Amino DT C6 Oligo Modifications From Gene Link

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picture of Amino deoxythymidine dT C6

Modification : Amino dT C6

Catalog Reference Number Category Modification Code 5 Prime 3 Prime Internal Molecular Weight (mw) Extinction Coeficient (ec) Technical Info (pdf) Absorbance MAX Emission MAX Absorbance EC 26-6438 Minor Bases [Am-dT-C6] Y Y Y 458.41 8.4 PS26-6438-02.pdf - - -

Catalog NoScalePrice
26-6438-0550 nmol$199.00
26-6438-02200 nmol$199.00
26-6438-011 umol$228.00
26-6438-032 umol$297.00
26-6438-065 umol$1,026.00
26-6438-1010 umol$1,485.00
26-6438-1515 umol$1,782.00
Discounts are available for Amino dT C6!
Modification* Discount Price Structure
1 site/order List price
2 sites/order 10% discount
3 sites/order 20% discount
4 sites/order 30% discount
5-9 sites/order 50% discount
10+ sites/order 60% discount
*Exceptions apply
Related Modifications
Amino dA C6 Amino C6 Amino Serinol
Amino C7- 3' NHS-Carboxy-dT Carboxy-dT
Amino dG C6 Amino C3-5' Amino C6 U
Amino dC C6 Amino dT 5' Amino C12-5'
Amino Spacer 7-C6 (3')

Amino dT C6 can be used to internally incorporate an active primary amino group into either a DNA oligonucleotide or a chimeric oligo. The presence of the primary amino group allows the user to label the oligo with a variety of different ligands for affinity, reporter or protein moieties (as NHS esters or isothiocyanates), depending on the application. Examples include biotin, digoxigenin, and fluorescent dyes or quenchers, magnetic beads and enzymes (for example, alkaline phosphatase). NHS ester-activated ligands react with primary amines to yield stable amide bonds. The reaction releases N-hydroxysuccinimide (NHS). NHS ester reaction scheme for chemical conjugation to a primary amine in an oligo is given below.

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The primary amine labelled oligos can also be conjugated to carboxyl functional groups usually for solid supports applications using EDC mediated reaction as shown in the figure below.

- Amino deoxythymidine dT C6

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