BioTherapeutics Lab

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Welcome to Cheng Lab

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The BioTherapeutics Laboratory is led by Dr. Ke Cheng. We are part of the Department of Biomedical Engineering at Columbia University, in the city of New York. Previously, BioTherapeutics Lab was part of the Department of Molecular and Biomedical Sciences at the North Carolina State University College of Veterinary Medicine as well as the Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill and North Carolina State University. Our studies include regenerative medicine approaches by using patient-derived stem cells, biomaterials, and targeted nanoparticles. For stem cell research, we are interested in isolating patient-specific and organ-specific adult stem cells and testing their regenerative potential in small/large animal models of diseases. We are also taking an integrated approach that combines cells, biomaterials, nanoparticles, and other bioengineering approaches such as magnetic targeting to enhance the efficiency of stem cell therapies.

  • The cover of our new paper in Nature Biomedical Engineering illustrates an inhalable virus-like-particle vaccine made of exosomes derived from lung cells and decorated with a recombinant SARS-CoV-2 receptor-binding domain.
  • Our research on acellular artificial cardiac patch was recently featured on the cover of Science Translational Medicine
  • Our research on platelet microparticles for cardiac repair was featured on the cover of Science Advances
  • Our research was featured on the cover of Advanced Functional Materials
  • Our research was featured on the cover of Advanced Therapeutics
  • Our research was featured on the cover of Theranostics
  • Our research was featured on the cover of Stem Cell Translational Medicine
  • Our research on cardiac stromal cell patch integrated with engineered biomimetic microvessels (BMVs) was recently featured on the cover of ACS Biomaterials Science & Engineering
  • Our work on a new antibody therapy redirecting stem cells from the lungs to repair heart injury was featured on the cover of Advanced Science

Latest news:

  • Dr. Ke Cheng receives the AAEV Founder’s Award, and inducted into the inaugural class of AAEV FellowNovember 25, 2025
  • Congratulations to Dr. Cheng for receiving the 2025 Clemson Award For Applied Research!April 23, 2025
  • Congratulations to Weihang for receiving the Alan L. Kaganov FellowshipDecember 4, 2024
  • Dr. Ke Cheng delivered the Archimedes Lecture and met with Carol KaganovDecember 4, 2024
  • Dr. Ke Cheng Recognized among 2024 Highly Cited Researchers from ClarivateDecember 2, 2024

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