3269 - Gene ResultHRH1 Histamine Receptor H1 [ (human)] - NCBI

The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Gene

Genes and mapped phenotypes

Search databaseAll DatabasesAssemblyBiocollectionsBioProjectBioSampleBooksClinVarConserved DomainsdbGaPdbVarGeneGenomeGEO DataSetsGEO ProfilesGTRIdentical Protein GroupsMedGenMeSHNLM CatalogNucleotideOMIMPMCProteinProtein ClustersProtein Family ModelsPubChem BioAssayPubChem CompoundPubChem SubstancePubMedSNPSRAStructureTaxonomyToolKitToolKitAllToolKitBookghSearch termSearch

• Advanced
• Help

Result Filters

• Gene sources

  Clear
  • Genomic

• Categories

  Clear
  • Alternatively spliced
  • Annotated genes
  • Protein-coding

• Sequence content

  Clear
  • CCDS
  • Ensembl
  • RefSeq

• Status

  Clear
  • Current(1)

• Chromosome locations

  Clear
  more...

  Chromosome locations

  Select an organism by typing or scrollingChromosomeFromToApply

• Clear all

• Show additional filters
x

Additional filters

• Gene sources
• Categories
• Sequence content
• Status
• Chromosome locations
• Search fields
Show

S I D E B A R

• Full Report

Format

• Full Report
• Full Report (text)
• Expression
• Gene Table
• Gene Table (text)
• GeneRIF
• Summary
• Summary (text)
• Tabular
• Tabular (text)
• ASN.1
• XML
• UI List

Apply

Send to:

Choose Destination

• File
• Clipboard
• Collections

• FormatFull Report (text)Gene Table (text)Summary (text)Tabular (text)ASN.1XMLUI List

Create FileAdd to ClipboardAdd to Collections HRH1 histamine receptor H1 [ Homo sapiens (human) ] Gene ID: 3269, updated on 25-Nov-2025

Download Datasets

Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

File name Download

Summary

Go to the top of the page Help Official Symbol HRH1provided by HGNC Official Full Name histamine receptor H1provided by HGNC Primary source HGNC:HGNC:5182 See related Ensembl:ENSG00000196639 MIM:600167; AllianceGenome:HGNC:5182 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as H1R; H1-R; HH1R; hisH1 Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015] Expression Ubiquitous expression in brain (RPKM 4.0), urinary bladder (RPKM 3.8) and 21 other tissues See more Orthologs mouse all Try the new Gene page Try the new Transcripts and proteins table

Genomic context

Go to the top of the page Help See HRH1 in Genome Data Viewer Location: 3p25.3 Exon count: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (11137238..11263557)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (11131678..11258484)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (11178924..11305243)

Chromosome 3 - NC_000003.12

Genomic regions, transcripts, and products

Go to the top of the page Help Go to reference sequence details

Genomic Sequence: NC_000003.12 Chromosome 3 Reference GRCh38.p14 Primary Assembly NC_060927.1 Chromosome 3 Alternate T2T-CHM13v2.0 NC_000003.11 Chromosome 3 Reference GRCh37.p13 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help See details Tissue-specific circular RNA induction during human fetal development RNA sequencing of total RNA from 20 human tissues HPA RNA-seq normal tissues

• Project title: Tissue-specific circular RNA induction during human fetal development
• Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
• BioProject: PRJNA270632
• Publication: PMID 26076956
• Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

1. Increased brain histamine H1 receptor binding in patients with anorexia nervosa. Yoshizawa M, et al. Biol Psychiatry, 2009 Feb 15. PMID 18814859
2. Linking agonist binding to histamine H1 receptor activation. Jongejan A, et al. Nat Chem Biol, 2005 Jul. PMID 16408006
3. Alternative promoter use and splice variation in the human histamine H1 receptor gene. Swan C, et al. Am J Respir Cell Mol Biol, 2006 Jul. PMID 16484687
4. Dualistic H(1)-mediated effect of histamine on the human isolated intestine. 5. Histamine in cardiovascular and gastrointestinal systems. Poli E, et al. Inflamm Res, 2006 Apr. PMID 16547808
5. Ascorbate enhancement of H1 histamine receptor sensitivity coincides with ascorbate oxidation inhibition by histamine receptors. Dillon PF, et al. Am J Physiol Cell Physiol, 2006 Nov. PMID 16760260

