In your acronym, the B-NHEJ stands for "backup" NHEJ, and refers to alt-NHEJ. These pathways utilize different sets of proteins, and in general are much less ...
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1 thg 10, 2012 · The results document a rapid and fully reversible adaptation of B-NHEJ to growth activity and point to factors beyond EGFR in its regulation ...
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Furthermore, the activity of B-NHEJ is compromised when cells enter the plateau phase of growth. Together, these observations uncover a repair pathway with ...
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16 thg 1, 2014 · Non-homologous end-joining (NHEJ) is a prominent DSB repair pathway ... as A-EJ or alt-NHEJ (alternative end-joining), B-NHEJ (backup NHEJ), ... Abstract · Canonical NHEJ versus... · C-NHEJ Is a Conservative but... · Conclusion
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1 thg 10, 2012 · Serum deprivation in D-NHEJ-deficient cells causes a rapid reduction in B-NHEJ similar to that measured in normally growing cells that enter the ...
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homologous end joining (NHEJ). In addition to the DNA-PK dependent pathway of NHEJ (D-NHEJ), cells employ a back up pathway (B-NHEJ) using DNA ligase III ...
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component of B-NHEJ. Here, we use RNA interference (RNAi) to further investigate the activity requirements for DNA ligase III and IV in.
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29 thg 5, 2020 · PARP1 and the MRN proteins in the B-NHEJ route for the repair of DNA DSBs. INTRODUCTION. Double-strand break (DSB) is toxic DNA damage that, ...
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B-NHEJ kinetics in TSA-treated serum deprived M059K cells incubated for repair in the presence of 20 μM wortmannin. Other details are as shown in Figure 6 ...
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23 thg 4, 2014 · In addition to our results showing that B-NHEJ is involved in the repair of DNA damage in HRR deficient cells resulting in high frequency of CEs ...
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PURPOSE: The backup pathway of nonhomologous end joining (B-NHEJ) enables cells to process DNA double-strand breaks (DSBs) when the DNA-PK-dependent pathway ...
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19 thg 4, 2014 · B-NHEJ. Chromosome and chromatid translocations are manifestations of erroneous DSB ... between B-NHEJ and DNA end resection in translo-.
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From the homologyindependent pathways, both DNA-PK-dependent nonhomologous end joining (D-NHEJ) and backup nonhomologous end joining (B-NHEJ) have the ...
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16 thg 10, 2020 · We apply cytogenetics and high-throughput sequencing assays to measure end joining in a panel of mouse pro-B cell lines deficient for NHEJ ( ...
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Nonhomologous end-joining (NHEJ) inhibition at telomeres prevents fusions between two telomeres and ... (B) NHEJ inhibition by internal telomeric repeats.
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(b) NHEJ-based knock-in, which requires the linearization of donor template rather than the homology arms. (c) MMEJ-based knock-in requires short homology arms ...
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29µ B cell lymphoma and splenic B cells, PARP inhibitors lead to increased antibody class switching (122). It appears therefore that the context of the DSB ...
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