Center For Pharmacogenomics And Precision Medicine - UF Health

1. Research
2. Center for Pharmacogenomics and Precision Medicine

Mission

Our mission is to facilitate the clinical implementation of precision medicine by improving patient outcomes through the optimization of efficacy and limiting toxicity of drug therapy. This is accomplished through research, teaching and service focused on genetically-guided therapeutic decision-making, drug discovery and drug development.

Goals

• Enhance the quality of precision medicine through pharmacogenomics research
  • Bring together faculty working in the precision medicine field and increase multidisciplinary collaboration among faculty
  • Provide genotyping, gene expression, DNA methylation, and analytical services to the UF community and beyond
• Provide an environment for training clinical and translational scientists in pharmacogenomics
• Educate the UF Health community on pharmacogenomics

Services

Pharmacogenomic laboratory and analytical services are provided for UF and non-UF investigators through the CPPM Core Laboratory. Services are provided either as a price per sample or price per project depending on the service type and specific needs of the researcher. Researchers interested in multiple services will be provided with an estimate of the charges for the entire project. We strive to accommodate the needs of each researcher; if you do not see a service listed on our menu, please inquire.

GENOTYPING

Services and Pricing

Review our services, state-of-the-art technology, and pricing.

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Leadership

Co Directors

Department: Pharmacotherapy & Translational Research

Larisa H Cavallari Pharm.D., BCPS, FCCP

Chair, Professor and Debbie DeSantis Excellence Professorship Phone: (352) 273-8245 Email: [email protected] Department: Pharmacotherapy & Translational Research

Julio D Duarte Pharm.D., Ph.D., FAHA

Associate Professor Phone: (352) 273-8132 Email: [email protected]

Affiliated Faculty | Research Interests

CHIEF OF THE DIVISION OF CARDIOLOGY AND MEDICAL DIRECTOR OF THE UF HEALTH CARDIOVASCULAR CENTER

Dominick Angiolillo, M.D., Ph.D.

* Effectiveness of cardiovascular drugs

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Professor and the Debbie DeSantis Term Professor in the UF College of Pharmacy

Larisa Cavallari, Pharm.D.

* Effectiveness of cardiovascular drugs* Dose requirements of warfarin* Opioid effectiveness and toxicity* Drug metabolism enzyme activity and expression* Outcomes with clinical implementation of genotype-guided therapy

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Clinical Associate Professor

Emily Cicali, Pharm.D.

* Drug metabolism enzyme activity and expression* Outcomes with clinical implementation of genotype-guided therapy

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Research Assistant Professor

Joseph Collins, Ph.D.

* Epigenetic and genetic variation contributing to differences in pharmacogene expression* Computational approaches to utilize public datasets for variant discovery and validation

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Clinical Professor

David DeRemer, Pharm.D.

* Cancer treatment outcomes* Cardiotoxic response to cancer treatments (Cardio-Oncology)

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Associate Professor

Julio Duarte, Pharm.D., Ph.D.

* Effectiveness of cardiovascular drugs* Genomics to identify novel drug targets for cardiopulmonary diseases* Outcomes with clinical implementation of genotype-guided therapy

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Assistant Professor

Mohammed Gbadamosi, Ph.D.

* Personalized medicine* Immuno-oncology* Cancer disparities* Metastatic cancer* Big data analytics

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Associate Professor

Yan Gong, Ph.D.

* Effectiveness of cardiovascular drugs* Cardiotoxic response to cancer treatments (Cardio-Oncology)* Adverse drug response to antiresorptive drugs

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PRofessor

Awewura Kwara, M.D., M.B., ChB, M.P.H., TM

* Response to treatment for HIV, TB, HBV and other infectious diseases

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Associate Dean For Research And Graduate Education; Professor And The Frank A. Duckworth Eminent Scholar Chair

Jatinder Lamba, Ph.D., M.Sc.

* Cancer treatment outcomes* Toxicity to anti-leukemic agents* CRISPR/cas9 mediated genetic perturbation screening in cancer* Development of genomics guided immunotherapy for treatment of leukemia* Systems biology approaches using multi-dimensional data to establish prognostic markers in cancer

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Professor

John Markowitz, Pharm.D.

* Drug metabolism enzyme activity and expression* Drug transporter activity

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Assistant Professor

Caitrin McDonough, Ph.D., M.S.

* Effectiveness of cardiovascular drugs* Predisposition to adverse cardiovascular and cerebrovascular outcomes and high risk disease* Development of multi-dimensional data models for cardiovascular disease identification and prediction* Development of multi-dimensional data models for Alzheimer’s Disease and Related Dementias

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Clinical Assistant PRofessor

Khoa Nguyen, Pharm.D.

* Effectiveness of cardiovascular drugs* Opioid effectiveness and toxicity* Outcomes with clinical implementation of genotype-guided therapy

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Clinical Assistant Professor

Madeline Norris, Pharm.D.

* Outcomes with clinical implementation of genotype-guided therapy* DPYD-guided fluoropyrimidine use* Effective methods for patient and provider education

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Clinical Assistant Professor

Nathan Seligson, Pharm.D.

* Cancer treatment options* Systems biology approaches using multi-dimensional data to establish prognostic markers in cancer

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Research Assistant Professor

Marwa Tantawy, Ph.D.

* Cardiotoxic response in cancer treatment (Cardio-oncology)* Pharmacogenomics and personalized medicine* iPSC differentiation for mechanistic insights into cardiovascular complications

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Associate Professor

Katie Vogel Anderson, Pharm.D., Ph.D., BCACP, FCCP

* Student pharmacist success* Implementation and evaluation of patient and clinician education initiatives* Effective use of AI in Pharm.D. education

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ASSOCIATE PROFESSOR

Danxin Wang, M.D. Ph.D.

* Drug metabolism enzyme activity and expression

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