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2. Title: The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2.
2. Histamine H1 Receptor-Mediated JNK Phosphorylation Is Regulated by Gq Protein-Dependent but Arrestin-Independent Pathways. Title: Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways.
3. Histamine H1- and H4-receptor expression in human colon-derived cell lines. Title: Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.
4. Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H1 Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine. Title: Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.
5. Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins. Title: Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins.
6. Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration. Title: Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.
7. Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene. Title: Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene.
8. Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase. Title: Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.
9. P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors. Title: P2X4 Receptors Mediate Ca(2+) Release from Lysosomes in Response to Stimulation of P2X7 and H(1) Histamine Receptors.
10. Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30x30)K Variant in the Histamine H1 Receptor. Title: Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.EBI GWAS CatalogEBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

• D10S275 (e-PCR)
  • UniSTS:147992

• D3S3461 (e-PCR)
  • UniSTS:153907

• SHGC-132075 (e-PCR)
  • UniSTS:173890

• RH79740 (e-PCR)
  • UniSTS:88396

• HRH1_1003 (e-PCR)
  • UniSTS:277327

• HRH1_V259 (e-PCR)
  • UniSTS:277327

• SHGC-148056 (e-PCR)
  • UniSTS:172921

• D3S4194 (e-PCR)
  • UniSTS:2436

• SHGC-148108 (e-PCR)
  • UniSTS:172932

• WI-15608 (e-PCR)
  • UniSTS:29585

• D3S3145 (e-PCR)
  • UniSTS:37830

• SHGC-76733 (e-PCR)
  • UniSTS:67288

• RH36646 (e-PCR)
  • UniSTS:85732

• D3S3138 (e-PCR)
  • UniSTS:37878

Homology

• NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotationmore info
enables histamine receptor activity	IBA Inferred from Biological aspect of Ancestormore info
enables histamine receptor activity	IDA Inferred from Direct Assaymore info	PubMed
enables histamine receptor activity	IEA Inferred from Electronic Annotationmore info
enables histamine receptor activity	ISS Inferred from Sequence or Structural Similaritymore info
enables histamine receptor activity	TAS Traceable Author Statementmore info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assaymore info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotationmore info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similaritymore info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestormore info
involved_in cellular response to histamine	IDA Inferred from Direct Assaymore info	PubMed
involved_in cellular response to histamine	ISS Inferred from Sequence or Structural Similaritymore info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestormore info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similaritymore info
acts_upstream_of_or_within memory	IEA Inferred from Electronic Annotationmore info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similaritymore info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within regulation of synaptic plasticity	IEA Inferred from Electronic Annotationmore info
involved_in regulation of vascular permeability	IEA Inferred from Electronic Annotationmore info
involved_in signal transduction	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within visual learning	IEA Inferred from Electronic Annotationmore info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestormore info
located_in membrane	IEA Inferred from Electronic Annotationmore info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestormore info
is_active_in plasma membrane	IDA Inferred from Direct Assaymore info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assaymore info
located_in plasma membrane	IEA Inferred from Electronic Annotationmore info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similaritymore info
located_in plasma membrane	TAS Traceable Author Statementmore info	PubMed
located_in synapse	IEA Inferred from Electronic Annotationmore info

General protein information

Go to the top of the page Help Preferred Names histamine H1 receptor Names histamine receptor, subclass H1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

1. NM_000861.3 → NP_000852.1  histamine H1 receptor

   See identical proteins and their annotated locations for NP_000852.1

   Status: REVIEWED

   Description Transcript Variant: This variant (4), also known as H/I/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein. Source sequence(s) AC083855, BC060802, BM905371, D28481, DB073635 Consensus CDS CCDS2604.1 UniProtKB/Swiss-Prot A8K047, P35367, Q6P9E5 UniProtKB/TrEMBL A8K7Z2 Related ENSP00000380247.1, ENST00000397056.1 Conserved Domains (1) summary cd15050Location:28 → 479 7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

