C75 | Fatty Acid Synthase Inhibitor - MedChemExpress

• •Nucleic Acid Gel Electrophoresis
• •Vector Construction
• •Restriction Endonuclease
• •Materials
• •PCR & qPCR
• •RT-PCR
• •Sequencing

• •Protein Sample Preparation
• •Protein Purification
• •Protein Electrophoresis & WB
• •Labeling Kit
• •Multiple Fluorescent Staining

• •Cell Culture
• •Cell Analysis
• •3D Cell Culture
• •Cell Isolation

• Cytokines and Growth Factors
• Immune Checkpoint Proteins
• CAR-T Related Proteins
• CD Antigens
• Fc Receptors
• Receptor Proteins
• Enzymes & Regulators
• Complement System
• Ubiquitin Related Proteins
• Viral Proteins
• Biotinylated Proteins
• Fluorescent-labeled Recombinant Proteins
• GMP-grade Proteins
• Animal-free Recombinant Proteins
• Others
• View More

• Interleukin & Receptors
• Interferon & Receptors
• Chemokine & Receptors
• TNF Superfamily
• CSF & Receptors
• TGF-beta Superfamily
• PDGFs & PDGFRs
• VEGF & VEGFR
• EGF Superfamily
• FGF Family
• HGF & Receptors
• Neurotrophic Factors
• Ephrin/Eph Family
• Angiopoietins
• IGF family
• Peptide Hormone & Neuropeptides

• Inhibitory Checkpoint Molecules
• Stimulatory Immune Checkpoint Molecules
• Butyrophilins

• CD27 Ligand/CD70
• CD4
• CD19
• CD27 Ligand/CD70
• CD123
• CD138/Syndecan-1
• Epithelial Cell Adhesion Molecule (EpCAM)
• Folate Receptor 1
• GPC-3
• Guanylate Cyclase 2C
• ErbB2/HER2
• ErbB3/HER3
• c-Met/HGFR
• MSLN
• CA-125
• ROR1
• CEACAM-5
• CD314/NKG2D
• Prostate Specific Membrane Antigen
• CD319/SLAMF7
• TROP-2
• Siglec-6
• Folate Receptor alpha (FR-alpha)
• CD314/NKG2D
• Siglec-3/CD33
• CD27 Ligand/CD70
• CD319/SLAMF7
• ErbB2/HER2
• Siglec-3/CD33
• CD7
• MUC-1/CD227

• T Cell CD Proteins
• B Cell CD Proteins
• NK Cell CD Proteins
• Macrophage CD Proteins
• Monocyte CD Proteins
• Stem Cell CD Proteins
• Platelet CD Proteins
• Erythrocyte CD Proteins
• Dendritic Cell CD Proteins
• Epithelial cell CD Proteins
• Endothelial cell CD Proteins
• Signal Transduction-related CD Proteins
• Cell Adhesion-related CD Proteins

• Fc-gamma Receptor
• FcRn
• Fc-epsilon Receptor
• Fc alpha/mu Receptor
• Polymeric Immunoglobulin Receptor
• FcμR
• Fc Receptor-like Proteins
• Immunoglobulin Fc Region
• Fc alpha RI/CD89

• Receptor Tyrosine Kinases
• Receptor Serine/Threonine Kinases
• Receptor Tyrosine Phosphatase
• Receptor Guanylyl Cyclase Family
• Cell Adhesion Molecules (CAMs)
• G-Protein-Coupled Receptors (GPCRs)
• Nuclear Receptor Superfamily
• Pattern Recognition Receptors
• Notch family
• Siglec
• Leukocyte Immunoglobin-like Receptors
• Killer-Cell Immunoglobulin-like Receptors
• Cytokine Receptors

• Oxidoreductases (EC 1)
• Transferases (EC 2)
• Hydrolases (EC 3)
• Lyases (EC 4)
• Isomerases (EC 5)
• Ligases (EC 6)
• Translocases (EC 7)
• Matrix Metalloproteinases
• ADAMs/ADAMTSs
• Cathepsin
• Carboxypeptidase
• Angiotensin-converting Enzymes
• Caspase
• Carbonic Anhydrase
• Serine/Threonine Kinase Proteins
• Protein Tyrosine Kinases
• Phosphatase
• Topoisomerase
• Protease Inhibitors
• Protein Kinase Inhibitor Peptide (PKI)
• Cyclin-Dependent Kinase Inhibitor Proteins
• Cystatin Family

• Complement Component 1
• Complement Component 2
• Complement Component 3
• Complement Component 4
• Complement Component 5
• Complement Component 6
• Complement Component 7
• Complement Component 8
• Mannose-binding Protein
• MASP-1
• MASP-2
• Complement Regulatory Proteins
• Complement Receptor

