Comparison Between HG And MHG Enrichment - Figshare

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Comparison between HG and mHG Enrichment
  • https://doi.org/10.1371/journal.pcbi.0030039.g005Open external identifier URLCopy identifier URL to clipboardIdentifier Info
CiteDownload (0 kB)ShareEmbed figure posted on 2007-03-23, 00:41 authored by Eran Eden, Doron Lipson, Sivan Yogev, Zohar Yakhini<p>The mHG and HG methods were applied to ChIP–chip data of six TFs. The sequences were ranked according to the ChIP–chip binding signal, and the enrichment of the correct binding motif was recorded using mHG and HG with fixed target sets containing the top 10, 100, and 1,000 sequences as well as all sequences with ChIP–chip signal <10<sup>−3</sup>. All scores were corrected for multiple motif testing. The mHG score is also corrected for the multiple cutoff testing. The 10<sup>−3</sup> and mHG cutoffs for each experiment are shown. It can be seen that the two cutoffs are significantly different and that for all the tested TFs mHG produces better results than HG in terms of enrichment of the true motif.</p>

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