Ch27 PKa And PI Values - Chemistry - University Of Calgary
Chapter 27: Amino Acids, Peptides and Proteins |
Table of pKa and pI values
- The pKa values and the isoelectronic point, pI, are given below for the 20 α-amino acids.
- pKa1= α-carboxyl group, pKa2 = α-ammonium ion, and pKa3 = side chain group.
Amino acid | pKa1 | pKa2 | pKa3 | pI |
Glycine | 2.34 | 9.60 | --- | 5.97 |
Alanine | 2.34 | 9.69 | --- | 6.00 |
Valine | 2.32 | 9.62 | --- | 5.96 |
Leucine | 2.36 | 9.60 | --- | 5.98 |
Isoleucine | 2.36 | 9.60 | --- | 6.02 |
Methionine | 2.28 | 9.21 | --- | 5.74 |
Proline | 1.99 | 10.60 | --- | 6.30 |
Phenylalanine | 1.83 | 9.13 | --- | 5.48 |
Tryptophan | 2.83 | 9.39 | --- | 5.89 |
Asparagine | 2.02 | 8.80 | --- | 5.41 |
Glutamine | 2.17 | 9.13 | --- | 5.65 |
Serine | 2.21 | 9.15 | --- | 5.68 |
Threonine | 2.09 | 9.10 | --- | 5.60 |
Tyrosine | 2.20 | 9.11 | --- | 5.66 |
Cysteine | 1.96 | 8.18 | --- | 5.07 |
Aspartic acid | 1.88 | 9.60 | 3.65 | 2.77 |
Glutamic acid | 2.19 | 9.67 | 4.25 | 3.22 |
Lysine | 2.18 | 8.95 | 10.53 | 9.74 |
Arginine | 2.17 | 9.04 | 12.48 | 10.76 |
Histidine | 1.82 | 9.17 | 6.00 | 7.59 |
© Dr. Ian Hunt, Department of Chemistry |
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