C/EBP Regulates Hepatic Transcription Of 11beta - PubMed

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Elsevier Science Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Substances
• Associated data
• LinkOut - more resources

Title & authors Abstract Publication types MeSH terms Substances Associated data LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Glucocorticoid action within individual cells is potently modulated by 11beta-hydroxysteroid dehydrogenase (11beta-HSD), which, by interconverting active and inert glucocorticoids, determines steroid access to receptors. Type 1 11beta-HSD (11beta-HSD1) is highly expressed in liver where it regenerates glucocorticoids, thus amplifying their action and contributing to induction of glucocorticoid-responsive genes, most of which are also regulated by members of the C/EBP (CAAT/enhancer-binding protein) family of transcription factors. Here we demonstrate that C/EBPalpha is a potent activator of the 11beta-HSD1 gene in hepatoma cells and that mice deficient in C/EBPalpha have reduced hepatic 11beta-HSD1 expression. In contrast, C/EBPbeta is a relatively weak activator of 11beta-HSD1 transcription in hepatoma cells and attenuates C/EBPalpha induction, and mice that lack C/EBPbeta have increased hepatic 11beta-HSD1 mRNA. The 11beta-HSD1 promoter (between -812 and +76) contains 10 C/EBP binding sites, and mutation of the promoter proximal sites decreases the C/EBP inducibility of the promoter. One site encompasses the transcription start, and both C/EBPalpha and C/EBPbeta are present in complexes formed by liver nuclear proteins at this site. The regulation of 11beta-HSD1 expression, and hence intracellular glucocorticoid levels, by members of the C/EBP family provides a novel mechanism for cross-talk between the C/EBP family of transcription factors and the glucocorticoid signaling pathway.

PubMed Disclaimer

Publication types

• Research Support, Non-U.S. Gov't Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• 11-beta-Hydroxysteroid Dehydrogenases Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Base Sequence Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Binding Sites Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• CCAAT-Enhancer-Binding Proteins / genetics Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• CCAAT-Enhancer-Binding Proteins / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Cell Nucleus / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Cloning, Molecular Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• DNA Footprinting Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Gene Expression Regulation Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Glucocorticoids / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Hydroxysteroid Dehydrogenases / genetics* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Liver / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Mice Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Mice, Knockout Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Molecular Sequence Data Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Promoter Regions, Genetic* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Protein Binding Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Sequence Analysis, DNA Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Signal Transduction Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Subcellular Fractions / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Transcription, Genetic Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• CCAAT-Enhancer-Binding Proteins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Glucocorticoids Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Hydroxysteroid Dehydrogenases Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• 11-beta-Hydroxysteroid Dehydrogenases Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Associated data

• GENBANK/Y10420 Actions
  • Search in PubMed
  • Search in Nucleotide

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • GlyGen glycoinformatics resource

Full text links [x] Elsevier Science [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.