31 Jan 2020 · This phase I/Ib trial studies the side effects and best dose of CB-839 HCl when given together with sapanisertib in treating patients with ...
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10 Jan 2019 · This phase I trial studies the best dose of CB-839 HCl when given together with carfilzomib and dexamethasone in treating patients with ...
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This phase 1 study will determine the recommended expansion dose and preliminary efficacy of MLN0128 and CB-839 in advanced non-small-cell lung cancer with ...
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16 Oct 2020 · CB-839 HCl (telaglenastat) is a first in class oral glutaminase inhibitor that blocks tumor glutamine consumption. Glutaminase inhibitors have ...
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CB-839 HCl (telaglenastat) is a first-in-class oral glutaminase inhibitor that blocks tumor glutamine consumption. Glutaminase inhibitors have synergistic ...
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13 Nov 2019 · Trial in Progress: Phase I Dose-Escalation and Dose-Expansion Trial of a Novel Glutaminase Inhibitor (CB-839 HCl) in Combination with ...
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5 Oct 2020 · CB-839 HCl (Telaglenastat) in Patients With. Advanced NSCLC (NCI 10327): Rationale and. Study Design. Jonathan W. Riess,. 1. Paul Frankel,.
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Winter. A Phase I/II Study of AZD9291 (Osimertinib) and CB-839 Hydrochloride HCl in Patients With EGFR-Mutant Non-Small Cell Lung Cancer.
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... Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study. ... how well glutaminase inhibitor telaglenastat hydrochloride (CB-839 HCl) works in ...
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Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC.
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A Phase Ib Study of AZD9291 (Osimertinib) and CB-839 HCl in Patients with EGFR Mutant Non-Small Cell Lung Cancer – ETCTN 10216. UVA Tracking #. HSR200081.
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CB-839 HCl and carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as ...
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20 May 2015 · 2512 Background: Glutamine is required for the growth and survival of multiple tumor types. CB-839 is a highly selective, reversible, ...
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This phase I/Ib trial studies the side effects and best dose of CB-839 HCl when given together with sapanisertib in treating patients with non-small cell ...
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