomic context
  • Genomic regions, transcripts, and products
  • Expression
  • Bibliography
  • Phenotypes
  • Variation
  • Interactions
  • General gene information Markers, Clone Names, Homology, Gene Ontology
  • General protein information
  • NCBI Reference Sequences (RefSeq)
  • Related sequences
  • Additional links

Genome Browsers

  • Loading...

Related information

  • BioAssay by Target (List) BioAssays related to the gene by protein target or RNAi target
  • BioAssay by Target (Summary) Summarized PubChem Data on the gene, showing the active data by default
  • BioAssay, by Gene target PubChem BioAssays done on the Gene target
  • BioAssays, RNAi Target, Active BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record
  • BioAssays, RNAi Target, Tested BioAssays that contain the gene as the target of a RNAi reagent
  • BioProjects BioProjects related to a gene
  • BioSystems BioSystems
  • CCDS Link to CCDS
  • ClinVar Related medical variations
  • Conserved Domains Related CDD
  • dbVar Link from Gene to dbVar
  • Full text in PMC PMC links
  • Full text in PMC_nucleotide Full text in PubMedCentral identified from shared sequence links
  • Functional Class Functional class of the sequence domain architecture
  • Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side
  • Genome Related Genome
  • GEO Profiles Related GEO
  • GTR Tests for this gene in the NIH Genetic Testing Registry
  • HomoloGene Related HomoloGene
  • Nucleotide Link to related Nucleotide entry
  • OMIM Link to related OMIM entry
  • Probe Related Probe entry
  • Protein Link to related protein entry
  • PubChem Compound PubChem Compounds
  • PubChem Substance PubChem Substances
  • PubMed Link to related PubMed entry
  • PubMed (GeneRIF) Link to related PubMed article from GeneRIFs
  • PubMed (OMIM) Gene links to PubMed derived from omim_pubmed_cited links
  • PubMed(nucleotide/PMC) Citations in PubMed identified from shared sequence and PMC links.
  • RefSeq Proteins Link to Protein RefSeqs
  • RefSeq RNAs Link to Nucleotide RefSeq RNAs
  • Related gene-specific medical variations Related medical variations
  • SNP Related SNP records
  • Taxonomy Link to related taxonomy entry
  • Variation Viewer Related Variants

Links to other resources

  • HGNC
  • Ensembl
  • AllianceGenome
  • AceView
  • UCSC
  • KEGG
  • Reactome

General information

  • About Gene
  • FAQ
  • FTP site
  • Help
  • My NCBI help
  • NCBI Handbook
  • Statistics

Related sites

  • BLAST
  • Genome
  • BioProject
  • Genome Data Viewer
  • GEO
  • OMIM
  • Probe
  • RefSeq

Feedback

  • Contact Help Desk
  • Submit Correction
  • Submit GeneRIF

Subscription

  • RefSeq

Recent activity

Clear Turn Off Turn On
  • FOXK1 forkhead box K1 [Homo sapiens] FOXK1 forkhead box K1 [Homo sapiens]Gene ID:221937 Gene

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more... Follow NCBI Twitter Facebook LinkedIn GitHub NCBI Insights Blog

Connect with NLM

  • Twitter
  • Facebook
  • Youtube

National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894

Web Policies FOIA HHS Vulnerability Disclosure

Help Accessibility Careers

  • NLM
  • NIH
  • HHS
  • USA.gov

Từ khóa » Box K1