Ch27 PKa And PI Values - Chemistry - University Of Calgary

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Table of pKa and pI values

  • The pKa values and the isoelectronic point, pI, are given below for the 20 α-amino acids.
  • pKa1= α-carboxyl group, pKa2 = α-ammonium ion, and pKa3 = side chain group.
Amino acid pKa1 pKa2 pKa3 pI
Glycine 2.34 9.60 --- 5.97
Alanine 2.34 9.69 --- 6.00
Valine 2.32 9.62 --- 5.96
Leucine 2.36 9.60 --- 5.98
Isoleucine 2.36 9.60 --- 6.02
Methionine 2.28 9.21 --- 5.74
Proline 1.99 10.60 --- 6.30
Phenylalanine 1.83 9.13 --- 5.48
Tryptophan 2.83 9.39 --- 5.89
Asparagine 2.02 8.80 --- 5.41
Glutamine 2.17 9.13 --- 5.65
Serine 2.21 9.15 --- 5.68
Threonine 2.09 9.10 --- 5.60
Tyrosine 2.20 9.11 --- 5.66
Cysteine 1.96 8.18 --- 5.07
Aspartic acid 1.88 9.60 3.65 2.77
Glutamic acid 2.19 9.67 4.25 3.22
Lysine 2.18 8.95 10.53 9.74
Arginine 2.17 9.04 12.48 10.76
Histidine 1.82 9.17 6.00 7.59
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organic chemistry © Dr. Ian Hunt, Department of Chemistry University of Calgary

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