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Conferences > ECBO > 2015 > PSIII > 953911

• Opto-Acoustic Methods and Applications in Biophotonics II
• SPIE Proceedings (Optica Publishing Group, 2015),
• paper 953911
• •https://doi.org/10.1364/ECBO.2015.953911

Characterisation of a PVCP based tissue-mimicking phantom for Quantitative Photoacoustic Imaging

Martina Fonseca, Bajram Zeqiri, Paul Beard, and Ben Cox

Author Information

Author Affiliations

Martina Fonseca,*,1 Bajram Zeqiri,2 Paul Beard,1 and Ben Cox1

1Department of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, UK

2National Physical Laboratory, Hampton Road, Teddington, Middlesex, TW11 0LW, UK

*Corresponding author: [email protected]

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• M Fonseca
• B Zeqiri
• P Beard
• B Cox

European Conference on Biomedical Optics 2015

• Munich Germany
• 21–25 June 2015
• In proceedings
• Opto-Acoustic Methods and Applications in Biophotonics II
• ISBN: 9781628417043

From the session POSTER SESSION (PSIII)

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• Get Citation Copy Citation Text M. Fonseca, B. Zeqiri, P. Beard, and B. Cox, "Characterisation of a PVCP based tissue-mimicking phantom for Quantitative Photoacoustic Imaging," in Opto-Acoustic Methods and Applications in Biophotonics II, V. Ntziachristos and R. Zemp, eds., Vol. 9539 of SPIE Proceedings (Optica Publishing Group, 2015), paper 953911. Export Citation
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  Optics & Photonics Topics ? The topics in this list come from the Optics and Photonics Topics applied to this article.
  • Clinical applications
  • Image resolution
  • Optical coherence tomography
  • Optical properties
  • Photoacoustic imaging
  • Tissue imaging

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Abstract

Photoacoustic imaging can provide high resolution images of tissue structure, pathology and function. As these images can be obtained at multiple wavelengths, quantitatively accurate, spatially resolved, estimates for chromophore concentration, for example, may be obtainable. Such a capability would find a wide range of clinical and pre-clinical applications. However, despite a growing body of theoretical papers on how this might be achieved, there is a noticeable lack of studies providing validated evidence that it can be achieved experimentally, either in vitro or in vivo. Well-defined, versatile and stable phantom materials are essential to assess the accuracy, robustness and applicability of multispectral Quantitative Photoacoustic Imaging (qPAI) algorithms in experimental scenarios. This study assesses the potential of polyvinyl chloride plastisol (PVCP) as a phantom material for qPAI, building on previous work that focussed on using PVCP for quality control. Parameters that might be controlled or tuned to assess the performance of qPAI algorithms were studied: broadband acoustic properties, multiwavelength optical properties with added absorbers and scatterers, and photoacoustic efficiency.

The optical and acoustic properties of PVCP can be tuned to be broadly representative of soft tissue. The Grüneisen parameter is larger than expected in tissue, which is an advantage as it increases the signal-to-noise ratio of the photoacoustic measurements. Interestingly, when the absorption was altered by adding absorbers, the absorption spectra measured using high peak power nanosecond-pulsed sources (typical in photoacoustics) were repeatably different from the ones measured using the low power source in the spectrophotometer, indicative of photochemical reactions taking place.

© 2015 SPIE

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• European Conference on Biomedical Optics 2015
• Munich Germany
• 21–25 June 2015
• ISBN: 9781628417043
• From the session POSTER SESSION (PSIII)

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