C(sp3)–H Hydroxylation Of Fluorenes, Oxindoles And Benzofuranones ...

C(sp3)–H hydroxylation of fluorenes, oxindoles and benzofuranones with a Mg(NO3)2–HP(O)Ph2 oxidation system†

Chen Hu,a Gang Hong, b Pradip D. Nahide, b Yuchen He,a Chen Zhou,a Marisa C. Kozlowski*b and Limin Wang *a Author affiliations

* Corresponding authors

a Key Laboratory for Advanced Materials, Institute of Fine Chemicals and School of Chemistry & Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China E-mail: [email protected]

b Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA E-mail: [email protected]

Abstract

A novel oxidation system in which magnesium nitrate [Mg(NO3)2] is used as an oxidant in the presence of diphenylphosphine oxide [HP(O)Ph2] permits the C(sp3)–H hydroxylation of fluorenes, oxindoles, and benzofuranones. This method features high efficiency, good functional group tolerance, and operational simplicity. Its synthetic utility is highlighted by further transformations to valuable organic materials.

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