Anti-Hemoglobin ζ Antibody (C-1B3) | SCBT
Hemoglobin ζ Antibody (C-1B3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Hemoglobin zeta protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Hemoglobin zeta antibody (C-1B3) is available as the non-conjugated form. Hemoglobin, a crucial protein in the body, is responsible for transporting oxygen from the lungs to tissues and facilitating the return of carbon dioxide from tissues back to the lungs. Hemoglobin zeta protein plays a significant role during embryonic development, particularly in the yolk sac stage, where expression occurs before the switch to adult hemoglobin forms. This early expression is vital for ensuring that the developing embryo receives adequate oxygen supply during a critical period of growth. The protein′s structure, which consists of two alpha and two zeta chains, allows for the formation of a tetramer that can effectively bind oxygen. The unique properties of the zeta chain, including its interaction with heme groups, contribute to the overall functionality of hemoglobin in oxygen transport. Understanding the role of Hemoglobin zeta is essential for studying various hematological disorders and developmental biology, making Hemoglobin ζ monoclonal antibody (C-1B3) a valuable tool for researchers in these fields.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Hemoglobin ζ Antibody (C-1B3) References:
- Assembly of human hemoglobin (Hb) beta- and gamma-globin chains expressed in a cell-free system with alpha-globin chains to form Hb A and Hb F. | Adachi, K., et al. 2002. J Biol Chem. 277: 13415-20. PMID: 11827978
- Linkage of interactions in sickle hemoglobin fiber assembly: inhibitory effect emanating from mutations in the AB region of the alpha-chain is annulled by a mutation at its EF corner. | Sudha, R., et al. 2004. J Biol Chem. 279: 20018-27. PMID: 14982923
- Transfer of human alpha- to beta-hemoglobin via its chaperone protein: evidence for a new state. | Baudin-Creuza, V., et al. 2004. J Biol Chem. 279: 36530-3. PMID: 15220346
- Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin. | Feng, L., et al. 2004. Cell. 119: 629-40. PMID: 15550245
- Effect of zeta-globin substitution on the O2-transport properties of Hb S in vitro and in vivo. | He, Z. and Russell, JE. 2004. Biochem Biophys Res Commun. 325: 1376-82. PMID: 15555579
- Verrucous hemangioma expresses primitive markers. | Laing, EL., et al. 2013. J Cutan Pathol. 40: 391-6. PMID: 23379586
- 3,3',5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α. | Chen, H., et al. 2021. J Hematol Oncol. 14: 99. PMID: 34174920
- Quantification of human embryonic ζ-globin chains in Southeast Asian deletion (--SEA) carriers. | Ye, Y., et al. 2023. J Clin Pathol. 76: 784-789. PMID: 36008105
- Molecular basis of length polymorphism in the human zeta-globin gene complex. | Goodbourn, SE., et al. 1983. Proc Natl Acad Sci U S A. 80: 5022-6. PMID: 6308667
- Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin. | Liebhaber, SA., et al. 1981. Nature. 290: 26-9. PMID: 7010180
- The multiple functions of hemoglobin. | Giardina, B., et al. 1995. Crit Rev Biochem Mol Biol. 30: 165-96. PMID: 7555018
- Hb E and alpha-thalassemia; variability in the assembly of beta E chain containing tetramers. | Huisman, TH. 1997. Hemoglobin. 21: 227-36. PMID: 9140719
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