• Ubiquitin/UBLs
• Ubiquitin Enzymes
• Deubiquitinase

• SARS-CoV-2 Proteins
• Zika Virus Proteins
• RSV Proteins
• Hepatitis C Virus Proteins
• Hepatitis B Virus Proteins
• HIV Proteins
• HPV Proteins
• Influenza Viruses Proteins
• Dengue Virus Proteins
• Ebola Virus Proteins
• Bacterial/Fungal Proteins

• Molecular Biology
• •Nucleic Acid Gel Electrophoresis
• •Vector Construction
• •Restriction Endonuclease
• •Materials
• •PCR & qPCR
• •RT-PCR
• •Sequencing
• Protein Biology
• •Protein Sample Preparation
• •Protein Purification
• •Protein Electrophoresis & WB
• •Labeling Kit
• •Multiple Fluorescent Staining
• Cell Biology
• •Cell Culture
• •Cell Analysis
• •3D Cell Culture
• •Cell Isolation
• View More

• Nucleic Acid Gel Stain
• Agarose
• Loading & Running Buffer
• DNA Marker

• Seamless Cloning
• Ligase
• Endonuclease

• Polymerase Chain Reaction (PCR)
• Real-Time PCR
• DNA Polymerase

• Reverse transcription PCR
• RNase Inhibitor

• Enzymes

• Cell Lysis
• Washing Buffer
• Protease Inhibitor Cocktail
• Phosphatase Inhibitor Cocktail
• Deacetylase Inhibitor Cocktail
• Kinase Inhibitor Cocktail
• Protein Assay

• Magnetic Stand
• Magnetic Beads
• Affinity Chromatography Column
• Agarose Beads
• Equilibration Buffer
• Magnetic Agarose Beads
• Binding/Washing Buffer

• Electrophoresis Buffer
• Protein Marker
• Transfer Buffer
• Blocking Buffer
• Binding/Washing Buffer
• Chemiluminescent Detection
• Loading Buffer
• Protein Staining Solution

• Cell Transfection
• Mycoplasma Clearance
• Sterile Antibiotic Solution
• Cell Freezing
• CEPT cocktail
• Basal Cell Culture Media
• Balanced Salt Solutions
• Cell Culture Supplements
• Dissociation Reagents

• Cell Proliferation and Cytotoxicity
• Reporter Gene Testing
• Phalloidin Dye Conjugates
• Cell Apoptosis and Necrosis
• AntiFade Mounting Medium
• Mitochondrial Isolation
• Exosome Isolation, Purification and Detection
• Organelle Research
• Metabolism Assay Kit

• Basement Membrane Matrix
• Tumor Organoid Culture Medium
• Normal Tissue Organoid Culture Medium

• Articles
• Product Guides
• Learning & Download
• Biomedical Dictionary
• Blogs
• Protocols

• Exhibition Events
• Promotion
• MCE Webinar

• Custom Synthesis Service
• Bulk and Custom Synthesis Service
• ADC-Related Custom Services
• PROTAC-Related Custom Services
• Custom Reference Standard Products
• Custom Peptide Synthesis
• Protein Expression Service
• Protein Crystal Structure Elucidation
• Oligonucleotide Synthesis
• Fluorescent labeling Service
• Custom Synthesis of Stable Isotope-Labeled Compounds
• One-stop CDMO Service
• One-stop Compound Screening Platform
• Virtual Screening
• Molecular dynamics simulation
• Cell-based Compound Screening
• Ion Channel Screening
• Kinase Screening Service
• Surface Plasmon Resonance (SPR) Assay Service
• GPCR Bioassay Screening Services
• Nuclear Receptor Screening Services
• Affinity Mass Spectrometry
• DEL Synthesis and Screening
• Molarity Calculator
• Dilution Calculator

• Careers

1. Metabolic Enzyme/Protease
2. Fatty Acid Synthase (FASN)
3. C75

Solubility

Molarity Calculator

In Vivo Dissolution Calculator

C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator.

For research use only. We do not sell to patients.

C75 Chemical Structure

CAS No. : 218137-86-1

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 29 publication(s) in Google Scholar

Other Forms of C75:

• trans-C75 In-stock
• (−)-C75 Get quote
• (+)-trans-C75 Get quote

C75 Related Antibodies

26 Publications Citing Use of MCE C75

• •Nature. 2023 Jun;618(7964):374-382. [Abstract]
• •Gastroenterology. 2024 Jan 24:S0016-5085(24)00064-7. [Abstract]
• •Cell Metab. 2021 Jan 5;33(1):51-64.e9. [Abstract]
• •J Hepatol. 2020 May;72(5):976-989. [Abstract]
• •Nat Commun. 2024 Sep 27;15(1):8273. [Abstract]
• •Bioact Mater. 2024 Mar, 33, 85-99.