2. NM_001098211.2 → NP_001091681.1  histamine H1 receptor

   See identical proteins and their annotated locations for NP_001091681.1

   Status: REVIEWED

   Description Transcript Variant: This variant (3), also known as F/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein. Source sequence(s) AC083855, BM905371, D28481, DA372691, DB073635 Consensus CDS CCDS2604.1 UniProtKB/Swiss-Prot A8K047, P35367, Q6P9E5 UniProtKB/TrEMBL A8K7Z2 Related ENSP00000573264.1, ENST00000903205.1 Conserved Domains (1) summary cd15050Location:28 → 479 7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

3. NM_001098212.2 → NP_001091682.1  histamine H1 receptor

   See identical proteins and their annotated locations for NP_001091682.1

   Status: REVIEWED

   Description Transcript Variant: This variant (2), also known as B/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein. Source sequence(s) AC083855, BM905371, BP366267, D28481 Consensus CDS CCDS2604.1 UniProtKB/Swiss-Prot A8K047, P35367, Q6P9E5 UniProtKB/TrEMBL A8K7Z2 Related ENSP00000397028.2, ENST00000431010.3 Conserved Domains (1) summary cd15050Location:28 → 479 7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

4. NM_001098213.2 → NP_001091683.1  histamine H1 receptor

   See identical proteins and their annotated locations for NP_001091683.1

   Status: REVIEWED

   Description Transcript Variant: This variant (1), also known as A/K, represents the longest transcript. Variants 1-4 encode the same protein. Source sequence(s) AC083855, BM905371, D28481, DB073635, DC300229 Consensus CDS CCDS2604.1 UniProtKB/Swiss-Prot A8K047, P35367, Q6P9E5 UniProtKB/TrEMBL A8K7Z2 Related ENSP00000406705.2, ENST00000438284.2 Conserved Domains (1) summary cd15050Location:28 → 479 7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

   Range 11137238..11263557 Download GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

1. NC_060927.1 Alternate T2T-CHM13v2.0

   Range 11131678..11258484 Download GenBank, FASTA, Sequence Viewer (Graphics)

Related sequences

Go to the top of the page Help

Nucleotide		Protein
Heading	Accession and Version

Protein Accession	Links
	GenPept Link	UniProtKB Link
P35367.1	GenPept	UniProtKB/Swiss-Prot:P35367

Additional links

Go to the top of the pageHelp

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

• Interologous Interaction Database
• Interologous Interaction Database
• MilliporeSigma
• Hrh1 products

Molecular Biology Databases

• Bgee database
• HRH1 gene expression
• BioGPS
• BioGPS
• BioGRID Open Repository of CRISPR Screens (ORCS)
• BioGRID CRISPR Screen Phenotypes (17 hits/1370 screens)
• Domain Mapping of Disease Mutations
• HRH1
• Eukaryotic Promoter Database
• HRH1_1
• GlyGen glycoinformatics resource
• GlyGen glycoinformatics resource
• Guide to Pharmacology
• H1 receptor gene
• Human eFP Browser
• Human eFP Browser
• Human eFP Browser
• Human eFP Browser
• Ingenuity Pathways Analysis
• Ingenuity Pathways Analysis
• InnateDB
• InnateDB
• InterMine
• InterMine
• Kyoto Encyclopedia of Genes and Genomes
• Kyoto Encyclopedia of Genes and Genomes
• OMA Browser: Orthologous MAtrix
• OMA Browser: Orthologous MAtrix
• OMA Browser: Orthologous MAtrix
• OMA Browser: Orthologous MAtrix
• OrthoDB catalog of orthologs
• Orthologs
• Pharmacogenomics Knowledge Base
• Annotated Pharmacogenomic Information for HRH1 [ClinPGx]
• PhosphoSitePlus
• PhosphoSitePlus® - comprehensive post-translational modification resource
• The Gene Wiki
• The Gene Wiki
• The Weizmann Institute of Science GeneCards and MalaCards databases
• GeneCard for HRH1

