C-BU99008 has previously been identified as a putative PET radioligand. Here, we present the first in vivo characterization of this PET radioligand in humans ...
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These data demonstrate that (11)C-BU99008 represents a specific and selective PET radioligand for imaging and quantifying the I2BS, in vivo, in the rhesus ...
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1 thg 5, 2014 · Work is under way to assess the utility of 11C-BU99008 as a PET ligand for in vivo imaging and quantification of I2BS in the human population, ...
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1 thg 10, 2018 · To meet the aims of this study and determine the regional density and distribution of I2BS in healthy human brain, scans using 11C-BU99008 were ...
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23 thg 4, 2021 · identified a new PET-tracer called 11C-BU99008, specifically and selectively targeting outer mitochondrial imidazoline2 binding sites (I2BS) ...
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15 thg 7, 2021 · Abstract. 11C-BU99008 is a novel positron emission tomography (PET) tracer that enables selective imaging of astrocyte reactivity in vivo. To ...
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It has been reported that PET probe with ultra-high SA can detect small change caused by endogenous or exogenous ligand. Recently, Kealey et al. developed [11C] ... Bị thiếu: c- 11
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A useful PET probe [11C]BU99008 with ultra-high specific radioactivity for small animal PET imaging of I2-imidazoline receptors in the hypothalamus☆ · Abstract ...
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(11)C-BU99008 was demonstrated to readily enter the brain, resulting in a heterogeneous distribution (globus pallidus > cortical regions > cerebellum) ...
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26 thg 7, 2021 · The researchers studied the uptake of carbon-11 (C-11) BU99008 in diseased brain regions of patients with late-life cognitive impairment ...
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30 thg 7, 2018 · We measured whole body distribution of 11C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site.
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First evaluation of PET-based human biodistribution and radiation dosimetry of. 11. C-BU99008, a tracer for imaging the imidazoline2 binding site.
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Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired ...
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1 thg 7, 2006 · One-way ANOVA was used to compare [11C]BU99008 uptake between groups. Results. We found a greater difference in the [11C]-BU99008 uptake in ...
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