C75 | Fatty Acid Synthase Inhibitor - MedChemExpress

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1. Metabolic Enzyme/Protease
2. Fatty Acid Synthase (FASN)
3. C75

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C75 is a synthetic fatty-acid synthase (FASN) inhibitor; inhibits prostate cancer cells PC3 with an IC50 of 35 μM. C75 is a potent CPT1A activator.

For research use only. We do not sell to patients.

CAS No. : 218137-86-1

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 42 publication(s) in Google Scholar

Other Forms of C75:

• trans-C75 In-stock
• (−)-C75 Get quote
• (+)-trans-C75 Get quote
• C75 (Standard) Get quote

C75 Related Antibodies

39 Publications Citing Use of MCE C75

• •Nat Genet. 2025 Mar;57(3):680-693.
• •Gastroenterology. 2024 Jan 24:S0016-5085(24)00064-7. [Abstract]
• •Bioact Mater. 2023 Nov 9:33:85-99.
• •Nature. 2023 Jun;618(7964):374-382. [Abstract]
• •Cell Metab. 2021 Jan 5;33(1):51-64.e9. [Abstract]
• •J Hepatol. 2020 May;72(5):976-989. [Abstract]

• •Nat Commun. 2024 Sep 27;15(1):8273. [Abstract]
• •Cell Mol Biol Lett. 2024 Aug 21;29(1):112. [Abstract]
• •Cell Rep Med. 2024 May 29:101592. [Abstract]
• •J Neuroinflammation. 2023 Nov 15;20(1):264. [Abstract]
• •J Immunother Cancer. 2021 Aug;9(8):e003093. [Abstract]
• •Cell Death Dis. 2025 Oct 7;16(1):715. [Abstract]
• •Regen Biomater. 2025 Jun 16:12:rbaf056. [Abstract]
• •Cell Death Dis. 2021 Oct 12;12(10):934. [Abstract]
• •Cell Death Dis. 2020 Jan 13;11(1):25. [Abstract]
• •Hepatol Int. 2025 Nov 12. [Abstract]
• •Mol Metab. 2024 Jun:84:101953. [Abstract]
• •Cell Rep. 2023 Jan 31;42(1):112027.
• •Cell Rep. 2022 Nov 8;41(6):111591. [Abstract]
• •Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]
• •Anal Chem. 2020 Mar 17;92(6):4419-4426. [Abstract]
• •J Ethnopharmacol. 2026 Feb 28:357:120890. [Abstract]
• •PLoS Pathog. 2025 May 6;21(5):e1013068. [Abstract]
• •Mol Neurobiol. 2025 Apr 8. [Abstract]
• •Pharmaceuticals (Basel). 2025 Jan 31;18(2):194.
• •Cancers (Basel). 2024 Apr 25;16(9):1651. [Abstract]
• •Lipids Health Dis. 2024 Feb 3;23(1):37. [Abstract]
• •Respir Res. 2023 Mar 15;24(1):81. [Abstract]
• •Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166550. [Abstract]
• •Eur J Immunol. 2025 Dec;55(12):e70087. [Abstract]
• •Eur J Immunol. 2025 Oct;55(10):e70068. [Abstract]
• •Anticancer Drugs. 2025 Jul 1;36(6):459-467. [Abstract]
• •Vet Microbiol. 2023 Mar:278:109668. [Abstract]
• •Food Chem Toxicol. 2022 Nov:169:113450. [Abstract]
• •J Cell Sci. 2022 Aug 1;135(15):jcs259090. [Abstract]
• •Am J Cancer Res. 2020 Feb 1;10(2):595-609. [Abstract]
• •SSRN. 2025 Dec 23.
• •bioRxiv. 2025 February 08.
• •SSRN. 2023 May 24.

C75 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

C75 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

C75 purchased from MedChemExpress. Usage Cited in: Am J Cancer Res. 2020 Feb 1;10(2):595-609. [Abstract]

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• References

• Customer Review

• [1]. Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.

  [2]. Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+)-C75 is a strong anorectic drug; (-)-C75 has antitumor activity. Chirality. 2013 May;25(5):281-7.

  [3]. Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5628-33.

  [4]. Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9498-502.

  [5]. Yan Xue, et al. Inhibition of Carnitine Palmitoyltransferase 1A Aggravates Fatty Liver Graft Injury via Promoting Mitochondrial Permeability Transition. Transplantation. 2021 Mar 1;105(3):550-560.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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C75 Related Classifications

• Disease Areas
• Cancer Inflammation or Immune System Disease Metabolic or Endocrine Disease Urogenital Disease Digestive System Disease
• Lipid Metabolism Breast Cancer Prostate Cancer Urogenital Cancer Digestive System Inflammation
• Obesity

• Cancer
• Cancer Targeted Therapy Cancer Metabolism and Metastasis

• Metabolic Enzyme/Protease
• Fatty Acid Synthase (FASN)

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C75218137-86-1C 75C-75Fatty Acid Synthase (FASN)Inhibitorinhibitorinhibit

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• 1/16
• 1/16

  C75 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

  Cell Counting Kit-8 (CCK8) assay. NUPR1 overexpression-induced proliferation of MHCC-97H and SK-Hep1 cells can be reversed by C75 (50 μM; 48 h).
• 1/16

  C75 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2022 Oct 28;8(1):431. [Abstract]

  Transwell migration assay. C75 reduces the migration ability of NUPR1-overexpressing SK-Hep1 cells.
• 1/16

  C75 purchased from MedChemExpress. Usage Cited in: Am J Cancer Res. 2020 Feb 1;10(2):595-609. [Abstract]

  Of the transcription of spliced X-box-binding protein 1 (sXBP1) and phosphorylated translational initiation factor 2 in eukaryotes (eIF2α) are higher in ANGTPL4-/- macrophages but are restored to normal levels following C75 treatment.

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