Binding Of Human Growth Hormone (GH) - PubMed

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Abstract

Human GH-variant (hGH-V) is a natural GH analog arising from the hGH-V gene. It is expressed in the placenta and secreted into the maternal circulation during the second half of pregnancy. To gain information about its bioactivity in man, we examined the interaction of hGH-V with the high affinity GH-binding protein/receptor (GH-BP) in human plasma. hGH-V was equipotent with pituitary hGH (hGH-N) as a ligand for the GH-BP. hGH-N/hGH-V chimeric proteins, where the sequences encoded by exon 3 (amino acid residues 32-71, thought to be exposed on the molecule's surface and involved in receptor binding) were exchanged, also bound with similarly high affinities. A corresponding hGH-N/rat PRL chimeric protein had 25-fold reduced affinity for the GH-BP. We conclude that hGH-V is a potent somatogen in man, and that some of the manifestations of late pregnancy, such as increased insulin-like growth factor-I levels and coarsening of features, are probably related to the high circulating levels of hGH-V. GH-BP measurements in pregnancy must take into account BP saturation by endogenous hGH-V.

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  • Placental growth hormones. Lacroix MC, Guibourdenche J, Frendo JL, Pidoux G, Evain-Brion D. Lacroix MC, et al. Endocrine. 2002 Oct;19(1):73-9. doi: 10.1385/ENDO:19:1:73. Endocrine. 2002. PMID: 12583604 Review.
  • Circulating growth hormone binding proteins. Baumann G, Shaw MA, Amburn K. Baumann G, et al. J Endocrinol Invest. 1994 Jan;17(1):67-81. doi: 10.1007/BF03344965. J Endocrinol Invest. 1994. PMID: 8006328 Review. No abstract available.

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