Research Materials

• Addgene Non-profit plasmid repository
• Get Plasmids - Addgene
• Bio-Techne
• Histamine H1R Antibodies
• Histamine H1R Lysates
• Histamine H1R Proteins
• Creative Biogene
• histamine receptor H1
• ExactAntigen/Labome
• reagents
• reagent review
• GenScript latest version of gene cDNA ORF Clone
• GenScript latest version of gene cDNA ORF Clone
• GeneCopoeia Inc.
• Order TALEN/CRISPR clones
• Order miRNA target clones
• Order full-length ORF clone
• GeneTex Inc
• Find Quality Antibodies
• OriGene Technologies
• Order GeneID 3269 cDNA Clone|Lysate|Protein|Antibody|RNAi

Tools

• GeneMANIA
• GeneMANIA

Miscellaneous

• Reactome
• Reactome Event:Signal Transduction
• Reactome Entity:P35367

Hide sidebar >>

Supplemental Content

Table of contents

• Summary
• Genomic context
• Genomic regions, transcripts, and products
• Expression
• Bibliography
• Phenotypes
• Variation
• Pathways from PubChem
• Interactions
• General gene information Markers, Homology, Gene Ontology
• General protein information
• NCBI Reference Sequences (RefSeq)
• Related sequences
• Additional links

Genome Browsers

• Loading...

Related information

• Order cDNA clone Order cDNA clone
• 3D structures 3D structure of a gene
• BioAssay by Target (List) BioAssays related to the gene by protein target or RNAi target
• BioAssay by Target (Summary) Summarized PubChem Data on the gene, showing the active data by default
• BioAssay, by Gene target PubChem BioAssays done on the Gene target
• BioAssays, RNAi Target, Active BioAssays that contain the gene as the target of a RNAi reagent, which is identified as a hit in a RNAi screening and flagged as "active" in the corresponding BioAssay record
• BioAssays, RNAi Target, Tested BioAssays that contain the gene as the target of a RNAi reagent
• BioProjects BioProjects related to a gene
• CCDS Link to CCDS
• ClinVar Related medical variations
• Conserved Domains Related CDD
• dbVar Link from Gene to dbVar
• Full text in PMC PMC links
• Full text in PMC_nucleotide Full text in PubMedCentral identified from shared sequence links
• Functional Class Functional class of the sequence domain architecture
• Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side
• Genome Related Genome
• GEO Profiles Related GEO
• GTR Tests for this gene in the NIH Genetic Testing Registry
• HomoloGene Related HomoloGene
• Nucleotide Link to related Nucleotide entry
• OMIM Link to related OMIM entry
• Protein Link to related protein entry
• PubChem Compound PubChem Compounds
• PubChem Substance PubChem Substances
• PubMed Link to related PubMed entry
• PubMed (GeneRIF) Link to related PubMed article from GeneRIFs
• PubMed (OMIM) Gene links to PubMed derived from omim_pubmed_cited links
• PubMed(nucleotide/PMC) Citations in PubMed identified from shared sequence and PMC links.
• RefSeq Proteins Link to Protein RefSeqs
• RefSeq RNAs Link to Nucleotide RefSeq RNAs
• Related gene-specific medical variations Related medical variations
• SNP Related SNP records
• Taxonomy Link to related taxonomy entry
• Variation Viewer Related Variants

Links to other resources

• HGNC
• Ensembl
• AllianceGenome
• AceView
• UCSC
• MGC
• HuGE Navigator
• KEGG
• Reactome

General information

• About Gene
• FAQ
• FTP site
• Help
• My NCBI help
• NCBI Handbook
• Statistics

Related sites

• BLAST
• Genome
• BioProject
• Genome Data Viewer
• GEO
• OMIM
• Probe
• RefSeq

Feedback

• Contact Help Desk
• Submit Correction
• Submit GeneRIF

Subscription

• RefSeq

Recent activity

Clear Turn Off Turn On

• HRH1 histamine receptor H1 [Homo sapiens] HRH1 histamine receptor H1 [Homo sapiens]Gene ID:3269 Gene

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more... Follow NCBI Twitter Facebook LinkedIn GitHub NCBI Insights Blog

Connect with NLM

• Twitter
• Facebook
• Youtube

National Library of Medicine 8600 Rockville Pike Bethesda, MD 20894

Web Policies FOIA HHS Vulnerability Disclosure

Help Accessibility Careers

• NLM
• NIH
• HHS
• USA.gov