Activation Of NK Cells By Extracellular Heat Shock Protein 70 Through ...

Trang chủ » Sốc Nk » Activation Of NK Cells By Extracellular Heat Shock Protein 70 Through ...

Có thể bạn quan tâm

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content Dot gov

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation pubmed logo Search: Search Advanced Clipboard User Guide Save Email Send to
  • Clipboard
  • My Bibliography
  • Collections
  • Citation manager
Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

  • Create a new collection
  • Add to an existing collection
Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

  • My Bibliography
Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons
  • Yes
  • No
Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Free PMC article Full text links

Actions

CiteCollectionsAdd to Collections
  • Create a new collection
  • Add to an existing collection
Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

  • Title & authors
  • Abstract
  • Figures
  • References
  • Publication types
  • MeSH terms
  • Substances
  • LinkOut - more resources
Title & authors Abstract Figures References Publication types MeSH terms Substances LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

We have previously reported that heat shock protein 70 (HSP70) vaccination induced natural killer (NK) cell activity in patients with chronic myelogenous leukemia (CML). In this study, HSP70 of both autologous and allogeneic origin was found to stimulate IFN-gamma production from peripheral blood mononuclear cells of CML patients, as well as of normal subjects. Further investigations demonstrated that the activity of HSP70 was dependent on both NK cells and dendritic cells (DCs). HSP70 did not induce significant IFN-gamma production from either NK cells or DCs alone. Mechanistically, we found that HSP70-mediated DC-NK cell crosstalk required cell-cell contact, which could be inhibited completely by neutralizing antibody against NK activating receptor NKG2D. The significance of NKG2D was further corroborated by the finding that HSP70 induced the expression of an NKG2D ligand, the MHC class I chain-related protein A (MICA), on DCs; HSP70-augmented IFN-gamma release was abrogated by antibody against MICA. Thus extracellular HSP70, released during either stress or inflammatory cell death, may serve as a critical link between NK and DCs in mounting immune responses against infections, cancers and self-antigens.

PubMed Disclaimer

Figures

Figure 1

Figure 1

Figure 1

Figure 1
Figure 2

Figure 2

Figure 2

Figure 2
Figure 3

Figure 3

Figure 3

Figure 3
Figure 4

Figure 4

Figure 4

Figure 4
Figure 5

Figure 5

Figure 5

Figure 5
See this image and copyright information in PMC

References

    1. Steinman RM. Dendritic cells: from the fabric of immunology. Clin Invest Med. 2004;27:231–236. - PubMed
    1. Yokoyama WM, Kim S, French AR. The dynamic life of natural killer cells. Annu Rev Immunol. 2004;22:405–429. - PubMed
    1. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu Rev Immunol. 2000;18:767–811. - PubMed
    1. Guermonprez P, Valladeau J, Zitvogel L, Thery C, Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol. 2002;20:621–667. - PubMed
    1. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol. 2003;21:685–711. - PubMed
Show all 50 references

Publication types

  • Research Support, Non-U.S. Gov't Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

MeSH terms

  • Cancer Vaccines Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Cell Communication Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Dendritic Cells / immunology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Gene Expression Regulation, Leukemic Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • HSP70 Heat-Shock Proteins / blood Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • HSP70 Heat-Shock Proteins / immunology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • HSP70 Heat-Shock Proteins / pharmacology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Histocompatibility Antigens Class I / metabolism Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Humans Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Interferon-gamma / metabolism Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • K562 Cells Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Killer Cells, Natural / immunology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / immunology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Ligands Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Lymphocyte Activation / drug effects* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Lymphocyte Subsets / immunology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • NK Cell Lectin-Like Receptor Subfamily K / metabolism Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Signal Transduction / immunology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

Substances

  • Cancer Vaccines Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • HSP70 Heat-Shock Proteins Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Histocompatibility Antigens Class I Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • KLRK1 protein, human Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Ligands Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • MHC class I-related chain A Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • NK Cell Lectin-Like Receptor Subfamily K Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Interferon-gamma Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

LinkOut - more resources

  • Full Text Sources

    • Europe PubMed Central
    • PubMed Central

  • Medical

    • MedlinePlus Health Information

  • Research Materials

    • NCI CPTC Antibody Characterization Program
Full text links [x] Free PMC article [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To
  • Clipboard
  • Email
  • Save
  • My Bibliography
  • Collections
  • Citation Manager
[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

Từ khóa » Sốc Nk