611045 - GLUCOSE-6-PHOSPHATASE, CATALYTIC, 3; G6PC3

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By searching databases for homologs of IGRP (G6PC2; 608058), Martin et al. (2002) identified G6PC3, which they called UGRP. The predicted 346-amino acid protein has a calculated molecular mass of 38.7 kD and shares 36% and 37% identity with G6PC1 (232200) and IGRP, respectively. G6PC3 has 9 transmembrane domains and conserved G6Pase catalytic residues, but unlike G6PC1 and IGRP, it lacks N-linked glycosylation sites and the C-terminal KKxx motif characteristic of ER-resident transmembrane proteins. RNA blot analysis revealed ubiquitous expression of a 1.5-kb G6PC3 transcript. Expression was highest in skeletal muscle, intermediate in heart, brain, placenta, kidney, colon, thymus, spleen, and pancreas, and low in liver, lung, small intestine, and peripheral blood leukocytes.

By database analysis and RT-PCR of brain mRNA, Guionie et al. (2003) cloned human G6PC3.

Using Northern blot analysis, Cheung et al. (2007) found that G6PC3 was expressed in human blood neutrophils. RT-PCR showed that mouse leukocytes, neutrophils, and bone marrow expressed G6pc3 at similar levels.

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