• •Cell Rep Med. 2024 May 29:101592. [Abstract]
• •J Immunother Cancer. 2021 Aug;9(8):e003093. [Abstract]
• •Cell Mol Biol Lett. 2024 Aug 21;29(1):112. [Abstract]
• •Mol Metab. 2024 May 4:101953. [Abstract]
• •J Neuroinflammation. 2023 Nov 15;20(1):264. [Abstract]
• •Cell Rep. 2023 Jan 31.
• •Cell Rep. 2022 Nov 8;41(6):111591. [Abstract]
• •Cell Death Dis. 2021 Oct 12;12(10):934. [Abstract]
• •Cell Death Dis. 2020 Jan 13;11(1):25. [Abstract]
• •Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]
• •Biochim Biophys Acta Mol Basis Dis. 2022 Sep 20;166550. [Abstract]
• •Anal Chem. 2020 Mar 17;92(6):4419-4426. [Abstract]
• •Cancers (Basel). 2024 Apr 25;16(9):1651. [Abstract]
• •Lipids Health Dis. 2024 Feb 3;23(1):37. [Abstract]
• •Respir Res. 2023 Mar 15;24(1):81. [Abstract]
• •Food Chem Toxicol. 2022 Oct 5;113450. [Abstract]
• •Am J Cancer Res. 2020 Feb 1;10(2):595-609. [Abstract]
• •Vet Microbiol. 2023 Jan 24;278:109668. [Abstract]
• •J Cell Sci. 2022 Jul 1;jcs.259090. [Abstract]
• •SSRN. 2023 May 24.

C75 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

C75 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

C75 purchased from MedChemExpress. Usage Cited in: Am J Cancer Res. 2020 Feb 1;10(2):595-609. [Abstract]

Featured Recommendations

•Related Screening Libraries:

• Covalent Screening Library Plus
• Bioactive Compound Library Plus
• Metabolism/Protease Compound Library
• Anti-Cancer Compound Library
• Covalent Screening Library
• Anti-Breast Cancer Compound Library
• Anti-Cancer Metabolism Compound Library
• Anti-Obesity Compound Library
• Lipid Metabolism Compound Library
• Human Metabolite Library
• Anti-Prostate Cancer Compound Library
• Heterocyclic Compound Library
• Metabolic Enzyme Compound Library
• Bioactive Compound Library Max
• Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

•Related Small Molecules:

•Related Proteins:

• Biological Activity

• Protocol

• Purity & Documentation

• References

• Customer Review

• [1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.

  [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.

  [3]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

  [4]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

  [5]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• Rating
• Lot Number *
• Submit an Image No file chosen (Maximum size is: 1024 Kb)
• PubMed ID
• If you have published this work, please enter the PubMed ID.
• Show My Name
• Your name will appear on the site.
• Email
• Remarks

C75 Related Classifications

• Cancer
• Cancer Targeted Therapy Cancer Metabolism and Metastasis

• Metabolic Enzyme/Protease
• Fatty Acid Synthase (FASN)

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C75218137-86-1C 75C-75Fatty Acid Synthase (FASN)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name	Salutation	Dr. Prof. Mr. Ms. Mrs. Miss.
Applicant Name *	Email Address *
Phone Number *	Organization Name *
Department *	Requested quantity *	mg g kg t ml l
Country or Region *	United StatesCanadaUnited KingdomAustraliaChinaGermanyFranceJapanKorea SouthSwitzerland------------------------------AlbaniaAlgeriaArgentinaArmeniaAustraliaAustriaAzerbaijanBahrainBangladeshBarbadosBelarusBelgiumBoliviaBosnia HerzegovinaBrazilBulgariaCameroonCanadaChileChinaColombiaCroatiaCyprusCzech RepublicDenmarkEcuadorEgyptEstoniaFijiFinlandFranceGeorgiaGermanyGibraltarGreeceHong Kong, ChinaHungaryIcelandIndiaIndonesiaIranIraqIrelandIsraelItalyJapanJordanKazakhstanKenyaKorea SouthKuwaitLatviaLebanonLibyaLithuaniaLuxembourgMacedoniaMalaysiaMaltaMexicoMoldovaMonacoMongoliaMontenegroMoroccoNepalNetherlandsNew ZealandNigeriaNorwayOmanPakistanParaguayPeruPhilippinesPolandPortugalPuerto RicoQatarRepublic of BeninRomaniaRussiaSaudi ArabiaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSpainSri LankaSurinameSwedenSwitzerlandSyriaTaiwan, ChinaThailandTunisiaTurkeyUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVenezuelaVietnamZambiaZimbabweOther CountriesMacao, China
Please select a local distributor ナミキ商事株式会社 コスモ・バイオ株式会社
Remarks

Bulk Inquiry

Inquiry Information

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

• [email protected]
• 609-228-6898
• Find Your Local Distributor

Thanks, your subscription has been confirmed. You will hear from us soon.

Submission failed, please try again later.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.